Abstract: The present disclosure includes MGMT modifications that cause MGMT resistance to MGMT inhibitors. The present disclosure also includes in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids to encode and express an MGMT variant that is resistant to MGMT inhibitors. Inhibitor-resistant MGMT modifications and modification of an MGMT-encoding nucleic can occur or be used in conjunction with a therapeutic modification, e.g., in a single cell. Expression of inhibitor-resistant MGMT can selectively protect modified cells from a selection regimen, such as a selection regimen including an MGMT inhibitor and an alkylating agent. Accordingly, in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids can be used in gene therapy to select for modified cells.

Abstract: The present disclosure relates to food-grade bacteria (GRAS isolates) and methods for removing glyphosate and other toxic compounds preventing the accumulation within organisms, feed, food and the environment. Food grade bacteria for the degradation, removal, sequestration or inactivation of glyphosate are disclosed.

Abstract: A method for learning disentangled representations of videos is presented. The method includes feeding each frame of video data into an encoder to produce a sequence of visual features, passing the sequence of visual features through a deep convolutional network to obtain a posterior of a dynamic latent variable and a posterior of a static latent variable, sampling static and dynamic representations from the posterior of the static latent variable and the posterior of the dynamic latent variable, respectively, concatenating the static and dynamic representations to be fed into a decoder to generate reconstructed sequences, and applying three regularizers to the dynamic and static latent variables to trigger representation disentanglement. To facilitate the disentangled sequential representation learning, orthogonal factorization in generative adversarial network (GAN) latent space is leveraged to pre-train a generator as a decoder in the method.

Abstract: A processing method and apparatus for ultrafast laser deposition of a multilayer film including a diamond-like carbon film, an anti-reflection film and an anti-fingerprint film includes: generating primary plasma by first excitement on a target material with a femtosecond or picosecond pulsed laser beam as a pre-pulse; and generating secondary plasma by second excitement on the target material under plasma grating, formed by allowing two femtosecond pulsed laser beams to intersect at a small include angle for interaction in the primary plasma, for deposition to coat a film.

Abstract: Systems, methods, and computer programs for monitoring the disease progression of a Parkinson's patient are provided. Specifications for a Parkinson's patient may defined in a computer system by a physician. The specifications may contain threshold values. At repeating points in time, a message may including a request to perform a mobility test may be output by the computer system to the patient. Mobility parameters may be determined as a result of the performance of the mobility test. The mobility parameters may be compared with the threshold values to determine one or more deviations between the one or more mobility parameters and the one or more threshold values. The mobility parameters, the deviations, or a combination thereof may be made available to the physician by outputting or storing the mobility parameters or the deviations or by transmitting the mobility parameters or the deviations to a separate computer system.

Abstract: A method for monitoring overburden during excavation in soil, in which the soil pressure exerted by the soil (10) on an excavation device driven through the soil (10) is monitored by means of a pressure control element (5) extended from the circumference (3) of the driving device. An excavation device for carrying out the method has a pressure control element (5) which is arranged on the circumference (3) of the excavation device and can be extended beyond the circumference (3) of the excavation device.

Abstract: Rotor blade (20) to be arranged in a gas conduit (3) of a turbomachine (1), having a rotor blade airfoil (23), which radially inwardly has a chord length Si, radially outwardly has a chord length Sa, and in a radial position rx inbetween has a chord length Sx, the chord length Sx in the radial position rx being at least equal to the chord length Si radially inwardly (Si<Sx), and the chord length Sa radially outwardly corresponding at most 0.9 times the chord length Sx in the radial position rx inbetween (Sa<0.9 Sx).

Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.

Abstract: The present invention relates to cultivated cucumber plants comprising modifications in their genome, whereby the modifications confer reduced susceptibility to internal fruit rot symptoms caused by Didymella bryoniae, and to methods for generating such plants, and their use.

Abstract: The present invention relates to a web-shaped adhesive compound which contains at least one poly(meth)acrylate and optionally at least one synthetic rubber; and at least one polyurethane- and/or silicone-based filler. The invention also relates to a process for preparing such an adhesive compound and to the use thereof. The invention further relates to the use of polyurethane- and/or silicone-based fillers for increasing the adhesive power of adhesive compounds containing at least one poly(meth)acrylate and optionally at least one synthetic rubber and/or for increasing the shock performance of such adhesive compounds with respect to adhesive compounds which do not contain any polyurethane- and/or silicone-based filler.

Abstract: A removable insect trap portion includes a front housing comprising a convex outward-facing surface and a concave inner-facing surface; a protrusion configured to engage with a base portion; an adhesive surface configured to adhere to a flying insect, wherein the adhesive surface engages a bottom portion of the front housing and extends from the bottom portion to a top portion of the front housing; a cup joined to the front housing, wherein the cup includes a bottom surface, an open end, and a lip protruding from a perimeter of the open end; and a removable tab having a sealing end and a grip end. The sealing end is affixed to the lip of the cup and configured to cover the open end of the cup creating a seal between the lip and the sealing end of the removable tab. An insect-attracting substance is contained within the cup.

Abstract: A valve for a packaging container includes at least one base film (10) with an opening (11), at least one frame film (13) encompassing a free region (17), wherein the frame film (13) is connected to the base film (10), wherein at least one membrane (12) is provided, which is arranged on the base film (10) and covers the opening (11), wherein a fluid is provided between the membrane (12) and the base film (10), wherein the membrane (12) is arranged movably within the free region (17) on the base film (10).

Abstract: The present invention relates to a ball, in particular a soccer ball, comprising: a shell with a plurality of panels on an outside of the shell, wherein the plurality of panels are arranged in such a way that there is a gap between two adjacent panels, and wherein the gap is at least partly filled with a filling material.

Abstract: The invention relates to substituted heterocycles of the general formula I, and the use of the compounds of the present invention for the treatment and/or prevention of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

Abstract: A system includes two or more phosphor-containing white LEDs (or other color-shifting artificial light sources) selected so that their combined color shift over at least 8,000 hours (e.g., at least 10,000 hours, at least 20,000 hours, at least 30,000 hours, at least 40,000 hours, up to 200,000 hours, up to 100,000 hours, up to 80,000 hours) of operation is less than at least one of the LED's (or the other color-shifting artificial light source's) color shift over that time. Here, the combined color shift (?u?v?) over the at least 8,000 hours (e.g., at least 10,000 hours, at least 20,000 hours, at least 30,000 hours, at least 40,000 hours, up to 200,000 hours, up to 100,000 hours, up to 80,000 hours) of operation can be less than 0.007 (e.g., 0.006 or less, 0.005 or less, 0.004 or less, 0.003 or less, 0.002 or less, 0.001 or less, 0.0005 or less).

Abstract: The invention relates to a method for managing information dealing with a medical test for assessing a predetermined medical condition by means of a distributed system (100) comprising a plurality of communication devices (210, 312, 322, 410), the method comprising obtaining by a user communication device (210) information on an access code provided in a test-kit for assessing a predetermined medical condition, the user communication device (210) being configured for receiving and displaying messages addressed to a unique identifier. Further, the method comprises providing instructions relating to analysis of the medical sample. A negative analysis result is communicated to the user communication device (210) of the user. In case of a positive analysis result, consultation by a medical entity is established. Further aspects relate to a user communication device, a computer program product, a central server and a medical test-kit for use with the proposed method.

Abstract: Described is a heating plate having a substrate made of metal, a heating layer and an insulation layer which is arranged between the heating layer and the substrate. It is provided according to this disclosure that the insulation layer bears an electrically conductive shielding layer and that the shielding layer is covered by a second insulation layer on which the heating layer lies. In addition, a flow heater having such a heating plate is disclosed.

Abstract: An adhesive film includes a first (meth)acrylate copolymer containing at least 55 weight percent (wt. %) of linear or branched alkyl (meth)acrylate monomer units, from 15 to 40 wt. % of (meth)acrylic acid monomer units, and 0.1 to 5 wt. % of monomer units of a crosslinking monomer having more than one (meth)acrylate group. If the first (meth)acrylate copolymer comprises 15 wt. % (meth)acrylic acid monomer units, the first (meth)acrylate copolymer comprises at least five wt. % monomer units of a high Tg monomer. The adhesive film comprises not more than five wt. % of a further (meth)acrylate copolymer comprising from 0.1 to 15 wt. % of (meth)acrylic acid monomer units. The adhesive film can be a multilayer adhesive assembly including a first layer of the first (meth)acrylate copolymer and a second adhesive layer adjacent to the first layer. A process for making and a system including the adhesive film and a primer are also described.

Abstract: A backlit vehicle-trim part, in particular a vehicle badge, comprising a three-dimensionally shaped film-like visible part (3) made of plastic, which can be at least partially transilluminated and the visible side of which forms the externally visible trim part or vehicle badge, and a light housing (15), which is arranged on the rear side of the visible part (3), contains one or more light elements (18, 19) and is connected to the visible part, wherein the film-like visible part (3) is connected to the light housing (15) in an in-mold back-molding operation.

Abstract: A hydraulic power unit includes a reservoir containing hydraulic fluid, a main output, a pressure sensor, at least one active valve hydraulic pump and at least one passive valve hydraulic pump. A main flow of the hydraulic fluid is discharged through the main output. The pressure sensor includes a pressure signal that is indicative of a pressure of the main flow. Each active valve hydraulic pump is configured to drive a first flow portion of the main flow from the reservoir to the main output when the pressure signal is below a first pressure setpoint. Each passive valve hydraulic pump is configured to drive a second flow portion of the main flow from the reservoir to the main output when the pressure signal is below a second pressure setpoint.