Patents by Inventor Hirofumi Nakano

Hirofumi Nakano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5366879
    Abstract: Disclosed is a method of producing a branched cyclodextrin where a liquid containing a cyclodextrin and a branched oligosaccharide is treated with a debranching enzyme. By the method, a branched cyclodextrin having a maltosyl or maltotriosyl group as bonded to the glucose of a CD molecule via an .alpha.-1,6 bond is obtained efficiently.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: November 22, 1994
    Assignees: Ensuiko Sugar Refining Co., Ltd., Sumio Kitahata, Hirofumi Nakano
    Inventors: Sumio Kitahata, Koji Hara, Koki Fujita, Nobuhiro Kuwahara, Hirofumi Nakano
  • Patent number: 5308659
    Abstract: A method of molten metal plating, comprising the steps of: bringing a travelling steel strip into contact with a revolving roll; applying a molten metal on the roll through a nozzle disposed near the roll; and transferring the applied molten metal from the roll to the steel strip by the revolution of the roll. An apparatus for molten metal plating, comprising: a coating roll capable of being brought into contact with a travelling steel strip; a nozzle disposed near said roll for applying a molten metal on said roll; and means for supplying a molten metal to said nozzle.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: May 3, 1994
    Assignee: Nippon Steel Corporation
    Inventors: Yashichi Oyagi, Hirofumi Nakano
  • Patent number: 5260169
    Abstract: A method for manufacturing a semiconductor device having a via hole penetrating a semiconductor substrate and electrically and thermally connecting an electrode of an element disposed on a front surface of the substrate to a metal layer disposed on a back surface of the substrate includes forming on the front surface of the substrate a metal pattern having an opening at a region where the via hole is to be formed and connected to a part of the electrode of the element, forming a hole, and forming a metal film connected to the metal pattern on the inside surface of the hole. The metal pattern can be formed using a positive resist on a flat substrate whereby a highly precise pattern is obtained.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: November 9, 1993
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventor: Hirofumi Nakano
  • Patent number: 5189187
    Abstract: A clerodane-type diterpene derivative, which has antibacterial and antitumor activities, as well as chemically equivalent tautomers thereof and a process for producing said derivative using a microorganism belonging to the genus Streptomyces.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: February 23, 1993
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Shozo Kawada, Yoichi Uosaki, Yutaka Saito, Katsushige Gomi, Toshiaki Iwazaki
  • Patent number: 5151352
    Abstract: A clerodane-type diterpene derivative, which has antibacterial and antitumor activities, as well as chemically equivalent tautomers thereof and a process for producing said derivative using a microorganism belonging to the genus Streptomyces.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: September 29, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Shozo Kawada, Yoichi Uosaki, Yutaka Saito, Katsushige Gomi, Toshiaki Iwazaki
  • Patent number: 5135375
    Abstract: An apparatus for packing a permanent magnet powder wherein a solenoid coil is provided near the opening of a cylindrical molding space of a mold in such a manner that the direction of the central axis of the solenoid coil substantially coincides with the central axis of the molding space, and an alternating current magnetic field is applied, so that a permanent magnet powder above the opening is packed into the molding space. A magnetic pole may be provided in the center of the solenoid coil. The method of the present invention can be applied to not only a powder for a sintered magnet and cast magnet, but also a powder for a bonded magnet.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: August 4, 1992
    Assignee: Fuji Electrochemical Co., Ltd.
    Inventors: Yoshio Matsuo, Hirofumi Nakano, Masakuni Kamiya, Kazuo Matsui
  • Patent number: 5106868
    Abstract: Compounds UCF1 and derivatives thereof exhibit anti-bacterial and anti-tumor activities and may be used for the preparation of anti-bacterial and anti-tumor agents.Compounds UCF1 may be produced by fermentation of a microorganism of the genus Streptomyces capable of producing compounds UCF1, preferably Streptomyces sp. UOF1 (FERM BP-2844) and recovering the desired compounds from the cultured broth.The compounds UCF1 have the formula ##STR1## wherein R represents either ##STR2## The compounds may be oxidized to obtain derivatives of formula ##STR3## which exhibit similar pharmacological activities.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: April 21, 1992
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Yutaka Saito, Yoji Ikuina, Toshimitsu Takiguchi, Masami Okabe
  • Patent number: 5101038
    Abstract: A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: March 31, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Isami Takahashi, Isao Kawamoto, Toru Yasuzawa, Keiichi Takahashi, Eiji Kobayashi
  • Patent number: 5082857
    Abstract: The present invention relates to a compound designated "DC114-C" having excellent anti-bacterial and anti-tumor activities. This compound may be obtained by fermentation of a microorganism of the genus Streptomyces, preferably Streptomyces sp. DO-114 (FERM BP-2641).
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: January 21, 1992
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Yohichi Uosaki, Isao Kawamoto, Keiiechi Takahashi, Katsushige Gomi
  • Patent number: 5079376
    Abstract: Disclosed is novel compound UCT-1003 represented by the following formula: ##STR1## and having anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces.
    Type: Grant
    Filed: January 23, 1990
    Date of Patent: January 7, 1992
    Assignee: Kyowa Hakko Kogyo, Ltd.
    Inventors: Hirofumi Nakano, Yoshinori Yamashita, Katsuhiko Ando, Yutaka Saito, Keiichi Takahashi, Hiroe Ohno
  • Patent number: 5066817
    Abstract: Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: November 19, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Tsuyoshi Mokudai, Isao Kawamoto, Mayumi Yoshida, Eiji Kobayashi
  • Patent number: 5004580
    Abstract: A method and apparatus for packing a permanent magnet powder wherein a solenoid coil is provided near the opening of a cylindrical molding space of a mold in such a manner that the direction of the central axis of the solenoid coil substantially coincides with the central axis of the molding space, and an alternating current magnetic field is applied, so that a permanent magnet powder above the opening is packed into the molding space. A magnetic pole may be provided in the center of the solenoid coil. The method of the present invention can be applied to not only a powder for a sintered magnet but also a powder for a bonded magnet.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: April 2, 1991
    Assignee: Fuji Electrochemical Co. Ltd.
    Inventors: Yoshio Matsuo, Hirofumi Nakano, Masakuni Kamiya, Kezuo Matsui
  • Patent number: 4999196
    Abstract: A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: March 12, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Isami Takahashi, Kozo Asano, Takao Iida, Makoto Morimoto
  • Patent number: 4992570
    Abstract: UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.
    Type: Grant
    Filed: March 24, 1988
    Date of Patent: February 12, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Eiji Kobayashi, Isami Takahashi, Katsuhiko Ando, Mayumi Yoshida, Shiro Akinaga, Takao Iida
  • Patent number: 4952576
    Abstract: Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: August 28, 1990
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Toru Yasuzawa, Hiroshi Sano, Hirofumi Nakano, Shunji Ichikawa, Katsuichi Shuto
  • Patent number: 4935415
    Abstract: UCN-01 having an anti-tumor activity and an anti-bacterial activity is produced by culturing a microorganism belonging to the genus Streptomyces.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: June 19, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Isami Takahashi, Tatsuya Tamaoki, Fusao Tomita, Isao Kawamoto, Kozo Asano, Makoto Morimoto, Hisayo Nomoto
  • Patent number: 4923990
    Abstract: The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: May 8, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Isami Takahashi, Michio Ichimura, Isao Kawamoto, Kozo Asasno, Fusao Tomita, Hiroshi Sano, Toru Yasuzawa, Makoto Morimoto, Kazuhisa Fujimoto
  • Patent number: 4914198
    Abstract: Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: April 3, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Yoshinori Yamashita, Isao Kawamoto, Katsuhiko Ando, Hiroshi Sano, Toru Yasuzawa, Katsuichi Shuto
  • Patent number: 4902646
    Abstract: A production method for a semiconductor device (e.g. MESFET) includes a metal pattern production process for producing a plurality of metal patterns e.g. gate, source, drain electrodes on a semiconductor substrate having an active layer. The metal pattern production process includes disposing dummy metal patterns (2a/2b) of silicon nitride at a plurality of metal pattern production regions on the semiconductor substrate using a resist mask (3), disposing a resist pattern (4) on the entire surface of the substrate with gaps between the metal pattern production regions, filling the gaps between said dummy metal patterns and the resist pattern with resist by reflowing the resist pattern (4), removing the dummy metal patterns (2a), depositing a metal layer over the entire surface of the partially completed device, and lifting off unwanted metal to produce a desired metal pattern of source/drain electrodes (5).
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: February 20, 1990
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventor: Hirofumi Nakano
  • Patent number: 4871419
    Abstract: A first metal film is formed on the major surface of a semiconductor substrate and a thin film which is at least equal in thickness to a second metal film is formed on the first metal film. These films are patterned to provide a two-layer film pattern of a prescribed configuration, and a resist film is coated on the major surface of the semiconductor substrate including the two-layer film pattern. The surface of the resist film is partially removed to expose a thin film pattern serving as an upper layer of the two-layer film pattern, and only the thin film pattern is removed. A second metal film is evaporated over the entire surface of the resist film including the first metal film pattern exposed in the preceding step and thereafter the resist film is removed with the second metal film formed on the same, to form the two-layer metal film pattern by the first metal film pattern and the second metal film pattern.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: October 3, 1989
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventor: Hirofumi Nakano