Patents by Inventor Hitoshi Shimizu

Hitoshi Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D derivatives
    Patent number: 7074777
    Abstract: The object of the present invention is to provide a vitamin D derivative exhibiting excellent physiological activity as medicines, in particular as therapeutic agents for skin disease including psoriasis, and having decreased hypercalcemic activity. The present invention provides vitamin D derivatives represented by the general Formula (1): wherein in Formula (1), X is oxygen or sulfur; R1 is hydrogen or Formula (2) R2 is hydrogen or alkyl; R3 and R4 are hydrogen or alkyl or R3 and R4 together form a double bond between the 16- and 17-positions; R5 is hydrogen or —OR13 in which R13 is hydrogen or a protecting group; and R6 is hydrogen or a protecting group.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: July 11, 2006
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Akira Kawase, Hitoshi Shimizu, Kazuki Shimizu, Takashi Emura, Kazutomo Kinoshita
  • Apparatus and method of assay in utilizing attenuated total reflection
    Publication number: 20060119852
    Abstract: A surface plasmon resonance (SPR) assay apparatus is loaded with a sensor unit. The sensor unit has a sensing surface and a flow channel, which has an entrance end opening and an exit end opening, and causes analyte fluid introduced through the entrance end opening to flow on the sensing surface. An optical assay unit assays reaction of the analyte fluid on the sensing surface by detecting attenuation of the illuminated light reflected by a thin film/dielectric interface. A fluid dispenser introduces the analyte fluid to the entrance end opening by pipetting. A fluid collecting vessel stores the analyte fluid used and exited from the exit end opening. A drain conduit extends from the exit end opening toward the fluid collecting vessel, for passage of the used analyte fluid. A suction pump drains the used analyte fluid into the fluid collecting vessel through the drain conduit.
    Type: Application
    Filed: September 30, 2005
    Publication date: June 8, 2006
    Inventor: Hitoshi Shimizu
  • Measuring apparatus and measuring chip
    Patent number: 7030988
    Abstract: Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: April 18, 2006
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Takashi Kubo, Katsuaki Muraishi, Toshihito Kimura, Hitoshi Shimizu, Nobufumi Mori
  • Sample supplying method and device
    Publication number: 20060073609
    Abstract: An inlet pipette tip, into which a sample has been sucked, is fitted to an inlet of a flow path member of an analysis unit comprising a dielectric material block having a smooth surface, on which a thin film layer has been formed, and the flow path member, which is brought into close contact with a top surface of the thin film layer. An outlet pipette tip is fitted to an outlet of the flow path member. The sample is delivered from the inlet pipette tip through the inlet of the flow path member into a flow path of the flow path member. A fluid, which has been expelled by the sample from the flow path to the outlet of the flow path member, is recovered into the outlet pipette tip.
    Type: Application
    Filed: October 4, 2005
    Publication date: April 6, 2006
    Inventor: Hitoshi Shimizu
  • Rear projector for projecting an image from a rear side of a screen
    Patent number: 7021769
    Abstract: A light-source unit is disposed such that illumination light is horizontally emitted relative to an oblong screen. Three liquid-crystal display panels respectively have a liquid-crystal display surface of a rectangle. The display panels are disposed in a lengthwise posture and in a state that longer sides of the display surfaces are parallel with each other. At the same time, all the longer sides are perpendicular to a reference plane. A projection optical system is provided with a reflex mirror for perpendicularly bending an optical path. A rotation optical system for rotating projection light by 90 degrees is constituted of the reflex mirror and a plane mirror disposed behind the screen.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: April 4, 2006
    Assignee: Fujinon Corporation
    Inventor: Hitoshi Shimizu
  • Liquid crystal projector
    Patent number: 7004589
    Abstract: A liquid crystal projector of three-color type has three liquid crystal elements for modulating three primary color light bundles into three color optical images respectively. A recombination prism combines modulated three color optical images, and a projection lens system projects the combined full-color image on a screen. The projection lens system is constituted of the front lens group and the first and second rear lens groups. The front lens group and the rear lens groups are mounted to frames that are formed integrally on a prism base plate to which the recombination prism is fixed.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: February 28, 2006
    Assignee: Fujinon Corporation
    Inventor: Hitoshi Shimizu
  • Measuring apparatus and measuring chip
    Publication number: 20060039003
    Abstract: Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.
    Type: Application
    Filed: October 24, 2005
    Publication date: February 23, 2006
    Inventors: Takashi Kubo, Katsuaki Muraishi, Toshihito Kimura, Hitoshi Shimizu, Nobufumi Mori
  • Projecting display apparatus
    Publication number: 20050280779
    Abstract: A projector engine is provided with an illuminating optical system having an optical axis in parallel with a horizontal direction of a screen and a projecting optical system having an optical axis perpendicular to the optical axis. A first mirror, a total reflection prism and DMD are provided between the illuminating optical system and the projecting optical system. The total reflection prism guides illuminating light incident from the illuminating optical system to DMD and totally reflects image light emitted from DMD to emit to the projecting optical system. DMD is inclined by 45 degrees to the horizontal direction of the screen along with a circuit board and is rotated by 45 degrees centering on a direction of a normal line of DMD.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 22, 2005
    Applicant: FUJINON CORPORATION
    Inventor: Hitoshi Shimizu
  • Total reflection prism for projector
    Publication number: 20050275959
    Abstract: A total reflection prism includes two prisms having a shape of a triangular prism of a first prism and a second prism. The first prism includes an illuminating light incident face, a total reflection face and a panel reference face. The second prism includes an image light incident face on which image light is incident from the first prism, an image light emitting face from which image light is emitted, and a side end face. An edge line portion of a sharp edge is formed between the image light emitting face and the side end face and therefore, a light amount of OFF light reflected by the edge line portion and projected to a screen becomes extremely smaller than a light amount of ON light and does not effect an influence on quality of a projected image.
    Type: Application
    Filed: June 8, 2005
    Publication date: December 15, 2005
    Applicant: FUJINON CORPORATION
    Inventors: Satoru Kawaai, Hitoshi Shimizu
  • Liquid crystal projector
    Publication number: 20050237498
    Abstract: A liquid crystal projector of three-color type has three liquid crystal elements for modulating three primary color light bundles into three color optical images respectively. A recombination prism combines modulated three color optical images, and a projection lens system projects the combined full-color image on a screen. The projection lens system is constituted of the front lens group and the first and second rear lens groups. The front lens group and the rear lens groups are mounted to frames that are formed integrally on a prism base plate to which the recombination prism is fixed.
    Type: Application
    Filed: June 16, 2004
    Publication date: October 27, 2005
    Inventor: Hitoshi Shimizu
  • Projection image display apparatus
    Publication number: 20050237628
    Abstract: A projection image display apparatus is equipped with a light shielding member for partially shielding the illumination light from the illuminating optical system so as to reduce the image brightness in a region where the intensity of the reflected light reflected between the on-light and off-light becomes strong, and making the intensity of the illumination light emitted to the respective mirror elements uneven.
    Type: Application
    Filed: April 26, 2005
    Publication date: October 27, 2005
    Applicant: FUJINON CORPORATION
    Inventor: Hitoshi Shimizu
  • Rod integrator holder and projection type image display apparatus having the rod integrator holder
    Patent number: 6934097
    Abstract: A rod integrator holder 6 has concave clearance grooves 67A to 67D elongated in the direction of the optical axis L, at the corners within a case 61 thereof. The clearance grooves 67A to 67D are configured such that the edges 84A to 84D of the rod integrator 8 can be prevented from coming into contact with the inner faces 66A to 66D of the case 61. The edges 84A to 84D of the rod integrator can be prevented from being broken by coming into contact with the inner faces 66A to 66D of the case 61, and the edges 84A to 84D of the rod integrator 8 and the inner faces 66A to 66D of the case 61 can be prevented from rubbing against each other to generate dust due to abrasion.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 23, 2005
    Assignee: Fujinon Corporation
    Inventor: Hitoshi Shimizu
  • Semiconductor laser device having lower threshold current
    Publication number: 20050180485
    Abstract: A semiconductor laser device includes a QW active layer structure including a GaxIn1-xAs1-ySby layer wherein 0.3?1-x and 0.003?y?0.008, or a QW active layer structure including a GaxIn1-xAs1-y2Ny1Sby2 layer wherein 0.3?1-x, 0<y1<0.03 and 0.002?y2?0.06. The semiconductor laser device suppresses the three-dimensional epitaxial growth, and has superior optical characteristics including a low threshold current.
    Type: Application
    Filed: April 18, 2005
    Publication date: August 18, 2005
    Applicant: The Furukawa Electric Co., Ltd.
    Inventors: Hitoshi Shimizu, Koji Kumada
  • Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
    Publication number: 20050176938
    Abstract: Crystal form F of [2S, 4R, 5R, 8R, 9S, 10S, 11R, 12R]-9-[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribo-hexopyranosyl)oxy]-5-ethyl-4-methoxy-2,4,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(isopropylmethylamino)-?-D-xylo-hexopyranosyl]oxy]-6,15-dioxabicyclo[10.2.1]pentadec-14(1)-ene-3,7-dione (E)-2-butenedioic acid salt (2:1) showing strong X-ray diffraction peaks at diffraction angles 2?=6.6° and 8.5°, Crystal form D anhydrate of said compound showing strong X-ray diffraction peaks at diffraction angles 2?=7.1°, 13.5° and 14.2°, Crystal form D X-hydrate of said compound showing strong X-ray diffraction peaks at diffraction angles 2?=7.1° and 14.2° but not showing a strong X-ray diffraction peak at a diffraction angle 2?=13.5°, Solvate Crystal forms G1, G2 and G3 of said compound characterized by 2-theta angle positions in the powder X-ray diffraction pattern of 5.4°, 10.4°, 10.7° and 12.1°.
    Type: Application
    Filed: January 14, 2003
    Publication date: August 11, 2005
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kenji Kamada, Akira Hiraide, Kaichiro Koyama, Hitoshi Shimizu, Gary Ward, Vandana Cheruvallath, Stephan Parent
  • Structure for tightly closing light exit end of rod integrator and rod integrator holder
    Patent number: 6917481
    Abstract: A rod integrator holder comprises a wall constituting at least a part of an intermediate portion interposed between a rod integrator in an illumination optical system or a holding member for the rod integrator, and an optical member disposed downstream the rod integrator or a holding member for the optical member. The intermediate portion tightly closes a space between a light entrance end of the optical member and a light exit end of the rod integrator against surroundings thereof.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: July 12, 2005
    Assignee: Fuji Photo Optical Co., Ltd.
    Inventors: Hitoshi Shimizu, Tadashi Iwasawa
  • Semiconductor laser device having lower threshold current
    Patent number: 6912236
    Abstract: A semiconductor laser device includes a QW active layer structure including a GaxIn1?xAs1?ySby layer wherein 0.3?1?x and 0.003?y?0.008, or a QW active layer structure including a GaxIn1?xAs1?y1?y2Ny1Sby2 layer wherein 0.3?1?x, 0<y1<0.03 and 0.002?y2?0.06. The semiconductor laser device suppresses the three-dimensional epitaxial growth, and has superior optical characteristics including a low threshold current.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 28, 2005
    Assignee: The Furukawa Electric Co., Ltd.
    Inventors: Hitoshi Shimizu, Koji Kumada
  • Surface emitting laser, and transceiver, optical transceiver, and optical communication system employing the surface emitting laser
    Publication number: 20050123014
    Abstract: A surface emitting laser includes a lower semiconductor multilayer mirror formed of a plurality of pairs of a high-refractive-index area and a low-refractive-index area; an active layer vertically sandwiched by cladding layers; a current confinement layer of AlzGa1-zAs having an oxide area in a peripheral portion of the current confinement layer, where 0.95?z?1; and an upper semiconductor multilayer mirror formed of a plurality of pairs of a high-refractive-index area and a low-refractive-index area. The low-refractive-index area of at least one of the lower semiconductor multilayer mirror and the upper semiconductor multilayer mirror includes an Alz1Ga1-z1As layer with a thickness thinner than that of the current confinement layer, where z?z1.
    Type: Application
    Filed: October 5, 2004
    Publication date: June 9, 2005
    Applicant: THE FURUKAWA ELECTRONIC CO., LTD.
    Inventors: Hitoshi Shimizu, Setiagung Casimirus, Yasukazu Shiina, Takeshi Hama, Norihiro Iwai
  • Process for producing erythromycin derivative
    Patent number: 6897299
    Abstract: A method for preparing a fumarate salt of a compound represented by Formula (II): (wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents a lower alkyl group), which comprises carbamating a compound represented by Formula (I): (wherein R1 represents a hydrogen atom or a lower alkyl group), removing all carbamate groups from this compound, alkylating the nitrogen atom at the 3?-position of the desosamine ring in the resulting compound to give the compound represented by Formula (II), and converting this compound into a fumarate salt, wherein the compound represented by Formula (I) is carbamated in the presence of a cyclic ether or a carboxylic ester. This method enables efficient preparation of high-quality erythromycin derivatives.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: May 24, 2005
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Shimizu, Kaname Tsuzaki, Mitsuhiro Kurita
  • Measuring apparatus
    Patent number: 6885454
    Abstract: A measuring apparatus is disclosed which includes a measuring unit equipped with a dielectric block and a thin film layer; an incidence system for making a light beam enter the dielectric block so that a condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer; and a photodetector for receiving the light beam totally reflected at the interface. The measuring unit is measured a plurality of times, and a change in the state of attenuated total reflection during the plurality of measurements is detected. The sensor further includes a tilt measurement section for measuring the longitudinal tilt of the interface which changes the incidence angles during the plurality of measurements, and a calculating section for obtaining a measured value in which errors due to the longitudinal tilt have been corrected.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: April 26, 2005
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masayuki Naya, Nobufumi Mori, Toshihito Kimura, Hitoshi Shimizu, Shu Sato
  • Measuring apparatus and sensor unit for same
    Publication number: 20050046854
    Abstract: A sensor unit includes a dielectric block, a thin film layer and a reference surface. The thin film layer is formed on the upper surface of the dielectric block and the reference surface is coplanar with the upper surface of the dielectric block. The sensor unit is held in a predetermined position. A light beam is caused to enter the dielectric block to impinge upon the interface between the upper surface of the dielectric block and the thin film layer so that total internal reflection conditions are satisfied at the interface. Information on an analyte on the thin film layer is obtained on the basis of the light beam reflected at the interface. Displacement of the interface is measured by measuring displacement of the reference surface and the position of the sensor unit is adjusted according to the displacement of the reference surface.
    Type: Application
    Filed: September 2, 2004
    Publication date: March 3, 2005
    Inventors: Yoshiyuki Kunuki, Hitoshi Shimizu, Toshihito Kimura