Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.

Abstract: Two-component paint system comprising a binding agent component and a curing agent component which are separated from one another prior to application of the paint system and are brought into contact with one another for application, so that the binding agent in the binder component crosslinks by contact with the curing agent component, with the binder component containing, in addition to the binding agent, at least one solvent which is unreactive with the curing agent component, a crosslinking catalyst and a propellant agent, characterized in that the curing agent component is obtainable by pre-reaction of a deficient amount of a bi- or trifunctional low-molecular-weight active hydrogen-carrying compound with an isocyanate-based crosslinker having a residual content of monomeric or dimeric isocyanates of ?1% w/w, said paint system being contained in a 2K aerosol spray can provided with an inner casing.

Abstract: Exemplary embodiments are directed to wireless charging and wireless power alignment of wireless power antennas associated with a vehicle. A wireless power charging apparatus includes an antenna including first and second orthogonal magnetic elements for detecting a horizontal component of a magnetic field generated from a second charging base antenna. A processor determines a directional vector between the antennas.

Abstract: A method for determining a temperature compensation parameter for compensation of temperature effects on measured values of a sensor system having a sensor unit for acquiring measured values of a sensor measuring variable.

Abstract: In certain aspects, an enclosure for a wireless power transfer pad is disclosed. The enclosure includes a cover shell configured to be positioned over a portion of the wireless power transfer pad configured to face a wireless power receiver when wirelessly transferring power, wherein at least a portion of the cover shell is made of a heat resistant material.

Abstract: The present invention relates to a method for producing a protein hydrolysate using a polypeptide having endopeptidase activity and a polypeptide having carboxypeptidase activity and the use of these enzymes for hydrolysing a protein substrate. In addition, the present invention relates to polypeptides having carboxypeptidase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: A means of transport, in particular a pedelec, which can be driven by means of drive energy produced electromotively and by human muscular power, comprising a drive unit in which an electric drive motor and a harmonic drive transmission are nested one inside the other, thereby saving space.

Abstract: A field effect transistor (FET) is proposed. The FET includes a transistor cell area in a silicon carbide (SiC) semiconductor body. An edge termination area surrounds the transistor cell area. A source contact is arranged over a first surface of the SiC semiconductor body. A drain contact is arranged on a second surface of the SiC semiconductor body. The FET further includes a drift region of a first conductivity type between the first surface and the second surface. Along a lateral direction, a net doping concentration in the drift region is larger in the transistor cell area than in the edge termination area.

Abstract: Exemplary embodiments are directed to wireless charging and wireless power alignment of wireless power antennas associated with a vehicle. A wireless power charging apparatus includes an antenna including first and second orthogonal magnetic elements for detecting a horizontal component of a magnetic field generated from a second charging base antenna. A processor determines a directional vector between the antennas.

Abstract: Embodiments relate to a test method for testing an unpopulated printed circuit board. The method can involve the steps of: exposing the unpopulated printed circuit board to temperatures of a reflow soldering process in a first step; and testing the electrical connections of the unpopulated printed circuit board. Embodiments also relate to a test device and a method for producing populated printed circuit boards.

Abstract: A valve for a packaging container is proposed, wherein the valve comprises at least one base film (10) with an opening (11), at least one frame film (13) encompassing a free region (17), and at least one membrane (12) which is arranged on the base film (10) and covers the opening (11), wherein a fluid is provided between the membrane (12) and the base film (10), wherein the membrane (12) is connected to a surrounding film (20) via at least one connection region (22), the surrounding film (20) being connected on one side to the base film (10) and on its other side to the frame film (13) and the membrane (12) being arranged movably within the free region (17), wherein the surrounding film (20) is open at least in one point, such that a channel (18) is formed.

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

Abstract: Provided herein are compositions and methods for treating and/or ameliorating the FOXG1 syndromes or the symptoms associated therewith. The compositions and methods disclosed herein utilize antisense oligonucleotides that target long non-coding RNAs (lncRNAs) to increase FOXG1 expression in a cell, thereby restoring FOXG1 function.

Abstract: A pressure hose (1) for a water-carrying system is shown and described, especially for connecting sanitary taps or for connecting parts of the water-carrying system, having a corrugated inner hose (2) made of plastic, wherein at least one hose end (3, 5) of the pressure hose (1) is provided with a connecting piece (4, 6), designed such that it differs from the inner hose (2), for joining the pressure hose (1) to a complementarily designed connecting piece of a sanitary tap and/or a part of the water-carrying system. According to the invention, it is provided that the inner hose (2) and the connecting piece (4, 6) are formed as one piece and the inner hose (2) and the connecting piece (4, 6) are preferably produced via extrusion in a common extrusion process.

Abstract: A device for laser projection comprises a first laser diode configured to emit a first linearly polarized laser beam extending along a first polarization axis and a second laser diode configured to emit a second linearly polarized laser beam extending along a second polarization axis that is perpendicular to the first polarization axis. A polarization combiner is configured to combine the first and second linearly polarizing laser beams into a combined laser beam, wherein the combined laser beam comprises one of: (1) circular polarization; and (2) elliptical polarization. A measuring device is configured to measure an intensity of the combined laser beam. A control unit is configured to receive the measured intensity of the combined laser beam and is further configured to adjust an intensity of at least one of: (1) the first laser diode; and (2) the second laser diode.

Abstract: A plug-in tongue for a seatbelt includes a plug-in tongue component (10) and a clamping member (12) mounted thereto, wherein a belt guide passage (30) is delimited between the plug-in tongue component (10) and the clamping member (12), and the clamping member (12) comprises a center part (18) and two lateral parts (20) extending from the two ends of the center part (18) transversely to the latter. The plug-in tongue is characterized in that the center part (18) includes a central guide surface (32) located between the two lateral parts (20), and the two lateral parts (20) include lateral guide surfaces (34) facing each other, the guide surfaces (32, 34) constituting limitations of the belt guide passage (30).

Abstract: Methods and systems for training a model include training an encoder in an unsupervised fashion based on a backward latent flow between a reference frame and a driving frame taken from a same video. A diffusion model is trained that generates a video sequence responsive to an input image and a text condition, using the trained encoder to determine a latent flow sequence and occlusion map sequence of a labeled training video.

Abstract: A method for generating binding peptides presented by any given Major Histocompatibility Complex (MHC) protein is presented. The method includes, given a peptide and an MHC protein pair, enabling a Reinforcement Learning (RL) agent to interact with and exploit a peptide mutation environment by repeatedly mutating the peptide and observing an observation score of the peptide, learning to form a mutation policy, via a mutation policy network, to iteratively mutate amino acids of the peptide to obtain desired presentation scores, and generating, based on the desired presentation scores, qualified peptides and binding motifs of MHC Class I proteins.

Abstract: A method for generating binding peptides presented by any given Major Histocompatibility Complex (MHC) protein is presented. The method includes, given a peptide and an MHC protein pair, enabling a Reinforcement Learning (RL) agent to interact with and exploit a peptide mutation environment by repeatedly mutating the peptide and observing an observation score of the peptide, learning to form a mutation policy, via a mutation policy network, to iteratively mutate amino acids of the peptide to obtain desired presentation scores, and generating, based on the desired presentation scores, qualified peptides and binding motifs of MHC Class I proteins.