Patents by Inventor Hitesh Batra

Hitesh Batra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of esuberaprost prodrugs
    Patent number: 11560363
    Abstract: Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: January 24, 2023
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • STABLE TREPROSTINIL PRODRUGS
    Publication number: 20220323387
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: December 13, 2021
    Publication date: October 13, 2022
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
    Publication number: 20220280430
    Abstract: Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl diketopiperazine.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 8, 2022
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo, Patrick Poisson, Susovan Jana
  • SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
    Publication number: 20220213020
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: January 17, 2022
    Publication date: July 7, 2022
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • SALTS OF TREPROSTINIL
    Publication number: 20220153675
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • Salts of treprostinil
    Patent number: 11236035
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 1, 2022
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
  • Synthesis of intermediates for producing prostacyclin derivatives
    Patent number: 11225452
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin. The methods include heating the compound of Formula 2 at a temperature of 180° C. to 185° C. Wherein the heating comprises irradiating the compound of formula 2 with microwave radiation.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: January 18, 2022
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • PRODRUGS OF TREPROSTINIL
    Publication number: 20210378996
    Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Applicants: United Therapeutics Corporation, MannKind Corporation
    Inventors: Hitesh BATRA, Liang GUO, Patrick POISSON, Sri Harsha TUMMALA, Elizabeth Ann HARRIS
  • SYNTHESIS OF ESUBERAPROST PRODRUGS
    Publication number: 20210355095
    Abstract: Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: October 17, 2019
    Publication date: November 18, 2021
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Liang GUO
  • SALTS OF TREPROSTINIL
    Publication number: 20210179528
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: November 30, 2020
    Publication date: June 17, 2021
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • TREPROSTINIL PRODRUGS
    Publication number: 20210121433
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: January 4, 2021
    Publication date: April 29, 2021
    Applicant: United Therapeutics Corporation
    Inventors: Ken PHARES, Hitesh BATRA, Liang GUO, Adam Marc SILVERSTEIN
  • TREPROSTINIL PRODRUGS
    Publication number: 20210054009
    Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
    Type: Application
    Filed: August 24, 2020
    Publication date: February 25, 2021
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Robert Phares, Hitesh Batra, Liang Guo
  • SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
    Publication number: 20200369592
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Synthesis of intermediates for producing prostacyclin derivatives
    Patent number: 10774027
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 15, 2020
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Method of producing beraprost
    Patent number: 10710973
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: July 14, 2020
    Assignee: Lung Biotechnology PBC
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Methods for producing Beraprost and its derivatives
    Patent number: 10640481
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 5, 2020
    Assignee: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 10548863
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 4, 2020
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20200030271
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: October 7, 2019
    Publication date: January 30, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 10478410
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 19, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • SALTS OF TREPROSTINIL
    Publication number: 20190256449
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang