Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Methods for cutting strengthened glass are disclosed. The methods can include using a laser. The strengthened glass can include chemically strengthened, heat strengthened, and heat tempered glass. Strengthened glass with edges showing indicia of a laser cutting process are also disclosed. The strengthened glass can include an electrochromic film.

Abstract: A wirelessly powered inflatable medical implant system includes a medical provider software application, a patient external controller and a MR-Conditional, nonferrous pump in reservoir implant. The medical provider software application programs the patient external controller for the patient to transmit wireless power and control signals to circuitry in a pump in reservoir implant. In response, the pump in reservoir implant, containing a fluid reservoir and pump package submerged therein, transfers fluid from the reservoir through tubing, and into one or more inflatable medical implants. Submerging the pump package within the reservoir simplifies surgery in males and pump placement in females and provides pump package heatsinking to limit implant overheating.

Abstract: A device includes a carriage movable relative to a build pad along a bi-directional travel path and supporting at least a radiation source and an applicator to selectively apply a plurality of fluid agents, including first fluid agents to affect a first material property. A timing and order of operation of the radiation source and the applicator, with the carriage, is to maintain first and second portions of a 3D object under formation within at least one selectable temperature range despite a first total volume of the first fluid agents for application onto the first portion of the 3D object being substantially greater than a second total volume of second fluid agents for application onto the second portion of the 3D object.

Abstract: Methods of forming 3D printed metal objects and compositions for 3D printing are described herein. In an example, a method of forming a 3D printed metal object can comprise: (A): a build material comprising at least one metal being deposited; (B): a fusing agent being selectively jetted on the build material, the fusing agent comprising: (i) at least one hydrated metal salt having a dehydration temperature of from about 100° C. to about 250° C., and (ii) a carrier liquid comprising at least one surfactant and water; (C): the build material and the selectively jetted fusing agent being heated to a temperature of from about 100° C. to about 250° C. to: (a) remove the carrier liquid, (b) dehydrate the hydrated metal salt, and (c) bind the build material and the selectively jetted fusing agent; and (D): (A), (B), and (C) being repeated at least one time to form the 3D printed metal object.

Abstract: An ophthalmic technician is present with a patient in an exam room to operate eye examination equipment and transmit patient information to remote location. At that remote location, a skilled technician is present to provide the necessary optical care, and may operate the phoropter from the remote location. Using video and/or teleconferencing equipment and a phoropter located in the patient examination room along with management software, the system works to determine the final optical prescription for the patient. That information, coupled with findings from other devices which are integrated with the management software, and that the patient uses locally, are reviewed by a remote-based optometrist or ophthalmologist.

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A multi-layer device comprising a first substrate and a first electrically conductive layer on a surface thereof, the first electrically conductive layer having a sheet resistance to the flow of electrical current through the first electrically conductive layer that varies as a function of position.

Abstract: An example of a fusing agent includes a tetraphenyldiamine-based dye, alkyldiphenyloxide disulfonate, 1-methyl-2-pyrrolidone, and a balance of water. The fusing agent excludes a strong reducing species. The fusing agent may be incorporated into a three-dimensional printing method or a three-dimensional printing system. In an example of the three-dimensional printing method, a polymeric or polymeric composite build material is applied. The fusing agent is selectively applied on at least a portion of the polymeric or polymeric composite build material. The polymeric or polymeric composite build material is exposed to electromagnetic radiation to fuse the portion of the polymeric or polymeric composite build material in contact with the fusing agent to form a layer.

Abstract: Provided herein are salt forms of a complement component 5a receptor having the formula of Compound 1 Also provided herein are pharmaceutical compositions and methods of treatment using the salt forms of Compound 1, described herein.

Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Abstract: Example described herein include a three-dimensional printer a threedimensional printing device that includes a fusible material applicator to apply a layer of fusible material, a inhibiting material applicator to apply a patterned layer of inhibiting material to establish exposed regions of the layer of fusible material and blocked regions of the layer of fusible material based on information corresponding to a three-dimensional model, and a photonic energy emitter to apply photonic energy to fuse the exposed regions of the layer of fusible material.

Abstract: The present disclosure is drawn to coalescent inks and material sets, such as for 3D printing. In one example, the coalescent ink can include a conjugated polymer, a colorant imparting a visible color to the coalescent ink, and an ink vehicle comprising a high boiling point co-solvent having a boiling point of 250° C. or greater. The high boiling point co-solvent can be present in an amount from about 1 wt % to about 4 wt % with respect to the coalescent ink.

Abstract: A multi-layer device comprising a first substrate, a first electrically conductive layer on a surface thereof, and a first current modulating layer, the first electrically conductive layer having a sheet resistance to the flow of electrical current through the first electrically conductive layer that varies as a function of position.

Abstract: A method for controlling an electrochromic device is provided. The method includes applying a constant supply current to the electrochromic device and determining an amount of charge transferred to the electrochromic device, as a function of time and current supplied to the electrochromic device. The method includes ceasing the applying the constant supply current, responsive to a sense voltage reaching a sense voltage limit and applying one of a variable voltage or a variable current to the electrochromic device to maintain the sense voltage at the sense voltage limit, responsive to the sense voltage reaching the sense voltage limit. The method includes terminating the applying the variable voltage or the variable current to the electrochromic device, responsive to the determined amount of charge reaching a target amount of charge.

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A three-dimensional printing build material composition includes a polymer particle, and a radiation absorbing additive mixed with the polymer particle. The radiation absorbing additive has a particle size ranging from about 1 ?m to about 100 ?m, and the radiation absorbing additive is to absorb incident radiation having wavelengths ranging from 700 nm to 10 ?m.

Abstract: Compounds represented by Formula (I) or (II): are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R2a?, R2b?, R2c?, R3?, R4?, R5?, R6a?, Y, Y?, and the subscripts m and n are as defined herein.

Abstract: The present disclosure is drawn material sets, coalescent fluids, and 3-dimensional printing systems. An example material set can include an amorphous polymer powder having an average particle size from 1 micron to 300 microns, and a coalescent fluid including a viscosity reducing agent.