Abstract: A computer-implemented method is provided for generating new binding peptides to Major Histocompatibility Complex (MHC) proteins. The method includes training, by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data comprising the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data.

Abstract: A computer-implemented method is provided for generating new binding peptides to Major Histocompatibility Complex (MHC) proteins. The method includes training, by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data comprising the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data.

Abstract: A computer-implemented method is provided for generating new binding peptides to Major Histocompatibility Complex (MHC) proteins. The method includes training, by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data comprising the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data.

Abstract: A fastening assembly for fastening an axle support on a vehicle body. The axle support is screwed onto the vehicle body on multiple attachment points. On at least one of the attachment points, a bearing bracket for mounting a unit for the axle drive is arranged between the axle support and the vehicle body and also screwed on. A method for installing and fastening an axle support on a vehicle body in the mass production of motor vehicles is further disclosed.

Abstract: A helical gear transmission for an electromechanical servo steering mechanism may include a shaft that meshes with a helical gear. The shaft may be arranged in a transmission housing and, at its first end, may be mounted in a drive-side bearing arrangement so as to be rotatable about an axis of rotation. At its second end, the shaft may be mounted in a drive-remote bearing arrangement in the transmission housing. The drive-side bearing arrangement may have a rolling bearing, an outer ring of which is spherical. The rolling bearing may be enclosed by two bearing shells. The outer side of the outer ring may have two flat points that are opposite one another and form a pivot axis about which the shaft is pivotable in a direction of the helical gear.

Abstract: A multi-purpose detection circuit for object detection and vehicle position determination is described. For example, the circuit is configurable for detecting foreign metallic objects, living objects, and a vehicle or type of vehicle above an inductive wireless power transmitter. The circuit is also configurable for determining the vehicle's position relative to the inductive wireless power transmitter. An example apparatus includes a measurement circuit including a multiplexer, electrically connected to a plurality of inductive and capacitive sense circuits, for measuring one or more electrical characteristics in each of the inductive and capacitive sense circuits according to a predetermined time multiplexing scheme.

Abstract: A plant growth lighting system includes a plant support and a light guide luminaire module, the plant support being configured to hold one or more plants. The light guide luminaire module includes at least one light-emitting element (LEE), a light guide arranged to receive light emitted by the at least one LEE at a first end of the light guide and guide the received light in a forward direction to a second end thereof, and an extractor arranged to receive light from the second end of the light guide and configured to output light. The light guide luminaire module is disposed relative to the plant support such that at least a portion of the light output by the extractor impinges on the plants in predetermined directions.

Abstract: Disclosed are systems and methods of operation for capacitive radio frequency micro-electromechanical switches, such as CMUT cells for use in an ultrasound system. An RFMEMS may include substrate, a first electrode connected to the substrate, a membrane and a second electrode connected to the membrane. In some examples, there is a dielectric stack between the first electrode and the second electrode and flexible membrane. The dielectric stack design minimizes drift in the membrane collapse voltage. In other examples, one of the electrodes is in the form of a ring, and a third electrode is provided to occupy the space in the center of the ring. Alternatively, the first and second electrodes are both in the form of a ring and there is a support between the electrodes inside the rings.

Abstract: An integrally bladed rotor for a turbomachine, in particular a compressor or turbine stage of a gas turbine, to which at least one separately formed impulse element housing (40; 40?) is fastened by at least one fastening element (30; 30?) which engages for this purpose into an opening (41) of the impulse element housing and into an opening (11) of the rotor, the impulse element housing having at least one cavity (44) in which at least one impulse element (5) is accommodated with play.

Abstract: The invention relates to a test device (1) for testing the insulation of an electrical line (2), in particular a cable or a cable harness, for detecting error points in the insulation of the electrical line (2). The test device (1) comprises a scalable, evacuable chamber (3) for completely accommodating the electrical line (2) to be tested, wherein at least one electrical connection point (6), preferably in the form of a plug device part, for connecting the electrical line (2) to be tested is arranged inside the chamber (3) and an electrical feedthrough (7) leads from the connection point (6) out of the chamber (3).

Abstract: The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Abstract: An intraluminal ultrasound imaging device includes a flexible elongate member configured to be positioned within a body lumen of a patient. An ultrasound imaging assembly is disposed at the distal portion of the flexible elongate member. The ultrasound imaging assembly includes a plurality of acoustic elements and an acoustically-transparent window disposed over the plurality of acoustic elements. The acoustically-transparent window comprising a plurality of layers formed on top of one another. The plurality of layers includes an innermost layer directly contacting the plurality of acoustic elements, an outermost layer opposite the innermost layer, and an adhesive layer. The outermost layer includes a tubing. A hardness of the innermost layer is less than hardnesses of every other layer of the plurality of layers. A hardness of the outermost layer is greater than the hardnesses of every other layer of the plurality of layers.

Abstract: In a track part, in particular a low-alloy steel rail for rail vehicles, the steel comprises, in the rail head of the track part, a ferrite portion of 5-15 vol %, an austenite portion of 5-20 vol %, a martensite portion of 5-20 vol %, and a portion of carbide-free bainite of 55-75 vol %.

Abstract: A rotary control input device for a capacitive touch screen is disclosed. The control device comprises a mounting element for retaining the device in place on the capacitive touch screen, a circuit frame rotatably mounted on the mounting element, the circuit frame including a rotation electrode, the rotation electrode being disposed to be adjacent and spaced apart from the capacitive touch screen when the device is retained in place. The device further includes a conductive body portion that is electrically connected to the rotation electrode, the circuit frame being rotatable about the mounting element, with respect to the capacitive touch screen, by a user via the conductive body portion.

Abstract: The present disclosure relates to a device for visual field testing 11, which maps eye function of a test subject, the device comprising a display unit 17 displaying stimuli 23 to the test subject, and an eye tracking unit 19 detecting eye motions in response to the displayed stimuli. The display unit 17 displays at least a first 23 and a second 25 peripheral stimulus at different sectors in relation to a point of fixation 27 at the same time and the eye tracking unit determines which of the first and second stimulus is first gazed upon by the test subject. This allows different parts of the retina to compete with regards to retinal sensitivity and allows for a precise and efficient visual field testing.

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: A pressure hose (1) for a water-carrying system is shown and described, especially for connecting sanitary taps or for connecting parts of the water-carrying system, having a corrugated inner hose (2) made of plastic, wherein at least one hose end (3, 5) of the pressure hose (1) is provided with a connecting piece (4, 6), designed such that it differs from the inner hose (2), for joining the pressure hose (1) to a complementarily designed connecting piece of a sanitary tap and/or a part of the water-carrying system. According to the invention, it is provided that the inner hose (2) and the connecting piece (4, 6) are formed as one piece and the inner hose (2) and the connecting piece (4, 6) are preferably produced via extrusion in a common extrusion process.

Abstract: A narrow drive unit for a means of locomotion drivable simultaneously by drive energy provided by human muscular strength and by electric motors, comprising two harmonic gearings and two electric motors, wherein the sum of the drive energy provided by human muscular strength and the electric motors can be transmitted to an output shaft.

Abstract: A method of brake steering in a four-wheel drive utility vehicle having a driven front axle carrying at least two front wheels, a driven rear axle carrying at least two rear wheels, a powertrain delivering torque to the front and rear axles via a connecting shaft, independently operable service brakes on each of the front and rear wheels, and independently operable parking brakes on each of the rear wheels. The method includes, on the vehicle entering a turn, applying the service brakes of the front and rear wheels on the inside of the turn and applying also, and to a controllably varied level of braking force, the parking brake on the rear wheel on the inside of the turn.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.