Patents by Inventor Hitesh Batra

Hitesh Batra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of treprostinil
    Patent number: 12357599
    Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
    Type: Grant
    Filed: October 17, 2023
    Date of Patent: July 15, 2025
    Assignees: United Therapeutics Corporation, MannKind Corporation
    Inventors: Hitesh Batra, Liang Guo, Patrick Poisson, Sri Harsha Tummala, Elizabeth Ann Harris
  • SYNTHESES OF COMPOUNDS USEFUL FOR PRODUCING TREPROSTINIL
    Publication number: 20250197338
    Abstract: Provided are methods of producing compounds, which are useful in synthesizing prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: November 8, 2024
    Publication date: June 19, 2025
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sri Harsha Tummala, Mark Farquharson
  • TREPROSTINIL PRODRUGS
    Publication number: 20250154181
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: December 23, 2024
    Publication date: May 15, 2025
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
    Publication number: 20250064743
    Abstract: Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl dikctopiperazinc.
    Type: Application
    Filed: November 4, 2024
    Publication date: February 27, 2025
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo, Patrick Poisson, Susovan Jana
  • SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
    Publication number: 20250002442
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: September 16, 2024
    Publication date: January 2, 2025
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Treprostinil prodrugs
    Patent number: 12173021
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Grant
    Filed: March 10, 2023
    Date of Patent: December 24, 2024
    Assignee: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • Treprostinil derivatives and their use in pharmaceutical compositions
    Patent number: 12168071
    Abstract: Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl diketopiperazine.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: December 17, 2024
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo, Patrick Poisson, Susovan Jana
  • Synthesis of esuberaprost prodrugs
    Patent number: 12162853
    Abstract: Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: December 10, 2024
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • SALTS OF TREPROSTINIL
    Publication number: 20240400487
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: April 15, 2024
    Publication date: December 5, 2024
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • TREPROSTINIL ANALOGS AND RELATED METHODS OF MAKING AND USING
    Publication number: 20240287105
    Abstract: Provided are novel treprostinil derivatives, including treprostinil prodrugs and treprostinil analogs, as well as methods of making and using these compounds.
    Type: Application
    Filed: January 18, 2024
    Publication date: August 29, 2024
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan Tuladhar, Sri Harsha Tummala, Yousheng Guan, Mark Farquharson
  • SALTS OF TREPROSTINIL
    Publication number: 20240262778
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 8, 2024
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • STABLE TREPROSTINIL PRODRUGS
    Publication number: 20240130989
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: November 27, 2023
    Publication date: April 25, 2024
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • PRODRUGS OF TREPROSTINIL
    Publication number: 20240058287
    Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
    Type: Application
    Filed: October 17, 2023
    Publication date: February 22, 2024
    Applicants: United Therapeutics Corporation, MannKind Corporation
    Inventors: Hitesh BATRA, Liang GUO, Patrick POISSON, Sri Harsha TUMMALA, Elizabeth Ann HARRIS
  • TREPROSTINIL PRODRUGS
    Publication number: 20240051979
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 15, 2024
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • RALINEPAG PRODRUGS AND USES THEREOF
    Publication number: 20240002334
    Abstract: Described herein are ralinepag prodrugs, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound, such as but not limited to pulmonary hypertension (PH) diseases.
    Type: Application
    Filed: March 17, 2023
    Publication date: January 4, 2024
    Inventors: Hitesh BATRA, Patrick POISSON, Liang GUO, Susovan JANA, Sri Harsha TUMMALA
  • Stable treprostinil prodrugs
    Patent number: 11826328
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: November 28, 2023
    Assignee: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20230338313
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: June 28, 2023
    Publication date: October 26, 2023
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • Prodrugs of treprosiinil
    Patent number: 11793780
    Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: October 24, 2023
    Assignees: United Therapeutics Corporation, Mann Kind Corporation
    Inventors: Hitesh Batra, Liang Guo, Patrick Poisson, Sri Harsha Tummala, Elizabeth Ann Harris
  • TREPROSTINIL PRODRUGS
    Publication number: 20230255922
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 17, 2023
    Applicant: United Therapeutics Corporation
    Inventors: Ken PHARES, Hitesh BATRA, Liang GUO, Adam Marc SILVERSTEIN
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 11723887
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: August 15, 2023
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh