Abstract: Multiple polynucleotides having different, arbitrary sequences are synthesized on the surface of an array by spatial control of polymerase activity. The polymerase is a template-independent polymerase such as terminal deoxynucleotidyl transferase (TdT). Spatial control of polymerase activity is implemented by localized changes in redox-pH conditions. A single species of nucleotide is added and incorporated on growing polynucleotide strands at locations on the array where the polymerase is active. A washing step removes the polymerase and free nucleotides. This process may be repeated multiple times changing both the location of polymerase activity and the species of nucleotide thereby synthesizing different polynucleotides in parallel on the surface of the array. Polymerase activity may be regulated by removing a blocking group attached to a His-tag sequence on the polymerase, a change in pH, or release of encapsulated inhibitors.

Abstract: An indexing valve system includes a tubular having an inner surface portion defining a passage portion, a first plurality of indexing components provided on the inner surface and a second plurality of indexing components provided on the inner surface portion. A valve sleeve is arranged in the passage portion. The valve sleeve includes a first plurality of indexing elements that selectively engage with the first plurality of indexing components, a second plurality of indexing elements that selectively engage with the second plurality of indexing components, and an inner surface section defining a passage section. The inner surface section includes a plurality of indexing step members. An insert extends into the passage section. The insert includes an outer surface supporting an indexer that selectively engages with the plurality of indexing step members to shift the valve sleeve between the first plurality of indexing components and the second plurality of indexing components.

Abstract: A system for facilitating acquisition of items on behalf of a requesting device is provided. The system comprises an application that when executed on a computer publishes a listing of items specified by a first device, the items available from online vendors designated in the specification. The system also receives an instruction from a second device to purchase a first item in the listing of items. The system also purchases, based on the instruction, the first item from a first online vendor of the online vendors, and directs the first online vendor to ship the first item to a specified address. The specified address is provided by the first device. The system further verifies availability and price of the first item with the first online vendor prior to purchasing.

Abstract: Decoder for decoding a picture from a data stream, configured to check whether a plurality of coding parameters, which are contained in the data stream, relate to a predetermined portion of the picture and control a prediction residual transform mode and a quantization accuracy with respect to the predetermined portion, are indicative of a coding parameter setting corresponding to a lossless prediction residual coding. Responsive to the plurality of coding parameters being indicative of the coding parameter setting corresponding to the lossless prediction residual coding, the decoder is configured to set one or more predetermined coding options relating to one or more tools of the decoder for processing a prediction residual corrected predictive reconstruction with respect to the predetermined portion so that the one or more tools are disabled with respect to the predetermined portion.

Abstract: An electronic device includes a transparent member arranged on at least one of a front surface or a rear surface of the electronic device and including a first region facing a display module, a housing surrounding the transparent member, including a sidewall extending in a circumferential direction of the electronic device, and forming an exterior of the electronic device, and protruding portions protruding toward the transparent member from the sidewall and extending in the circumferential direction of the electronic device, wherein a distance between the protruding portions facing each other with the transparent member therebetween is less than a width of the transparent member arranged between the protruding portions.

Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-? dielectric, a low-? dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds.

Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.

Abstract: A fin sealer and method to seal a radially outwardly directed fin of a tubular web structure by directing the fin through a nip between a first and a second fin sealing rollers while communicating heat to the fin through at least one of the fin sealing rollers is provided. The fin sealer is configured to maintain a nominal face-to-face relation between an outer annulus of the first fin sealing roller and an outer annulus of the second fin sealing roller with a flexible connection between a hub element of the second fin sealing roller with the outer annulus of the second fin sealing roller.

Abstract: A cartridge of an intraocular lens (IOL) inserter includes an insertion nozzle, having a distal insertion channel; an IOL-folding stage, having a proximal insertion channel; and a haptic protection structure to protect a trailing haptic of the IOL from damage by a push-rod of the inserter. The haptic protection structure includes a proximal guiding groove in the IOL-folding stage, or a distal guiding groove in the insertion nozzle. The haptic protection structure further includes a trailing-haptic notch, to guide a trailing haptic protruding from the proximal guiding groove; and a trailing-haptic retainer, to secure the trailing haptic out of the proximal insertion channel. An intraocular lens inserter includes an inserter cylinder; a push-rod in the inserter cylinder; a cartridge-receiving insertion tip, to receive a cartridge that includes an insertion nozzle, having a distal insertion channel; an intra-ocular lens-folding stage, having a proximal insertion channel; and a haptic protection structure.

Abstract: A wireless-access point includes a first radio to transmit RF signals in a first channel; a second radio to transmit, simultaneously to transmissions of the RF signals by the first radio, RF signals in a second, non-overlapping channel; and a plurality of planar antennas coupled with corresponding first and second radios to receive the RF signals. First and second planar antennas are coupled with the first radio to receive therefrom, in the first channel, a first RF signal and a second RF signal, respectively. The first planar antenna is arranged with its normal along a first direction. The second planar antenna is arranged with its normal along a second, different direction. A third planar antenna is coupled with the second radio to receive therefrom a third RF signal in the second channel, the third planar antenna being arranged with its normal along a third direction.

Abstract: The present disclosure provides an apparatus for forming a stream of individual packets, comprising a folder arranged to form a tubular web structure, a feeder arranged to feed the formed tubular web structure to a nip; a first rotor comprising a first sealing jaw and a knife, a second rotor comprising a second sealing jaw and an anvil, the sealing jaws, the knife and anvil rotating into opposing relation at the nip so as to form a severed, completed packet beyond the nip. The apparatus includes an open ended packet catcher adjacent the first and second rotors, which is arranged to catch the severed, completed packets beyond the nip whereby a stream of packets is established.

Abstract: Provided is an electronic device including: a housing; a camera module oriented in a first direction inside the housing; a camera window arranged in front of the camera module in the first direction; a cover including an opening into which the camera window is insertable, the cover coupled to the housing; and a window frame supporting the camera window and mounted on the cover. The window frame includes: a frame body including a support portion arranged in the opening and supporting the camera window, and a mounting portion extending from the support portion in a second direction that is perpendicular to the first direction and overlapped by the cover in the first direction; a retention member retaining a first gap between the mounting portion and the cover in the first direction; and a waterproof body configured to be elastically deformed while arranged between the mounting portion and the cover.

Abstract: The disclosed technology relates to a network agent for generating platform specific network policies. A network agent is configured to receive a platform independent network policy from a network policy system, determine implementation characteristics of the network entity, generate platform specific policies from the platform independent network policy based on the implementation characteristics of the network entity, and implement the platform specific policies on the network entity.

Abstract: Provided herein is a rechargeable power source that can be quickly charged and used for charging mobile and cordless devices. The power source includes an ultracapacitor which comprises a composite structure including, for example open graphene structures or graphene nanoribbons attached to an oxide layer. The oxide layer is on a metal foil surface. The oxide layer includes more than one metal atom.

Abstract: Polynucleotides such as DNA are stored inside vesicles formed from self-assembling membranes. The vesicles may be protocells, liposomes, micelles, colloidosomes, proteinosomes, or coacervates. The vesicles may include surface functionalization to improve polynucleotide encapsulation and/or to bind polynucleotides having specific sequences. Encapsulation in vesicles provides protection for the polynucleotides. Additional protection is provided by addition of one or more stabilizers. The stabilizer may be nucleic-acid stabilizers that stabilize the polynucleotides or may be a protective structural layer around the vesicles such as a layer of silica. A process for stably storing polynucleotides in vesicles and a process for recovering stored polynucleotides from vesicles are both disclosed. The polynucleotides may be used for storage of digital information.

Abstract: A method for DNA synthesis using protected nucleosides is disclosed. The nucleosides may be nucleoside triphosphates or nucleoside phosphoramidites with nucleobases attached to electrochemically-cleavable linkers. Removal of a protecting group by application of a voltage in solution triggers a cyclization reaction that cleaves the electrochemically-cleavable linkers. The electrochemically-cleavable linkers may include an amide linkage and an amide that forms a lactam or an ester linkage and a protected alcohol that forms a lactone when the protecting group is removed. The voltage used to cleave the electrochemically-cleavable linkers may be generated by activation of individual electrodes on a microelectrode array. The microelectrode array can be a substrate for solid-phase synthesis of oligonucleotides. Activation of specific electrodes removes the protecting groups at those electrodes and thus enables spatially-controlled extension of the oligonucleotides.

Abstract: A power output control and compensation (PCC) circuit operates within a distributed energy resource (DER) system. The PCC circuit is located in a battery power conversion system (PCS) and includes an input terminal to connect with a power source and an output terminal to connect with an electrical panel or load. A current sensing device is coupled between the input and the output terminals to measure a power level of the power source. A relay is coupled between the current sensing device and the output terminal and a processor selectively connects power from the power source to the electrical panel or the load based on the measured power level or based on other power measurements within the DER system. PCS-control of multiple power sources decreases cycle times for controlling distributed energy resources.

Abstract: The disclosed technology relates to intent driven network management. A system is configured to maintain an inventory store comprising records for a set of network entities in a network, wherein each network entity in the set of network entities is associated with a record in the inventory store. The system receives a user intent statement comprising an action and a flow filter representing network data flows on which the action is to be applied and queries, based on the flow filter, the inventory store to identify a plurality of network entities in the set of network entities to which the user intent statement applies. The system generates a plurality of network policies that implement the user intent statement based on the plurality of network entities and the action and enforces the plurality network policies.

Abstract: One motor is shared for carriage movement and document sheet conveyance. An abutting member stops the carriage, that has moved from a second position located below a first end portion of a platen glass, at a first position located below a contact glass. The carriage supports the motor and first and second main body gears. The main body gears interlock with the motor. A cover input gear meshes with the first main body gear when the carriage is located between the first position and a relay region. A main rack gear meshes with the second main body gear when the carriage is located in a region extending from the relay region to a third position located below a second end portion of the platen glass. A load torque applied to the motor is larger when the carriage is fixed than when the cover input gear is fixed.

Abstract: The present disclosure provides compounds that may be used as ligands in metal-catalyzed reactions, in particular 3,3?-bisilyl biaryl phosphoramidite compounds and processes for preparing the same.