Abstract: Methods and compositions for treating a corneal wound and/or increasing a population of limbal epithelial stem cells (LESCs) and/or early transit amplifying cells (eTAs) in the limbal epithelium of a subject in need thereof. The methods can include administering a therapeutic agent to the subject that: i) results in an increase in concentration of IFITM1 (Interferon Induced transmembrane Protein 1) in the limbal epithelium of the subject; and/or ii) results in a decrease in concentration of OVOL1 (Ovo Like Zinc Finger 1) in the limbal epithelium of the subject. Also provided are adeno-associated viruses (AAVs). The AAVs comprise a heterologous nucleic acid sequence encoding IFITM1 or a variant thereof, operably linked to a regulatory sequence.

Abstract: A semiconductor apparatus and a method of manufacturing the same are provided. A semiconductor apparatus includes a first nitride semiconductor layer, a second nitride semiconductor layer, an electrode, a dielectric structure, a field plate, a plurality of height compensators, and a plurality of vias. The second nitride semiconductor layer is on the first nitride semiconductor layer and has a bandgap greater than that of the first nitride semiconductor layer. The electrode contacts the second nitride semiconductor layer. The dielectric structure is disposed on the second nitride semiconductor layer and covers the electrode. The field plate is in the dielectric structure. The height compensators are in the dielectric structure and are disposed on the electrode and the field plate, respectively. The vias extend into the dielectric structure and contact top surfaces of the height compensators, respectively.

Abstract: Disclosed herein are compositions comprising synthetic nanoparticles and methods of use thereof for reducing inflammation of the eye and/or skin.

Abstract: A breeding method for improving reproductive performance of a chicken specialized dam line includes the steps of forming an F1 generation group, forming a breeding group, screening a breeding group, forming an F2 generation group, and continuously breeding to an Fn generation group. The method includes raising in small-scale groups and natural mating for systematic selection and breeding, which effectively reduces the generation interval and has the features of easy operation and fast genetic progress, not only ensuring animal welfare, but also effectively improving production performance.

Abstract: Disclosed herein are nanostructures, compositions, and methods for treating ocular disorders, injuries, and infections using RNA complexed nanoparticles (e.g., RNA-templated lipoprotein particles, miRNA-high density lipoprotein particles). These nanostructures are contemplated in topical therapies.

Abstract: This disclosure regards a magnetic resonance imaging system including a scanner, and gradient drivers. The scanner is to be implemented within a scan room that is shielded from electromagnetic interference. Gradient coils are designed to create a linear gradient in the magnetic field generated in the scanner by a primary magnet. These coils are energized by gradient drivers. The gradient drivers use transformers and other electrical devices in a switching stage configured to generate pulse-width-modulated power. The transformers may have non-magnetic cores to facilitate implementing the gradient drivers within the scan room. The gradient drivers also use a filtering stage which uses inductors and other electrical devices to smooth the pulse-width-modulated power. The inductors within the filters may have non-magnetic cores to facilitate implementing the gradient driver within the scan room. Additionally, an inductor with a hollow wire may be used to circulate fluid to facilitate cooling the gradient driver.

Abstract: A breeding method for improving reproductive performance of a chicken specialized dam line includes the steps of forming an F1 generation group, forming a breeding group, screening a breeding group, forming an F2 generation group, and continuously breeding to an Fn generation group. The method includes raising in small-scale groups and natural mating for systematic selection and breeding, which effectively reduces the generation interval and has the features of easy operation and fast genetic progress, not only ensuring animal welfare, but also effectively improving production performance.

Abstract: This disclosure regards a magnetic resonance imaging system including a scanner, and gradient drivers. The scanner is to be implemented within a scan room that is shielded from electromagnetic interference. Gradient coils are designed to create a linear gradient in the magnetic field generated in the scanner by a primary magnet. These coils are energized by gradient drivers. The gradient drivers use transformers and other electrical devices in a switching stage configured to generate pulse-width-modulated power. The transformers may have non-magnetic cores to facilitate implementing the gradient drivers within the scan room. The gradient drivers also use a filtering stage which uses inductors and other electrical devices to smooth the pulse-width-modulated power. The inductors within the filters may have non-magnetic cores to facilitate implementing the gradient driver within the scan room. Additionally, an inductor with a hollow wire may be used to circulate fluid to facilitate cooling the gradient driver.

Abstract: This disclosure regards a magnetic resonance imaging system including a scanner, and gradient drivers. The scanner is to be implemented within a scan room that is shielded from electromagnetic interference. Gradient coils are designed to create a linear gradient in the magnetic field generated in the scanner by a primary magnet. These coils are energized by gradient drivers. The gradient drivers use transformers and other electrical devices in a switching stage configured to generate pulse-width-modulated power. The transformers may have non-magnetic cores to facilitate implementing the gradient drivers within the scan room. The gradient drivers also use a filtering stage which uses inductors and other electrical devices to smooth the pulse-width-modulated power. The inductors within the filters may have non-magnetic cores to facilitate implementing the gradient driver within the scan room. Additionally, an inductor with a hollow wire may be used to circulate fluid to facilitate cooling the gradient driver.

Abstract: An ultrasound pulse generator circuit includes a first gate driver electrically coupled to a first gallium nitride (GaN) transistor, a second gate driver electrically coupled to a second GaN transistor, a first snubber circuit, a second snubber circuit, and a transformer. The first snubber circuit and the second snubber circuit each include a respective capacitor and resistor and each snubber circuit is configured to clamp a voltage overshoot when present. Further, the transformer generates an output signal when operated and the third transformer is electrically connected downstream of the first GaN transistor, the second GaN transistor, the first snubber circuit, and the second snubber circuit. In addition, the transformer includes multiple windings.

Abstract: Systems and methods provided herein relate to a gate drive circuit for controlling operation of a wide bandgap semiconductor switch. The systems and methods receive a control signal and configuring an operation signal configured to activate a wide bandgap switch (WBG switch). A profile of the operation signal being based on electrical characteristics of first and second shaping circuits. The systems and methods further deliver the operation signal to the WBG switch.

Abstract: This disclosure regards a magnetic resonance imaging system including a scanner, and gradient drivers. The scanner is to be implemented within a scan room that is shielded from electromagnetic interference. Gradient coils are designed to create a linear gradient in the magnetic field generated in the scanner by a primary magnet. These coils are energized by gradient drivers. The gradient drivers use transformers and other electrical devices in a switching stage configured to generate pulse-width-modulated power. The transformers may have non-magnetic cores to facilitate implementing the gradient drivers within the scan room. The gradient drivers also use a filtering stage which uses inductors and other electrical devices to smooth the pulse-width-modulated power. The inductors within the filters may have non-magnetic cores to facilitate implementing the gradient driver within the scan room. Additionally, an inductor with a hollow wire may be used to circulate fluid to facilitate cooling the gradient driver.

Abstract: There is set forth herein an ultrasound signal generating circuit having a control circuit which can include a control circuit having a control signal generating circuit; a low power signal driver circuit for providing a low power ultrasound signal; a high power signal driver circuit for providing a high power ultrasound signal; and a radiofrequency switch configured to transmit the low power ultrasound signal and the high power ultrasound signal to the ultrasound probe, wherein the radiofrequency switch isolates the low power signal driver circuit from the high power signal driver circuit; wherein the ultrasound signal generating circuit is configured so that the radiofrequency switch transmits an output low power ultrasound signal output by the low power signal driver circuit or an output high power ultrasound signal output by the high power signal driver circuit based on an output of the control signal generating circuit.

Abstract: An ultrasound pulse generator circuit includes a first gate driver electrically coupled to a first gallium nitride (GaN) transistor, a second gate driver electrically coupled to a second GaN transistor, a first snubber circuit, a second snubber circuit, and a transformer. The first snubber circuit and the second snubber circuit each include a respective capacitor and resistor and each snubber circuit is configured to clamp a voltage overshoot when present. Further, the transformer generates an output signal when operated and the third transformer is electrically connected downstream of the first GaN transistor, the second GaN transistor, the first snubber circuit, and the second snubber circuit. In addition, the transformer includes multiple windings.

Abstract: Systems and methods provided herein relate to a gate drive circuit for controlling operation of a wide bandgap semiconductor switch. The systems and methods receive a control signal and configuring an operation signal configured to activate a wide bandgap switch (WBG switch). A profile of the operation signal being based on electrical characteristics of first and second shaping circuits. The systems and methods further deliver the operation signal to the WBG switch.

Abstract: A universal power adapter includes a power converter configured to generate an output power based on a switching frequency of the power converter. The universal power adapter also includes a frequency controller operatively coupled to the power converter and configured to control the switching frequency of the power converter. The universal power adapter further includes a switch capacitor circuit having a plurality of capacitive elements, operatively coupled to the power converter. The switch capacitor circuit is configured to switch between the plurality of capacitive elements. The universal power adapter also includes a capacitance controller operatively coupled to the switch capacitor circuit and configured to control the switch capacitor circuit to control switching between the plurality of capacitive elements to maintain a control parameter within a threshold range of.

Abstract: A universal power adapter includes a power converter configured to generate an output power based on a switching frequency of the power converter. The universal power adapter also includes a frequency controller operatively coupled to the power converter and configured to control the switching frequency of the power converter. The universal power adapter further includes a switch capacitor circuit having a plurality of capacitive elements, operatively coupled to the power converter. The switch capacitor circuit is configured to switch between the plurality of capacitive elements. The universal power adapter also includes a capacitance controller operatively coupled to the switch capacitor circuit and configured to control the switch capacitor circuit to control switching between the plurality of capacitive elements to maintain a control parameter within a threshold range of.

Abstract: Method and compositions for reducing the inflammation after cytokine exposure of an islet cell transplant without affecting the viability and potency are disclosed herein. The present invention describes a composition comprising Withaferin A (WA), a steroidal lactone derived from Withania somnifera to effectively block NF-kB activation in beta cells, minimize cytokine-induced cell death and improve survival of transplanted islets. The method of the present invention involves identifying a subject having islet cells in need of treatment; and providing a effective amount of a Withaferin A composition disposed in a pharmaceutically acceptable carrier in an amount sufficient to reduce the inflammation after cytokine exposure without affecting the viability and potency of the islet cell population.

Abstract: Method and compositions for reducing the inflammation after cytokine exposure of an islet cell transplant without affecting the viability and potency are disclosed herein. The present invention describes a composition comprising Withaferin A (WA), a steroidal lactone derived from Withania somnifera to effectively block NF-kB activation in beta cells, minimize cytokine-induced cell death and improve survival of transplanted islets. The method of the present invention involves identifying a subject having islet cells in need of treatment; and providing a effective amount of a Withaferin A composition disposed in a pharmaceutically acceptable carrier in an amount sufficient to reduce the inflammation after cytokine exposure without affecting the viability and potency of the islet cell population.

Abstract: A method for limiting the transmission of light through a material is disclosed. In the method, a layer composed of a hyperbranched polymer formed via a copolycyclotrimerization reaction is interposed between a light source and the material. Also provided is a method for emitting light comprising exciting the hyperbranched polymer. In addition, methods for limiting the transmission of light and for emitting light using hyperbranched polymers formed by homopolycyclotrimerization reactions are disclosed. A new class of hyperbranched polymers produced by copolycyclotrimerization is also disclosed.