Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.

Abstract: A method of manufacturing a semiconductor body includes forming a pattern at a first side of a substrate, forming a semiconductor layer on the first side of the substrate, attaching the substrate and the semiconductor layer to a carrier via a surface of the semiconductor layer, and removing the substrate from a second side opposite to the first side.

Abstract: Systems and methods are described for active harmonics cancellation. A wireless charging apparatus includes a wireless-power transfer circuit comprising a wireless-power transfer coil configured to generate or couple to a magnetic field to transfer or receive power and a plurality of tuning capacitors electrically coupled to the wireless-power transfer coil. The apparatus also includes a power converter circuit electrically coupled to the wireless-power transfer circuit. Additionally, the apparatus includes a signal generation circuit different from the power converter circuit and electrically coupled to one or more nodes between capacitors of the plurality of tuning capacitors. The signal generation circuit is configured to generate and inject a signal into the wireless-power transfer circuit at the nodes between the capacitors. The signal generation circuit includes a rejection filter tuned to an operating frequency of the wireless-power transfer coil.

Abstract: An electronic circuit breaker comprising: an input connected to an electric DC power supply; an output connected to a load; the input connected to the output via a switch, said switch is controlled via a switch control line between an “ON”-state and an “OFF”-state; a switch driver connected to the switch control line, said switch driver configured to control the switch; and a switch protection, a voltage detection branch configured to output a first electric potential indicative of the electrical potential difference between the input and the output; a comparator circuit configured to compare the first electrical potential with a first threshold voltage, said first threshold voltage is indicative of an over-current level flowing through the switch; and a gate controller connected to the switch disable line and configured to disable the switch by connecting the switch control line to a potential which causes the switch to enter the “OFF”-state.

Abstract: Moiré is an appealing visual effect observable when two or more repetitive patterns are superposed. We introduce a method for designing and fabricating level-line moirés on curved surfaces. These moiré shapes are obtained by superposing a partly absorbing or partly light deviating curved base layer and a curved revealing layer formed by a grating of transparent lines or cylindrical lenses. The distances between base layer and revealing layer are adapted to the locally varying distances between successive transparent lines or cylindrical lenses of the curved revealing layer grating. We demonstrate the quality of our method by rendered simulations and by fabrication. The resulting level-line moiré display devices can be manufactured using different fabrication techniques, from multi-material 3D printing to molding.

Abstract: An electrical machine, in particular an electronically commutated machine, includes a housing and a controller accommodated in the housing. The controller is configured to drive the machine to generate a magnetic rotating field. The housing has a housing cup, which surrounds a hollow space, and a housing cover. The machine has an end plate accommodated in the housing cup. The end plate is thermally conductively connected to the housing cup. The machine also has a cooling panel thermally conductively connected to the housing cup and to at least one component, or to a plurality of components, of the control unit. The machine has an inverter comprising semiconductor switches. The semiconductor switches are thermally conductively connected to the end plate. The end plate and the cooling panel enclose a portion of the hollow space.

Abstract: Methods for identifying a patient who is eligible for an intensification of heart failure therapy are disclosed. Furthermore, methods for optimizing B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy are disclosed. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described methods.

Abstract: A control circuit may be configured to control light emitting diode (LED) driver circuits. The control circuit may be configured to generate a multicast of pixel intensity values based on data in memory or data received from a data source, and output the multicast on an interface, which may comprise a one-wire uni-directional interface. In some examples, a plurality of drivers may receive the multicast, and each of the plurality of drivers may drive different sets of LEDs based on the multicast.

Abstract: A connection assembly for connecting a tool head and a further machine module of a machine tool, in particular a surface finishing machine, wherein the connection assembly (10) includes at least two connection parts following one another along a longitudinal axis and each having a connection section via which the connection parts are connectable to one another.

Abstract: An insect trap device and methods of using the device are described herein. In some embodiments, an insect trap includes a light source, a removable enclosure with at least one opening, an adhesive surface at least partially within the enclosure, and optics to redirect light from the light source onto an adhesive trapping surface. The light source may include at least one light emitting diode (LED). The optics may be attached to the removable enclosure, and may be located at least partially within the enclosure. The optics may include optical enhancers such as a reflector, a lens and/or a diffuser. The insect trap may further include an insect attractant that emits sound or scent.

Abstract: The present disclosure relates to a method and a corresponding device (1) for providing an eye metric. The device comprises a display unit (3), producing a visual stimulus (7) to an eye, a feedback unit (9) measuring a response to the stimulus, and an analysing unit (11), outputting a metric result. The device is configured to produce a recurring bleaching impulse together with the stimulus wherein the bleaching impulse is repeated with a frequency greater than 0.3 Hz. This serves to keep the cones of the eye's retina in a saturated state, and the produced metric may be useful in apparatuses for eye evaluation.

Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: A spectacle lens for a spectacle frame having a first spectacle lens area and a second spectacle lens area. The first spectacle lens area is more strongly colored than the second spectacle lens area. The spectacle lens is phototropic at least in the second spectacle lens area.

Abstract: A belt shaft housing (40) for a belt shaft of a seatbelt system comprises a shaft holder (42) for holding the belt shaft, a securing component (48) including a retaining portion (88), and at least one fixing element (74) that is configured to fasten the belt shaft within the shaft holder (42). The securing component (48) is fastened to the shaft holder (42) such that it can adopt an assembly position and a securing position, wherein the fixing element (74) is released in the assembly position and is secured to the shaft holder (42) in the securing position. Further, a belt shaft including a webbing, a belt pin and a sleeve-shaped axle is provided. There is moreover provided a belt tensioner, especially an end fitting tensioner, comprising such belt shaft housing (40) and such belt shaft as well as a method for assembling such belt tensioner.

Abstract: The present invention provides materials and methods for determining optimal dosage regimens for therapeutic agents. In particular, the invention relates to dosage regimens for therapeutic agents capable of targeting IL-2 receptor, preferably interleukin 2 (IL2)-based therapeutic agents. The methods of the invention allow general dosage regimens to be determined for new IL-2R targeted therapeutic agents but also specifically tailored dosage regimens to be achieved for individuals being treated with IL-2R targeted therapeutic agents.

Abstract: A device for generating a photometric stereo image and a color image of an object which is moved at a predetermined relative speed relative to the device. The device includes a lighting area and a lighting arrangement which is oriented to the lighting area. The lighting arrangement cyclically emits a lighting sequence in the lighting area. The lighting sequence has at least four lighting pulses each of which have a wavelength range and a lighting direction. At least three of the at least four lighting pulses have a different wavelength range, and at least two of the at least four lighting pulses have a different lighting direction and a same wavelength range.

Abstract: The invention provides nanobodies that bind with high affinity to SARS-CoV-2 non-structural protein (Nsp), as well and compositions comprising the identified nanobodies and methods of use thereof to block activation of SARS-CoV-2 viral replication, and for the treatment or prevention of COVID-19.

Abstract: The invention relates to a sealed bag containing a reference fluid for the calibration or quality control of a sensor element for measuring body fluid parameters, the bag comprising peripheral walls of a first layered material. The bag further comprises an access port formed by an opening in the first layered material, wherein the opening is sealed by a cover of a second layered material, wherein the second layered material is more resistant to oxidation by the reference fluid than the first layered material.

Abstract: A computer-implemented method for simulating particle impacts in a gas path of an aircraft engine, the method including i) providing a structural-mechanical model of at least one section of the gas path, the model including structurally or mechanically modeled airfoils, ii) placing a particle at a position in the gas path of the model, iii) moving the particle with a velocity vector that was previously determined in a computational fluid dynamics (CFD) simulation in a CFD model of the at least one section of the gas path for a fluid flowing through the gas path, and iv) detecting an impact when the moving particle hits a component of the structural-mechanical model.