Patents by Inventor Hitesh Batra

Hitesh Batra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9593066
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: March 14, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Patent number: 9593061
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: March 14, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20170044126
    Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
    Type: Application
    Filed: August 11, 2016
    Publication date: February 16, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • Publication number: 20160244422
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 25, 2016
    Applicant: Lung Biotechnology PBC
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Publication number: 20160221993
    Abstract: The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The present inventors discovered certain deoxynojirimycin derivatives may be effective against one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition caused by or associated with one or more viruses. In certain embodiments, the deoxynojirimycin derivatives may increase a survival rate or probability for a subject infected with one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus.
    Type: Application
    Filed: September 15, 2014
    Publication date: August 4, 2016
    Applicant: Emergent Virology LLC
    Inventors: Urban RAMSTEDT, Raju PENMASTA, Hitesh BATRA, Tam NGUYEN
  • Patent number: 9334255
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: May 10, 2016
    Assignee: Lung Biotechnology PBC
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Publication number: 20160107973
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: October 19, 2015
    Publication date: April 21, 2016
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20150376106
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: September 10, 2015
    Publication date: December 31, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • Patent number: 9181212
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analog compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: November 10, 2015
    Assignee: Lung Biotechnology PBC
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Publication number: 20150299091
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Patent number: 9156786
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: October 13, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Publication number: 20150266801
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 24, 2015
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • Patent number: 9102660
    Abstract: A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: August 11, 2015
    Assignee: United Therapeutics Corporaiton
    Inventors: Hitesh Batra, Liang Guo
  • Publication number: 20150183757
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: March 12, 2015
    Publication date: July 2, 2015
    Applicant: Lung Biotechnology Inc.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Patent number: 9050311
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: June 9, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola, Hitesh Batra
  • Publication number: 20150105582
    Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
  • Patent number: 8940930
    Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 27, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20140288314
    Abstract: A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 25, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • Publication number: 20140275616
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
  • Publication number: 20140275573
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 18, 2014
    Applicant: LUNG BIOTECHNOLOGY INC.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar