Patents by Inventor Gustavo A. Stolovitzky

Gustavo A. Stolovitzky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9453831
    Abstract: A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.
    Type: Grant
    Filed: April 21, 2012
    Date of Patent: September 27, 2016
    Assignee: GlobalFoundries Inc.
    Inventors: Stanislav Polonsky, Ali Afzali-Ardakani, Hongbo Peng, Gustavo A. Stolovitzky, Ajay A. Royyuru, Mark N. Wegman
  • Publication number: 20160220996
    Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.
    Type: Application
    Filed: April 12, 2016
    Publication date: August 4, 2016
    Inventors: Jingwei Bai, Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang
  • Publication number: 20160209394
    Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
    Type: Application
    Filed: March 30, 2016
    Publication date: July 21, 2016
    Inventors: Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Publication number: 20160199833
    Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
    Type: Application
    Filed: March 18, 2016
    Publication date: July 14, 2016
    Inventors: Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Patent number: 9364832
    Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: June 14, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Publication number: 20160144405
    Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities are sorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.
    Type: Application
    Filed: April 27, 2015
    Publication date: May 26, 2016
    Inventors: Yann A. Astier, Joshua T. Smith, Gustavo A. Stolovitzky, Chao Wang, Benjamin H. Wunsch
  • Publication number: 20160144406
    Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities are sorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 26, 2016
    Inventors: Yann A. Astier, Joshua T. Smith, Gustavo A. Stolovitzky, Chao Wang, Benjamin H. Wunsch
  • Publication number: 20160146718
    Abstract: A technique relates sorting biopolymers. The biopolymers are introduced into a nanopillar array, and the biopolymers include a first population and a second population. The nanopillar array includes nanopillars arranged to have a gap separating one from another. The biopolymers are sorted through the nanopillar array by transporting the first population of the biopolymers less than a predetermined bumping size according to a fluid flow direction and by transporting the second population of the biopolymers at least the predetermined bumping size according to a bumped direction different from the fluid flow direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the biopolymers.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 26, 2016
    Inventors: Yann A. Astier, Joshua T. Smith, Gustavo A. Stolovitzky, Chao Wang, Benjamin H. Wunsch
  • Publication number: 20160146778
    Abstract: A technique relates sorting biopolymers. The biopolymers are introduced into a nanopillar array, and the biopolymers include a first population and a second population. The nanopillar array includes nanopillars arranged to have a gap separating one from another. The biopolymers are sorted through the nanopillar array by transporting the first population of the biopolymers less than a predetermined bumping size according to a fluid flow direction and by transporting the second population of the biopolymers at least the predetermined bumping size according to a bumped direction different from the fluid flow direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the biopolymers.
    Type: Application
    Filed: April 27, 2015
    Publication date: May 26, 2016
    Inventors: Yann A. Astier, Joshua T. Smith, Gustavo A. Stolovitzky, Chao Wang, Benjamin H. Wunsch
  • Patent number: 9346052
    Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: May 24, 2016
    Assignee: International Business Machine Corporation
    Inventors: Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Publication number: 20160139105
    Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.
    Type: Application
    Filed: January 25, 2016
    Publication date: May 19, 2016
    Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
  • Patent number: 9322061
    Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 26, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Jingwei Bai, Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Patent number: 9290806
    Abstract: A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 22, 2016
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Gustavo A. Stolovitzky, Deqiang Wang
  • Patent number: 9285339
    Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 15, 2016
    Assignee: International Business Machines Corporation
    Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
  • Patent number: 9235808
    Abstract: Disclosed is a novel system, and method to evaluate a prediction of a possibly unknown outcome out of a plurality of predictions of that outcome. The method begins with accessing a particular prediction of an outcome out of a plurality of predictions of that outcome in which the outcome may be unknown. Next, a subsample of the plurality of predictions of the outcome is accessed. The subsample can possibly include the particular prediction. A consensus prediction of the outcome based on the subsample of the plurality of predictions is determined. A proximity of the particular prediction to the consensus prediction is determined. Each prediction is ranked out of the plurality of predictions in an order of a closest in proximity to the consensus prediction to a farthest in proximity to the consensus prediction.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 12, 2016
    Assignee: International Business Machines Corporation
    Inventors: Erhan Bilal, Gustavo Stolovitzky
  • Patent number: 9222930
    Abstract: A mechanism is provided for forming a nanodevice. A reservoir is filled with a conductive fluid, and a membrane is formed to separate the reservoir in the nanodevice. The membrane includes an electrode layer having a tunneling junction formed therein. The membrane is formed to have a nanopore formed through one or more other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. The tunneling junction of the electrode layer is narrowed to a narrowed size by electroplating or electroless deposition. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: December 29, 2015
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Deqiang Wang
  • Patent number: 9201057
    Abstract: A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric fields of the Paul trap device position the molecule to a nanopore in the nanopore device. A first voltage is applied to the nanopore device to capture the molecule in the nanopore of the nanopore device.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: December 1, 2015
    Assignee: International Business Machines Corporation
    Inventors: Hongbo Peng, Gustavo A. Stolovitzky, Deqiang Wang
  • Patent number: 9194860
    Abstract: A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric fields of the Paul trap device position the molecule to a nanopore in the nanopore device. A first voltage is applied to the nanopore device to capture the molecule in the nanopore of the nanopore device.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: November 24, 2015
    Assignee: International Business Machines Corporation
    Inventors: Hongbo Peng, Gustavo A. Stolovitzky, Deqiang Wang
  • Publication number: 20150323490
    Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.
    Type: Application
    Filed: May 7, 2014
    Publication date: November 12, 2015
    Applicant: International Business Machines Corporation
    Inventors: Binquan Luan, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
  • Publication number: 20150285764
    Abstract: A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.
    Type: Application
    Filed: December 30, 2014
    Publication date: October 8, 2015
    Inventors: Gustavo A. Stolovitzky, George F. Walker, Chao Wang, Deqiang Wang