Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yield-related polynucleotides and polypeptides in plants
    Publication number: 20030226173
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 9, 2002
    Publication date: December 4, 2003
    Inventors: Oliver Ratcliffe, Jose Luis Riechmann, Luc J. Adam, Arnold N. Dubell, Jacqueline E. Heard, Marsha L. Pilgrim, Cai-Zhong Jiang, T. Lynne Reuber, Robert A. Creelman, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Stress-related polynucleotides and polypeptides in plants
    Publication number: 20030217383
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 9, 2002
    Publication date: November 20, 2003
    Inventors: T. Lynne Reuber, Jose Luis Riechmann, Jacqueline E. Heard, Cai-Zhong Jiang, Luc J. Adam, Arnold N. DuBell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Human DNA Ligase III
    Publication number: 20030211582
    Abstract: A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
    Type: Application
    Filed: June 19, 2003
    Publication date: November 13, 2003
    Inventors: Ying-Fei Wei, Guo-Liang Yu, William A. Haseltine
  • 109 human secreted proteins
    Publication number: 20030204071
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 26, 2003
    Publication date: October 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Kenneth C. Carter, Yanggu Shi, Craig A. Rosen, Daniel R. Soppet, Hla Kyaw, Ying-Feig Wei, Kimberly Florence, Roxanne Duan, Charles Florence, John M. Greene, Ping Feng, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni
  • Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
    Publication number: 20030198640
    Abstract: The present invention encompasses methods for detection, diagnosis, prevention, treatment, and/or amelioration of inflammatory bowel diseases and disorders using TNF-gamma-&bgr; and its receptors DR3 and TR6. In particular the invention encompasses methods of using TNF-gamma-&bgr;, DR3 and TR6 polypeptides, as well as antibodies, and antagonists thereto, in the diagnosis, prognosis and treatment of ulcerative colitis and/or Crohn's disease. Methods of screening for antagonists of the TNF-gamma-&bgr; polypeptide, together with therapeutic uses of such antagonists are also disclosed.
    Type: Application
    Filed: December 6, 2002
    Publication date: October 23, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang, Ping Wei
  • Apoptosis inducing molecule II and methods of use
    Patent number: 6635743
    Abstract: The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: October 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Stephen Ullrich, Yifan Zhai
  • Antibodies to superoxide dismutase-4
    Patent number: 6635252
    Abstract: Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: October 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Craig A. Rosen, Claire M. Fraser, Jeannine D. Gocayne
  • Monoclonal antibodies to membrane neutrokine-&agr;
    Patent number: 6635482
    Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: October 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
  • Secreted protein HEMCM42
    Publication number: 20030195346
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 5, 2002
    Publication date: October 16, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • 207 human secreted proteins
    Publication number: 20030181692
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: August 22, 2001
    Publication date: September 25, 2003
    Inventors: Jian Ni, Reinhard Ebner, David W. LaFleur, Paul A. Moore, Henrik S. Olsen, Craig A. Rosen, Steven M. Ruben, Daniel R. Soppet, Paul E. Young, Yanggu Shi, Kimberly A. Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie L. Fischer, Ann M. Ferrie, Ping Fan, Ping Feng, Gregory A. Endress, Patrick J. Dillon, Kenneth C. Carter, Laurie A. Brewer, Guo-Liang Yu, Zhizhen Zeng, John M. Greene
  • 186 human secreted proteins
    Publication number: 20030175858
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 18, 2001
    Publication date: September 18, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • Neutrokine-alpha and neutrokine-alpha splice variant
    Publication number: 20030175208
    Abstract: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
    Type: Application
    Filed: October 16, 2002
    Publication date: September 18, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen, Stephen Ullrich, Michael Laird
  • Death domain containing receptors
    Publication number: 20030170203
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Application
    Filed: July 5, 2002
    Publication date: September 11, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz, Patrick J. Dillon
  • Human cystatin E polynucleotides
    Patent number: 6617132
    Abstract: Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: September 9, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Guo-Liang Yu, Craig A. Rosen
  • Human tumor necrosis factor delta and epsilon
    Publication number: 20030166864
    Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Application
    Filed: October 11, 2002
    Publication date: September 4, 2003
    Inventors: Guo-Liang Yu, Jian Ni, Reiner Gentz
  • 101 human secreted proteins
    Publication number: 20030144492
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: July 16, 2002
    Publication date: July 31, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Roxanne Duan, Steven M. Ruben, Kimberly A. Florence, John M. Greene, Craig A. Rosen, Paul Young, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni, Kenneth C. Carter, Gregory A. Endress, Ping Feng, David W. Lafleur, Yanggu Shi
  • Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
    Patent number: 6599719
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: July 29, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen
  • Tumor necrosis factor-gamma
    Publication number: 20030129189
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Application
    Filed: August 23, 2002
    Publication date: July 10, 2003
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
  • Stress-induced polynucleotides
    Publication number: 20030131386
    Abstract: Recombinant polynucleotides and methods for altering the regulation of gene expression in plants are provided to modify a plant's traits.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 10, 2003
    Inventors: Raymond Samaha, Jacqueline Heard, Cai-Zhong Jiang, Omaira Pineda, Lynne Reuber, Jose Luis Riechmann, Guo-Liang Yu, James Keddie, Oliver Ratcliffe, Marsha Pilgrim, Luc Adam, Pierre Broun, James Zhang
  • Secreted protein HODAZ50
    Patent number: 6590075
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: July 8, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi