Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Abstract: Electrodes, electrolytes and/or separators for energy storage devices comprising functional boron-containing chemicals are disclosed. The energy storage device comprises a first electrode and a second electrode, wherein at least one of the first electrode and the second electrode is a Si-based electrode, a separator between the first electrode and the second electrode, and an electrolyte composition. Functional boron-containing chemicals may serve as additives to one or more of the electrodes, electrolyte and/or separator.

Abstract: The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

Abstract: A method for key predictors and machine learning for configuring battery cell performance may include providing a cell that includes a cathode, a separator, and a silicon-dominant anode; measuring a plurality of parameters of the cell; and using a machine learning model to determine cycle life based on the plurality of measured parameters, where one of the measured parameters includes second cycle coulombic efficiency. The plurality of parameters may include initial coulombic efficiency, cell impedance values, open-circuit voltage, cell thickness, and impedance after degassing. A first subset of the plurality of parameters may be measured before a formation process. A second subset of the plurality of parameters may be measured during a formation process, where the plurality of parameters may include a voltage reached during a first 10% of a first formation cycle. A third subset of the plurality of parameters may be measured during cycling of the cell.

Abstract: A method for preparing a silicon monoxide composite material includes: a first stage: introducing a protective gas into a vapor deposition oven, and pre-heating a silicon monoxide raw material, such that a part of the silicon monoxide raw material is subjected to a disproportionation reaction; a second stage: continuously introducing the protective gas and introducing a carbon source gas, and subjecting the pre-heated silicon monoxide raw material to a chemical vapor deposition to form carbon nanotubes on a surface of silicon monoxide; and a third stage: after a predetermined time period, stopping introducing the carbon source gas, and stopping introducing the protective gas until the vapor deposition oven is cooled to room temperature, to prepare the silicon monoxide composite material. During the preparation process, no extra catalyst needs to be added, a product of the previous disproportionation reaction may act as a catalyst for the growth of the carbon nanotubes.

Abstract: Systems and methods are provided for polarization compensation in silicon-dominant electrode cells. One or more adjustments to operation of a silicon-dominant cell maybe applied based on effects of polarization in the silicon-dominant cell during charge/discharge cycles, with the one or more adjustments configured to compensate for at least some of the effects of polarization in the silicon-dominant cell.

Abstract: A method for key predictors and machine learning for configuring battery cell performance may include providing a cell that may include a cathode, a separator, and a silicon-dominant anode; measuring a plurality of parameters of the cell; and using a machine learning model to determine cell performance based on the plurality of measured parameters. The plurality of parameters may include initial coulombic efficiency and/or second cycle coulombic efficiency. Cells may be classified based on the determined cell performance and similarly performing cells may be binned together. A battery pack may be provided with a plurality of cells. The plurality of cells may be assessed during cycling using the machine learning model. One or more of the plurality of cells may be replaced when the assessing determines a different performance of the one or more of the plurality of cells. The battery pack may be in an electric vehicle.

Abstract: In an approach, data of a plurality of points is sampled in a target area, wherein the data of each point of the plurality of points comprises position information and a height value. A first area of a target area is determined, wherein the height value of each point of the plurality of points in the first area complies with a first range. A second area of the target area is determined, wherein the height value of each point of the plurality of points in the second area complies with a second range. A third area of the target area is determined, wherein the height value of each point of the plurality of points in the third area complies with a third range. A first pattern is generated, wherein the first pattern is a combination of the first area and the third area.

Abstract: Embodiments of the present disclosure relate to a method, system, and computer program product for webpage customization. In some embodiments, a method is disclosed. According to the method, a webpage to be provided to a user is obtained. The webpage comprises at least a first element having a first set of style attributes. A second element matching the first element is determined from a set of elements customized for the user. The second element has a second set of style attributes. The webpage is customized for the user by applying at least part of the second set of style attributes to the first element. The customized webpage is provided to the user. In other embodiments, a system and a computer program product are disclosed.

Abstract: Computer-based methods and systems provide automated batch data alignment for a batch production industrial process. An example embodiment selects a reference batch from batch data for a subject industrial process and configures batch alignment settings. In turn, a seed model configured to predict alignment quality given settings for one or more alignment hyperparameters is constructed. Collectively the selected reference batch, the configured batch alignment settings, the constructed seed model, and a set of representative batches, representative of the batch data for the industrial process, are used to perform at least one of: (i) automated active learning, (ii) interactive active learning, and (iii) guided learning to determine settings for the one or more alignment hyperparameters. Then, a batch alignment is performed using the determined settings for the one or more alignment hyperparameters and the configured batch alignment settings.

Abstract: A method, including: obtaining, with a computer, an initial geophysical model; modeling, with a computer, a forward wavefield based on the initial geophysical model with wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium; modeling, with a computer, an adjoint wavefield with adjoint wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium, wherein the wave equations and the adjoint wave equations include relaxation terms accounting for anelasticity of earth in an update of a primary variable and an evolution relationship for the relaxation terms; and obtaining, with a computer, a gradient of a cost function based on a combination of a model of the forward wavefield and a model of the adjoint wavefield.

Abstract: An electronic device is for identifying a LED driver which is a switched mode power supply. For example the LED driver is part of an LED luminaire. An interface (24) is adapted to be coupled to a high frequency power commutation component of the switched mode power supply, for sensing the high frequency power commutation of the switched mode power supply in driving the LED. A mapping is made between identifications of LED drivers which are switched mode power supply and characteristics of the high frequency power commutations in driving the LED of a respective switched mode power supply. Thus, a LED driver which uses a switched mode power supply can be identified corresponding to extracted characteristics of the high frequency power commutations in driving the LED. This identification can be used for energy monitoring and fault diagnosis purposes, for use in a universal low cost LED driver.

Abstract: The invention relates to medicines, and more particularly to an abortion medication and an administration thereof, where the abortion medication contains 40-60 mg/mL of a kidney bean lectin. The invention also provides another abortion medication, which contains 40-60 mg/mL of a kidney bean lectin, 40-50 mg/mL of an oligosaccharide and 6-9 mg/mL of NaCl. The two abortion medications provided herein are both capable of effectively terminating the pregnancy and are safe without toxic side effects. Moreover, these drugs can be reused several times. These abortion medications are administered intrauterinely, which enables the kidney bean lectin therein to show the best abortive effect, and the local administration of these drugs in the uterine cavity has relatively simple operation.

Abstract: The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

Abstract: A fast charge lithium ion battery capable of being charged or discharged with 80% capacity retention at C rate of at least 2C is provided in the present invention, which includes a fast charge graphite-based anode; a cathode; and a separator, wherein the anode includes an anode current collector and a fast charge graphite layer deposited on at least one surface of the anode current collector, the fast charge graphite having a lattice constant equals to or larger than 0.3374 nm, a D-band to G-band integrated area ratio (ID/IG) of 0.03 to 0.3, and a surface morphology of a plate-like crystal structure under a scanned electron microscope; the cathode includes a cathode current collector and one or more active materials deposited on at least one surface of the cathode current collector.

Abstract: The present disclosure provides a manufacturing process of an arc-shaped bottom titanium cup, including: S1: pressing an inner support ring; S2: primary crystallization; S3: matching; S4: welding opening parts; S5: pressing a titanium cup vacuum bottom; S6: welding the titanium cup vacuum bottom; S7: secondary crystallization; S8: vacuumizing; S9: detecting a thermal insulation function; S10: welding a titanium cup bottom plate; S11: surface polishing; and S12: oxidation processing. The present disclosure provides an inner support ring structure, the inner support ring always holds the titanium cup vacuum bottom round and maintains the titanium cup vacuum bottom in a high degree of roundness, thereby ensuring that a surface of a titanium cup shell and a titanium cup vacuum bottom is flat and smooth. The arc-shaped bottom titanium cup is clamped by adopting an upper mold and a lower mold, so that the arc-shaped bottom titanium cup is accurately limited.

Abstract: The invention provides an antenna structure comprising a plurality of wire segments formed in a loop. Connecting units are provided between the wire segments, each of which is switchable between a conductive state and a reactive state. With the connecting units in the conductive state a loop antenna is formed with a first (longer) signal range and with the connecting units in the reactive state an antenna structure is formed with a second (shorter) signal range. Said reactive state is adapted to introduce a phase delay between the adjacent wire segments. This enables the same antenna to be used for long range signal communication and short range communication, for example for system configuration or commissioning. The antenna structure may be used with luminaires of a lighting system.

Abstract: Provided herein are anode assembly, conductive contact strips, electrochemical cells containing the anode assembly and the conductive contact strips, and methods to use and manufacture the same, where the anode assembly includes a plurality of V-shaped, U-shaped, or Z-shaped elements positioned outside the anode shell and in electrical contact with the anode.

Abstract: An electrohydrodynamic (EHD) jet printing apparatus or system may include circulation of printing fluid to minimize or eliminate clogging in a nozzle. An exemplary nozzle comprises at least two ink channels—one allowing flow to a droplet emitting opening and one allowing flow away from the droplet emitting opening—configured for circulating ink. The nozzle may transfer ink to a substrate with an EHD technique involving voltage or current modulation. For example, an electric field may be applied between the nozzle and printing substrate such that the ink meniscus changes shape and releases ink from the tip of the liquid cone. A multi-channel nozzle may take a variety of configurations, including two co-axially aligned capillaries, side-by-side parallel capillaries, or capillaries arranged at an angle with respect to one another but converging at a single point where the conical meniscus is formed.

Abstract: A method and system for estimating wax or hydrate deposits is desirable for the oil industry and important for assuring flow conditions and production, avoiding downtime, and reducing or preventing costly interventions. The method and system disclosed herein use artificial intelligence and machine learning techniques combined with oil well historical operational sensor data and historical operational event records (such as diesel hot flush, slick line, coil tubing, etc.) to build an oil well model. The method and system enable oil well practitioners to test and validate the built model and deploy the model online to estimate and/or detect wax or hydrate deposition status. By using one or more such models in operating an oil well, users can monitor and/or detect the status of wax of hydrate deposits in an oil well and can optimize production, maintenance, and planning for oil wells.