Abstract: A cationic latex fixative for ink applications is provided. The cationic latex fixative derived from a combination of a cationic monomer, a nonionic monomer that provides softness to the latex, and a nonionic monomer that provide stiffness to the latex. A method of manufacturing the fixative and a method of printing the fixative are also provided.

Abstract: In an example of a three-dimensional (3D) printing method, a polymeric or polymeric composite build material is applied. A fusing agent is selectively applied on at least a portion of the polymeric or polymeric composite build material. The fusing agent includes a discolorable near-infrared absorbing dye, a thiol surfactant, a reducing agent, and a balance of water. Near-infrared radiation is applied to the polymeric or polymeric composite build material at a condition that maintains a temperature of the selectively applied fusing agent below a decomposition temperature of the fusing agent and that allows the discolorable near-infrared absorbing dye to harvest near-infrared radiation energy, in order to fuse the portion of the polymeric or polymeric composite build material in contact with the fusing agent to form a layer and to initiate discoloration of the discolorable near-infrared absorbing dye in the layer.

Abstract: A three-dimensional object may be generated. Energy may be applied to a layer of build material to cause a first portion of the layer to coalesce and solidify in a first pattern. A cooling agent may be selectively delivered on a second portion of the layer of the build material to reduce a temperature of the second portion in a second pattern, the first and second patterns being independent of each other.

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: An example of a fusing agent includes a tetraphenyldiamine-based dye, alkyldiphenyloxide disulfonate, 1-methyl-2-pyrrolidone, and a balance of water. The fusing agent excludes a strong reducing species. The fusing agent may be incorporated into a three-dimensional printing method or a three-dimensional printing system. In an example of the three-dimensional printing method, a polymeric or polymeric composite build material is applied. The fusing agent is selectively applied on at least a portion of the polymeric or polymeric composite build material. The polymeric or polymeric composite build material is exposed to electromagnetic radiation to fuse the portion of the polymeric or polymeric composite build material in contact with the fusing agent to form a layer.

Abstract: In an example of a three-dimensional (3D) printing method, a crystalline or semi-crystalline build material is applied. A temperature of the crystalline or semi-crystalline build material is maintained within 100° C. below a melting point of the crystalline or semi-crystalline build material. A melt flow property reduction agent is applied to at least a portion of the crystalline or semi-crystalline build material, and the at least the portion of the crystalline or semi-crystalline build material in contact with the melt flow property reduction agent melts or coalesces at the temperature.

Abstract: A multi-layer device comprising a first substrate, a first electrically conductive layer and a first current modulating structure on a surface thereof, the first current modulating structure comprising a composite of a resistive material and a patterned insulating material, the first current modulating structure having a cross-layer resistance to the flow of electrical current through the first current modulating structure that varies as a function of position.

Abstract: An ophthalmic technician is present with a patient in an exam room to operate eye examination equipment and transmit patient information to remote location. At that remote location, a skilled technician is present to provide the necessary optical care, and may operate the phoropter from the remote location. Using video and/or teleconferencing equipment and a phoropter located in the patient examination room along with management software, the system works to determine the final optical prescription for the patient. That information, coupled with findings from other devices which are integrated with the management software, and that the patient uses locally, are reviewed by a remote-based optometrist or ophthalmologist.

Abstract: The present disclosure is drawn material sets, coalescent fluids, and 3-dimensional printing systems. An example material set can include an amorphous polymer powder having an average particle size from 1 micron to 300 microns, and a coalescent fluid including a viscosity reducing agent.

Abstract: In an example of a three-dimensional (3D) printing method, a polymeric build material is applied. A fusing agent is selectively applied on at least a portion of the polymeric build material. A mechanical tailoring agent is selectively applied on at least a region of the portion. The polymeric build material is exposed to radiation, thereby fusing the at least the portion of the polymeric build material in contact with the fusing agent to form a layer. The mechanical tailoring agent forms a composite layer in the at least the region, and the composite layer has a different mechanical property than that of an area of the layer not in contact with the mechanical tailoring agent.

Abstract: According to an example, a composition may include a high melt temperature build material in the form of a powder; a first low melt temperature binder in the form of a powder; and a second low melt temperature binder in the form of a powder, and in which the first low melt temperature binder melts at a temperature that is different from the second low melt temperature binder.

Abstract: A three-dimensional (3D) printing method includes applying a build material composition having a polymer particle and a radiation absorbing additive mixed with the polymer particle, the radiation absorbing additive being selected from the group consisting of inorganic near-infrared absorbers, organic near-infrared absorbers, and combinations thereof. The build material composition is preheated to a temperature below the melting temperature of the polymer particle by exposing the build material composition to radiation, the radiation absorbing additive increasing radiation absorption and accelerating the pre-heating of the build material composition. A fusing agent is selectively applied on at least a portion of the build material composition. The method further includes exposing the build material composition to radiation, whereby at least the polymer particle in the at least the portion of the build material composition in contact with the fusing agent at least partially fuses.

Abstract: The present disclosure is drawn to coalescent inks and material sets, such as for 3D printing. In one example, the coalescent ink can include a conjugated polymer, a colorant imparting a visible color to the coalescent ink, and an ink vehicle comprising a high boiling point co-solvent having a boiling point of 250° C. or greater. The high boiling point co-solvent can be present in an amount from about 1 wt % to about 4 wt % with respect to the coalescent ink.

Abstract: A side-firing laser system with a standoff catheter includes an optical fiber configured to emit therapeutic laser radiation in a direction generally transverse to an axis of the fiber; and a catheter through which the optical fiber is inserted during a surgical procedure. The catheter includes a transparent end section through which the therapeutic laser radiation passes to vaporize tissue outside the catheter, an open distal end to permit exit of irrigation fluid from the catheter, and an opening in a side of the end section, the opening having dimensions that are approximately equal to or less than cross-sectional dimensions of the therapeutic laser radiation. When the fiber is moved to a position at which the therapeutic laser radiation passes through the opening, the laser radiation causes coagulation or vaporization of tissues.

Abstract: In one embodiment, a transdermal patch includes a substrate and a layer of pressure-sensitive adhesive provided on the substrate, the pressure-sensitive adhesive comprising a blend of an adhesive compound and a carrier-drug compound, the carrier-drug compound comprising a drug transport compound and a drug that is to be delivered to the skin of a subject, wherein the drug transport compound transports the drug through the pressure-sensitive adhesive to the skin

Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Abstract: In an example of a method for forming three-dimensional (3D) printed electronics, a build material is applied. A fusing agent is selectively applied on at least a portion of the build material. The build material is exposed to radiation and the portion of the build material in contact with the fusing agent fuses to form a layer. An electronic agent is selectively applied on at least a portion of the layer, which imparts an electronic property to the at least the portion of the layer.

Abstract: Apparatus and methods for making metal-connected particle articles. A metal containing fluid is selectively applied to a layer of particles. The metal in the fluid is used to form metal connections between particles. The metal connections are formed at temperatures below the sintering temperature of the particles in the layer of particles.

Abstract: A multi-layer device comprising a first substrate, a first electrically conductive layer and a first current modulating structure on a surface thereof, the first current modulating structure comprising a composite of a resistive material and a patterned insulating material, the first current modulating structure having a cross-layer resistance to the flow of electrical current through the first current modulating structure that varies as a function of position.

Abstract: A multi-layer device comprising a first substrate, a first electrically conductive layer on a surface thereof, and a first current modulating layer, the first electrically conductive layer having a sheet resistance to the flow of electrical current through the first electrically conductive layer that varies as a function of position.