Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytostatin II
    Patent number: 6746674
    Abstract: The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: June 8, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
  • Death domain containing receptor 5
    Patent number: 6743625
    Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: June 1, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Guo-Liang Yu, Craig A. Rosen
  • RPS gene family, primers, probes, and detection method
    Publication number: 20040088756
    Abstract: The invention relates to a method of identifying a plant disease-resistance gene that includes the steps of (a) providing a plant tissue sample, (b)introducing by biolistic transformation into the plant tissue sample a candidate plant disease-resistance gene; (c) expressing the candidate plant disease-resistance gene within the plant tissue sample; and (d) determining whether the plant tissue sample exhibits a disease-resistance response, whereby a response identifies a plant disease-resistance gene.
    Type: Application
    Filed: July 2, 2003
    Publication date: May 6, 2004
    Inventors: Frederick M. Ausubel, Brian J. Staskawicz, Andrew F. Bent, Douglas Dahlbeck, Fumiaki Katagiri, Barbara N. Kunkel, Michael Nicholas Mindrinos, Guo-Liang Yu, Barbara Baker, Jeffrey Ellis, John Salmeron
  • Method of assaying Neutrokine-&agr; mRNA level
    Patent number: 6716576
    Abstract: The present invention relates to a novel Neutrokine-a, and a splice variant thereof designated Neutrokine-aSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-a and/or Neutrokine-aSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-a and/or Neutrokine-aSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-a and/or Neutrokine-aSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: April 6, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni
  • 20 Human secreted proteins
    Publication number: 20040063128
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 1, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, Guo-Liang Yu, Jian Ni, Ping Feng
  • Death domain containing receptors
    Patent number: 6713061
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: March 30, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Vishva M. Dixit, Reiner L. Gentz, Patrick J. Dillon
  • 95 human secreted proteins
    Publication number: 20040048304
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 3, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Guo-Liang Yu, Paul Young, Ping Feng, Daniel R. Soppet, Ying-Fei Wei, Gregory A. Endress, Roxanne Duan, Hla Kyaw, Reinhard Ebner, David W. LaFleur, Henrik Olsen, Yanggu Shi, Paul A. Moore
  • Polynucleotides and polypeptides in plants
    Publication number: 20040045049
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: April 10, 2003
    Publication date: March 4, 2004
    Inventors: James Zhang, Michael E. Fromm, Jacqueline E. Heard, Jose Luis Riechmann, Luc J. Adam, Pierre E. Broun, Omaira Pineda, T. Lynne Reuber, James S. Keddie, Guo-Liang Yu, Cai-Zhong Jiang, Raymond S. Samaha, Marsha L. Pilgrim, Robert A. Creelman, Arnold N. DuBell, Oliver Ratcliffe, Roderick Kumimoto, Bradley K. Sherman
  • 31 human secreted proteins
    Publication number: 20040030115
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 12, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, Ann M. Ferrie, Charles Florence, Paul E. Young, Guo-Liang Yu, Jian Ni
  • Polynucleotides encoding neutrokine-&agr;
    Patent number: 6689579
    Abstract: The present invention relates to a novel Neutrokine-&agr; protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-&agr; protein including soluble forms of the extracellular domain. Neutrokine-&agr; polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-&agr; activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: February 10, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni
  • 90 human secreted proteins
    Publication number: 20040023283
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 18, 2003
    Publication date: February 5, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie Brewer, Fouad Janat, Charles E. Birse
  • Biochemistry-related polynucleotides and polypeptides in plants
    Publication number: 20040019925
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 9, 2002
    Publication date: January 29, 2004
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, James Keddie, Marsha L. Pilgrim, Arnold N. DuBell, Cai-Zhong Jiang, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Polynucleotides and polypeptides in plants
    Publication number: 20040019927
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: February 25, 2003
    Publication date: January 29, 2004
    Inventors: Bradley K. Sherman, Jose Luis Riechmann, Cai-Zhong Jiang, Jacqueline E. Heard, Volker Haake, Robert A. Creelman, Oliver Ratcliffe, Luc J. Adam, T. Lynne Reuber, James Keddie, Pierre E. Broun, Marsha L. Pilgrim, Arnold N. DuBell, Omaira Pineda, Guo-Liang Yu
  • Tumor necrosis factor receptors 6 alpha & 6 beta
    Publication number: 20040013664
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6&agr; & -6&bgr; proteins. TNFR-6&agr; & -6&bgr; polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6&agr; & -6&bgr; activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: April 18, 2003
    Publication date: January 22, 2004
    Inventors: Reiner L. Gentz, Guo-Liang Yu, Jian Ni, Reinhard Ebner, Ping Feng, Steven M. Ruben
  • 53 human secreted proteins
    Publication number: 20040010132
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 30, 2001
    Publication date: January 15, 2004
    Inventors: Craig A. Rosen, Laurie A. Brewer, Roxanne D. Duan, Steven M. Ruben, Kimberly A. Florence, John M. Greene, Paul E. Young, Ann M. Ferrie, Guo-Liang Yu, Charles Florence, Reinhard Ebner, Henrik Olsen
  • Apoptosis inducing molecule II and methods of use
    Publication number: 20040009147
    Abstract: The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
    Type: Application
    Filed: February 28, 2003
    Publication date: January 15, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Yifan Zhai, Stephen Ullrich
  • Human tumor necrosis factor receptor TR9
    Patent number: 6667390
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: December 23, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Transgenic plants comprising polynucleotides encoding transcription factors that confer disease tolerance
    Patent number: 6664446
    Abstract: Plants transformed with a plant APZ transcription factor encoding polynucleotide, isolated from Arabidopsis, that enhances tolerance to fungal diseases, especially fungal diseases caused by Fusarium, Erysiphe, Sclerotinia and Botrytis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: December 16, 2003
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline Heard, Pierre Broun, Jose Luis Riechmann, James Keddie, Omaira Pineda, Luc Adam, Raymond Samaha, James Zhang, Guo-Liang Yu, Oliver Ratcliffe, Marsha Pilgrim, Cai-Zhong Jiang, Lynne Reuber
  • Plant gene sequences II
    Publication number: 20030229915
    Abstract: Compositions and methods are provided for modifying a trait of a plant. Isolated polynucleotide and polypeptide sequences are provided, along with an expression vector comprising the isolated polynucleotide, a host cell comprising the isolated polynucleotide, and a transgenic plant comprising the isolated polynucleotide. Also provided is a method for producing a transgenic plant, a method for screening for a compound that may modify the trait and a method for identifying other homologous polynucleotide and polypeptide sequences.
    Type: Application
    Filed: November 22, 2002
    Publication date: December 11, 2003
    Inventors: James Keddie, Michael Fromm, Jacqueline Heard, Jose Luis Riechmann, Luc Adam, Pierre Broun, Omaira Pineda, Lynne Reuber, James Zhang, Guo-Liang Yu, Cai-Zhong Jiang, Raymond Samaha, Marsha Pilgrim, Robert Creelman
  • 186 human secreted proteins
    Publication number: 20030225248
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: June 10, 2002
    Publication date: December 4, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw