Patents by Inventor Guo-Liang Yu

Guo-Liang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genes for modifying plant traits IV
    Publication number: 20030121070
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Application
    Filed: August 22, 2001
    Publication date: June 26, 2003
    Inventors: Luc Adam, James Keddie, Robert Creelman, Jose Luis Riechmann, Cai-Zhong Jiang, Jacqueline Heard, Marsha L. Pilgrim, Arnold Dubell, Oliver Ratcliffe, T. Lynne Reuber, Guo-Liang Yu, Omaira Pineda
  • Human cystatin F
    Publication number: 20030114646
    Abstract: The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Application
    Filed: December 27, 2002
    Publication date: June 19, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Guo-Liang Yu, Reiner L. Gentz, Jian Ni
  • Human cystatin F antibodies
    Patent number: 6576745
    Abstract: The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: June 10, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Guo-Liang Yu, Reiner L. Gentz, Jian Ni
  • Secreted protein HEMCM42
    Publication number: 20030105297
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 5, 2002
    Publication date: June 5, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • Methods and compositions for treating metabolic bone diseases relating to human endokine alpha
    Publication number: 20030100074
    Abstract: The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.
    Type: Application
    Filed: August 15, 2002
    Publication date: May 29, 2003
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Bernardetta Nardelli
  • Secreted protein HEMAE80
    Publication number: 20030092893
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 20, 2001
    Publication date: May 15, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
  • Polynucleotides for seed trait alteration
    Publication number: 20030093837
    Abstract: Recombinant polynucleotides and methods for altering the regulation of plant gene expression are provided. In this manner, a plant's traits may be altered.
    Type: Application
    Filed: November 1, 2002
    Publication date: May 15, 2003
    Inventors: James Keddie, Jose Luis Riechmann, Oliver Ratcliffe, James Zhang, Cai-Zhong Jiang, Omaira Pineda, Jacqueline Heard, Guo-Liang Yu, Luc Adam, Pierre Broun, Lynne Reuber, Marsha Pilgrim, Raymond Samaha
  • Diagnostic methods using antibodies to Neutrokine-alpha
    Patent number: 6562579
    Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: May 13, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
  • DEATH DOMAIN CONTAINING RECEPTORS
    Publication number: 20030077694
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Application
    Filed: May 19, 1999
    Publication date: April 24, 2003
    Inventors: GUO-LIANG YU, JIAN NI, VISHVA DIXIT, REINER L. GENTZ, PATRICK J. DILLON
  • Secreted protein HEMAE80
    Publication number: 20030065160
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 7, 2001
    Publication date: April 3, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
  • Tumor necrosis factor delta polypeptides
    Patent number: 6541224
    Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: April 1, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz, Patrick J. Dillon
  • Polynucleotides for root trait alteration
    Publication number: 20030061637
    Abstract: Recombinant polynucleotides and methods for altering the regulation of plant gene expression are provided. In this manner, a plant's trait may be altered.
    Type: Application
    Filed: October 21, 2002
    Publication date: March 27, 2003
    Inventors: Cai-Zhong Jiang, Pierre Broun, Jose Luis Riechmann, Omaira Pineda, James Zhang, Guo-Liang Yu, Marsha Pilgrim, James Keddie, Jacqueline Heard, Lynne Reuber, Oliver Ratcliffe, Luc Adam, Raymond Samaha
  • Secreted protein HKABT24
    Publication number: 20030055236
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 14, 2002
    Publication date: March 20, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Kenneth C. Carter, Yanggu Shi, Craig A. Rosen, Daniel R. Soppet, Hla Kyaw, Ying-Feig Wei, Kimberly A. Florence, D. Roxanne Duan, Charles Florence, John M. Greene, Ping Feng, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni
  • 90 human secreted proteins
    Publication number: 20030054443
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 4, 2001
    Publication date: March 20, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat, Charles E. Birse
  • 186 human secreted proteins
    Publication number: 20030049618
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 64 human secreted proteins
    Publication number: 20030050455
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: February 6, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul E. Young, John M. Greene, Jian Ni, Ping Feng, Kimberly A. Florence, Jing-Shan Hu, Ann M. Ferrie, Guo-Liang Yu, Roxanne D. Duan, Fouad Janat
  • Secreted protein HEMCM42
    Patent number: 6531447
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: March 11, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • 67 Human secreted proteins
    Publication number: 20030045459
    Abstract: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 21, 2001
    Publication date: March 6, 2003
    Inventors: Steven M. Ruben, Ann M. Ferrie, Craig A. Rosen, Kimberly A. Florence, Kenneth C. Carter, Daniel R. Soppet, Guo-Liang Yu, Charles Florence, Paul E. Young, Jian Ni, Gregory A. Endress, Ping Feng, Fouad Janat
  • TRANSGENIC PLANTS COMPRISING POLYNUCLEOTIDES ENCODING TRANSCRIPTION FACTORS THAT CONFER DISEASE TOLERANCE
    Publication number: 20030046723
    Abstract: Recombinant polynucleotides and methods for altering the regulation of gene expression in plants are provided to modify a plant's traits, in particular disease tolerance.
    Type: Application
    Filed: March 22, 2000
    Publication date: March 6, 2003
    Inventors: Jacqueline Heard, Pierre Broun, Jose Luis Riechmann, James Keddie, Omaira Pineda, Luc Adam, Raymond Samaha, James Zhang, Guo-Liang Yu, Oliver Ratcliffe, Marsha Pilgrim, Cai-Zhong Jiang, Lynne Reuber
  • Precerebellin-like protein
    Patent number: 6525174
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: February 25, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter