Abstract: The present invention relates to a preparation method of 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-formamide capable of enabling 4-chlorine-N-methylpyridine-2-formamide to react with 4-amino-3-fluorophenol in the presence of an inorganic base. The present invention employs the inorganic base to replace potassium t-butoxide in the prior art, thus effectively solving the problem of a potential safety hazard of the potassium t-butoxide in industrial production. In addition, after the reaction is completed, the present invention employs a crystallization method for separation to obtain a reaction product; thus compared with the methods of extraction, concentration and column isolation and purification employed in the prior art, the present invention has a simpler operation and a lower cost, results in less environment pollution and a higher yield, and is very suitable for industrial production.

Abstract: There is provided a core-shell particle comprising a polymer conjugate encapsulating an active agent, wherein the polymer conjugate comprises a biocompatible polymer and a polyacidic polymer. There is also provided a process for forming the core-shell particle, a delivery vehicle comprising the core-shell particle and a method for delivering an active agent to a desired site.

Abstract: Techniques are provided for generating and deploying a computer model with few inputs from a user. Techniques are also provided for creating a data mart that multiple computer models may leverage in order to decrease the time required to generate subsequent computer models.

Abstract: Techniques are provided for generating and deploying a computer model with relatively few inputs from a user. Techniques are also provided for creating a data mart that multiple computer models may leverage in order to decrease the time required to generate subsequent computer models.

Abstract: The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

Abstract: An abrasive article includes a body having abrasive particles contained within a bond material. The abrasive particles can include a majority content of silicon nitride and a minority content of sintering material including at least two rare-earth oxide materials. In an embodiment, the rare-earth oxide materials can include Nd2O3 and Y2O3. In a particular embodiment, the abrasive particles comprise a content (wt %) of Nd2O3 that is greater than a content of Y2O3 (wt %).

Abstract: A system for measuring nuclear magnetic resonance spin-lattice relaxation time T1 and spin-spin relaxation time T2 of a sample includes a source of a substantially uniform magnetic field B0 for immersing at least a portion of the sample; a nuclear magnetic resonance excitation and detection system constructed and arranged to excite at least a portion of the sample with a plurality of nuclear magnetic resonance pulse sequences, each applied with a repetition time that is preselected to be sensitive to a T1 value of at least a portion of the sample, and to detect nuclear magnetic resonance emissions from the sample in response to excitations to provide a plurality of detection signals; and a signal processing system configured to communicate with the nuclear magnetic resonance excitation and detection system to receive the plurality of detection signals.

Abstract: A method of identifying and communicating career path options for presentation to a member of a social networking system are disclosed. A selection of a job title from a member of a social networking system is received. Additional members of the social networking system having the job title are identified. A career path for the member is identified based on an analysis of a profile corresponding to the member in comparison to profiles corresponding to the additional members. Information pertaining to the career path may be communicated for presentation to the member in a user interface.

Abstract: Methods of identifying and communicating information pertaining to career path gaps between members of a social network system are disclosed. A career path corresponding to a plurality of members of a social network system is identified. Levels of professional qualifications of each of the plurality of members are identified. The identifying includes analyzing known data items pertaining to the levels of the professional qualifications and analyzing additional data items inferred from the known data items pertaining to the levels of professional qualifications for each of the plurality of members. A career path gap between a member of the plurality of members and an additional member of the plurality of members is identified. The career path gap includes a difference in the levels of professional qualifications between the member and the additional member. Information pertaining to the career path gap is communicated for presentation to the member in a user interface.

Abstract: A system, method, and apparatus are provided for depicting attributes of a user's or member's connections within a professional or social network, in a manner that enables insight into the nature of the connections. When insight into a first member's connections is to be depicted, one or more attributes of first-degree connections (i.e., direct connections) and/or other connections are retrieved (e.g., employer or associated organization, function or role, seniority, skill(s)), over all time or some threshold period of time into the past. The values for the attributes are aggregated over the examined connections, and some or all values are displayed with one or more visual characteristics (e.g., size, color) that indicate a frequency or commonness of the values among the connections. The system or apparatus may include a user interface through which the depiction is presented in place of or in addition to a display of the connections.

Abstract: Embodiments of the present application relate to a method of controlling float-out messages, a system for controlling float-out messages, an instant messaging client for controlling float-out messages, and a computer program product for controlling float-out messages. A method of controlling float-out messages is provided.

Abstract: This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.

Abstract: Embodiments of the present application relate to a method of controlling float-out messages, a system for controlling float-out messages, an instant messaging client for controlling float-out messages, and a computer program product for controlling float-out messages. A method of controlling float-out messages is provided.

Abstract: An abrasive article includes a bonded abrasive body having abrasive particles contained within a bond material. The abrasive particles include silicon carbide and are essentially free of carbon-based and boron-based sintering aid materials. In an embodiment, the bond material can include a phenolic resin. In another embodiment, the bonded abrasive body can include an oxide phase disposed interstitially between the silicon carbide abrasive particles. In an additional embodiment, the abrasive particles can consist essentially of silicon carbide and aluminum oxide in a ratio of silicon carbide to alumina of at least about 8:1.

Abstract: Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range.

Abstract: This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.

Abstract: A method, system and article of manufacture for determining a global hierarchy of an entity by computing subjective coherence strength between nodes of first members of a social network service, computing objective entanglement strength between nodes of second members of the social network service, using subjective coherence strength and objective entanglement strength, compute the pairwise latent relationship probabilities between different ones of the nodes of the social network service, and using the pairwise relationship probabilities, compute the global hierarchy relationship.

Abstract: A method, system and article of manufacture for determining a global hierarchy of an entity by computing subjective coherence strength between nodes of first members of a social network service, computing objective entanglement strength between nodes of second members of the social network service, using subjective coherence strength and objective entanglement strength, compute the pairwise latent relationship probabilities between different ones of the nodes of the social network service, and using the pairwise relationship probabilities, compute the global hierarchy relationship.

Abstract: An abrasive article includes a body having abrasive particles contained within a bond material. The abrasive particles can include a majority content of silicon nitride and a minority content of sintering material including at least two rare-earth oxide materials. In an embodiment, the rare-earth oxide materials can include Nd2O3 and Y2O3. In a particular embodiment, the abrasive particles comprise a content (wt %) of Nd2O3 that is greater than a content of Y2O3 (wt %).

Abstract: Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range.