Abstract: The present invention relates to novel high-value polycarbonate polyols, to processes for the production thereof, to polyisocyanate prepolymers obtainable therefrom and also polyurethane (PUR) and polyurethane urea elastomers which under particularly demanding applications show unique combinations of processing characteristics, hydrolysis and oxidation stability, mechanical and dynamic mechanical properties.

Abstract: A computer-implemented method for learning disentangled representations for T-cell receptors to improve immunotherapy is provided. The method includes optionally introducing a minimal number of mutations to a T-cell receptor (TCR) sequence to enable the TCR sequence to bind to a peptide, using a disentangled Wasserstein autoencoder to separate an embedding space of the TCR sequence into functional embeddings and structural embeddings, feeding the functional embeddings and the structural embeddings to a long short-term memory (LSTM) or transformer decoder, using an auxiliary classifier to predict a probability of a positive binding label from the functional embeddings and the peptide, and generating new TCR sequences with enhanced binding affinity for immunotherapy to target a particular virus or tumor.

Abstract: A multi-purpose detection circuit for object detection and vehicle position determination is described. For example, the circuit is configurable for detecting foreign metallic objects, living objects, and a vehicle or type of vehicle above an inductive wireless power transmitter. The circuit is also configurable for determining the vehicle's position relative to the inductive wireless power transmitter. An example apparatus includes a measurement circuit including a multiplexer, electrically connected to a plurality of inductive and capacitive sense circuits, for measuring one or more electrical characteristics in each of the inductive and capacitive sense circuits according to a predetermined time multiplexing scheme.

Abstract: An inspection arrangement for fluorescence-based inspection of a product containing at least one fluorophore having an excitation spectrum and an emission spectrum, the inspection arrangement including a radiation source for generating a first electromagnetic radiation in a first wavelength range containing an excitation spectrum and a second electromagnetic radiation in a second wavelength range containing the emission spectrum, an imaging device for generating images of an inspection area in which the product can be arranged, and an image data processing device for image processing of the images. The inspection arrangement captures with the imaging device at least one fluorescence image of the inspection area irradiated with the first electromagnetic radiation and at least one reference image of the inspection area irradiated with the second electromagnetic radiation.

Abstract: A method for generating binding peptides presented by any given Major Histocompatibility Complex (MHC) protein is presented. The method includes, given a peptide and an MHC protein pair, enabling a Reinforcement Learning (RL) agent to interact with and exploit a peptide mutation environment by repeatedly mutating the peptide and observing an observation score of the peptide, learning to form a mutation policy, via a mutation policy network, to iteratively mutate amino acids of the peptide to obtain desired presentation scores, and generating, based on the desired presentation scores, qualified peptides and binding motifs of MHC Class I proteins.

Abstract: A system for binding peptide search for immunotherapy is presented. The system includes employing a deep neural network to predict a peptide presentation given Major Histocompatibility Complex allele sequences and peptide sequences, training a Variational Autoencoder (VAE) to reconstruct peptides by converting the peptide sequences into continuous embedding vectors, running a Monte Carlo Tree Search to generate a first set of positive peptide vaccine candidates, running a Bayesian Optimization search with the trained VAE and a Backpropagation search with the trained VAE to generate a second set of positive peptide vaccine candidates, using a sampling from a Position Weight Matrix (sPWM) to generate a third set of positive peptide vaccine candidates, screening and merging the first, second, and third sets of positive peptide vaccine candidates, and outputting qualified peptides for immunotherapy from the screened and merged sets of positive peptide vaccine candidates.

Abstract: A system for binding peptide search for immunotherapy is presented. The system includes employing a deep neural network to predict a peptide presentation given Major Histocompatibility Complex allele sequences and peptide sequences, training a Variational Autoencoder (VAE) to reconstruct peptides by converting the peptide sequences into continuous embedding vectors, running a Monte Carlo Tree Search to generate a first set of positive peptide vaccine candidates, running a Bayesian Optimization search with the trained VAE and a Backpropagation search with the trained VAE to generate a second set of positive peptide vaccine candidates, using a sampling from a Position Weight Matrix (sPWM) to generate a third set of positive peptide vaccine candidates, screening and merging the first, second, and third sets of positive peptide vaccine candidates, and outputting qualified peptides for immunotherapy from the screened and merged sets of positive peptide vaccine candidates.

Abstract: A system for binding peptide search for immunotherapy is presented. The system includes employing a deep neural network to predict a peptide presentation given Major Histocompatibility Complex allele sequences and peptide sequences, training a Variational Autoencoder (VAE) to reconstruct peptides by converting the peptide sequences into continuous embedding vectors, running a Monte Carlo Tree Search to generate a first set of positive peptide vaccine candidates, running a Bayesian Optimization search with the trained VAE and a Backpropagation search with the trained VAE to generate a second set of positive peptide vaccine candidates, using a sampling from a Position Weight Matrix (sPWM) to generate a third set of positive peptide vaccine candidates, screening and merging the first, second, and third sets of positive peptide vaccine candidates, and outputting qualified peptides for immunotherapy from the screened and merged sets of positive peptide vaccine candidates.

Abstract: A multi-purpose detection circuit for object detection and vehicle position determination is described. For example, the circuit is configurable for detecting foreign metallic objects, living objects, and a vehicle or type of vehicle above an inductive wireless power transmitter. The circuit is also configurable for determining the vehicle's position relative to the inductive wireless power transmitter. An example apparatus includes a measurement circuit including a multiplexer, electrically connected to a plurality of inductive and capacitive sense circuits, for measuring one or more electrical characteristics in each of the inductive and capacitive sense circuits according to a predetermined time multiplexing scheme.

Abstract: An insect trap device and methods of using the device are described herein. In some embodiments, an insect trap includes a light source, a removable enclosure with at least one opening, an adhesive surface at least partially within the enclosure, and optics to redirect light from the light source onto an adhesive trapping surface. The light source may include at least one light emitting diode (LED). The optics may be attached to the removable enclosure, and may be located at least partially within the enclosure. The optics may include optical enhancers such as a reflector, a lens and/or a diffuser. The insect trap may further include an insect attractant that emits sound or scent.

Abstract: A method for manufacturing a magnetic field sensor chip with an integrated back-bias magnet is described. A substrate with a first substrate surface and an opposite second substrate surface is provided, wherein at least one magnetic field sensor is arranged in a first substrate surface. A cavity is structured into the second substrate surface. The method involves generating the integrated back-bias magnet within the first cavity by introducing loose powder comprising a magnetic material into the first cavity and agglomerating the powder to a mechanically firm magnetic body structure by means of atomic layer deposition. According to the method, the step of generating the back-bias magnet is carried out temporally after the step of arranging the magnetic field sensor.

Abstract: An arrangement reduces oscillation (vibration) of an oscillatory structure. The arrangement has a structure having at least one mode in at least one direction; and an oscillation-reducing device (vibration-reducing device). The oscillation-reducing devices has a housing formed by or provided on the structure, a cavity, and a body configured for making impact contacts with the housing and disposed in the cavity in such a manner that the body is configured to make impact contacts with the housing at least temporarily for as long as the structure is excited in the at least one mode in the at least on direction.

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

Abstract: The disclosure relates to methods for a communication between a sensor and a satellite, and sensors for carrying out such a method. The sensor has a transmission unit for transmitting sensor data from the sensor to the satellite and a computing unit for calculating the position of the satellite at a specified point in time. The satellite is configured to receive and forward the sensor data. The method includes calculating a coverage duration using path parameters of the satellite and the position of the sensor, activating the transmission unit of the sensor during a transmission duration based on the calculated coverage duration, and transmitting the sensor data from the sensor to the satellite during the transmission duration.

Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.

Abstract: Methods and systems for disentangled data generation include accessing a dataset including pairs, each formed from a given input text structure and a given style label for the input text structures. An encoder is trained to disentangle a sequential text input into disentangled representations, including a content embedding and a style embedding, based on a subset of the dataset, using an objective function that includes a regularization term that minimizes mutual information between the content embedding and the style embedding. A generator is trained to generate a text output that includes content from the style embedding, expressed in a style other than that represented by the style embedding of the text input.

Abstract: In a computer-implemented method for setting a field of view for a magnetic resonance scan, exclusion information describing a region of the original field of view that is unmapped owing to the distortion is ascertained on the basis of the distortion map for at least one first set of field-of-view parameters describing a rectangular or cuboidal original field of view, the exclusion information is used to determine a second set of field-of-view parameters to be used for the magnetic resonance scan, and the magnetic resonance scan is performed using the second set of field-of-view parameters.

Abstract: A pot-shaped composite brake rotor for motor vehicles, which combines at least one securing component as a hub interface with at least one friction ring component (as a friction partner for at least one friction lining. Distinction is made between a torque transmission function a fixing function between the paired components by the provision of a heat-conductive joint interface between the components on one side. The components are assembled coaxially with one another and joined rotationally fixedly in the axial direction so that the securing component serves as a heat sink for the friction ring component. At least one fixing element between the components is provided separately, and this fixing element substantially exclusively (nominal load) performs a fixing function by mutual form fit by a radially directed engagement behind at least one undercut. A press-fit connection s present for torque transmission between the securing component and the friction ring component.

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically co