Abstract: A distributed computing system and a fault handling method for a distributed computing system. In the distributed computing system, both a computing node group and a backup node access a switching device, and when detecting that a fault occurs in the computing node group, a management node in the distributed computing system may configure the switching device to establish a data exchange path between the backup node and the computing node group.

Abstract: A method for backing up data includes determining, based on storage information of data stored in a primary storage system, tiering information of the data. The method further includes determining, based on the tiering information, storage locations corresponding to target data for backing up and backup data corresponding to the target data, where the storage locations are located in a cloud end server communicated with the primary storage system. The method further includes controlling, based on the storage locations, the cloud end server to store the backup data to a corresponding tier in the cloud end server. In this way, the tiering information can be introduced during a backup process, enabling a backup storage system to directly acquire storage information of data and store the storage information in a corresponding tier, so as to save storage cost for users while ensuring security and availability of the data.

Abstract: Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event.

Abstract: A method for backing up data includes: determining a storage tier for storing the data; determining a data access frequency of the data, where the data access frequency indicates a frequency at which the data is accessed; and taking information of the storage tier and the data access frequency of the data as metadata, and sending the metadata and the data to a backup server. By sending the information including the storage tier for storing the data and the data access frequency as the metadata to the backup server, the computing device is enabled to recover the data by using the information in the metadata during the data recovery process, so that the data tiering layout can be maintained in the storage region to maintain the storage service performance, and thus a seamless storage service is provided to improve the user experience.

Abstract: Techniques are directed to performing a file system check. Such technique involve determining a plurality of unreleased memory pools for a plurality of phases of a file system check by parsing a resource file indicative of an allocation situation of a memory. Such technique further involve determining a list of phases based on the plurality of unreleased memory pools. Such technique further involve performing the file system check based on the list of phases. Accordingly, it is possible to pre-determine an unreleased memory pool based on a resource file and perform a file system check according to the information of the memory pool, which avoids the problems of memory fragmentation and consecutive out-of-memory caused by the unreleased memory pool, thereby solving the out-of-memory error during the execution of the file system check.

Abstract: An electrical connector includes a conductive terminal, an insulated terminal housing, a die-cast housing, a first sealing component and a second sealing component. The insulated terminal housing is at least partially accommodating the terminal. The die-cast housing is at least partially accommodating the terminal housing. The first sealing component is sleeved onto the terminal. The terminal is adapted to be axially inserted into the terminal housing in response to the first sealing component being sleeved onto the terminal, with the first sealing component being pressed against and sealed between the terminal and the terminal housing. The second sealing component is sleeved onto the terminal housing. The terminal housing is adapted to be inserted into the die-cast housing in response to the second sealing member being sleeved onto the terminal housing, with the second sealing component being pressed against and sealed between the terminal housing and the die-cast housing.

Abstract: Techniques collect or shoot memory bullets. Each magazine includes at least one address pointer for at least one memory bullet. Such techniques involve: obtaining memory bullets to be collected or shot; determining whether remaining address pointers in multiple magazines of a first core have a capacity to collect or shoot a memory bullet; and borrowing a magazine as needed from a second core in response to determining that the remaining address pointers in the first core have no capacity to collect or shoot a memory bullet. Such techniques can achieve a balance of magazines among multiple cores, thereby facilitating memory pool allocation.

Abstract: The present disclosure provides a muscle-specific chimeric promoter, including: (1) a hybrid ?-myosin heavy chain enhancer/muscle creatine kinase enhancer-promoter (MHCK7 promoter); and (2) one or more binding sites of a transcription factor, wherein the MHCK7 promoter includes the sequence set forth in SEQ ID NO: 2 or a functional variant thereof having at least 90% sequence identity to SEQ ID NO: 2, and wherein the transcription factor is a member selected from the group consisting of the MyoD family of transcription factors. Compared with the MHCK7 promoter, the specificity and expression ability in muscle tissue of the muscle-specific chimeric promoter provided in the present application are significantly improved. The application of the muscle-specific chimeric promoter in mammals and muscle cells is of great significance for the treatment of muscle diseases.

Abstract: A method and system for processing a design drawing, an electronic device and a storage medium are disclosed. The method includes: acquiring, from a target application, first coordinate data of a first endpoint, second coordinate data of a second endpoint, first radius data of a first node and second radius data of a second node; obtaining first circle-center coordinate data of the first node according to the first coordinate data, the second coordinate data and the first radius data; obtaining second circle-center coordinate data of the second node according to the first coordinate data, the second coordinate data and the second radius data; and performing a first connection operation on a lofting line segment according to the first circle-center coordinate data and the first coordinate data, and performing a second connection operation on the lofting line segment according to the second circle-center coordinate data and the second coordinate data.

Abstract: Techniques collect or shoot memory bullets. Each magazine includes at least one address pointer for at least one memory bullet. Such techniques involve: obtaining memory bullets to be collected or shot; determining whether remaining address pointers in multiple magazines of a first core have a capacity to collect or shoot a memory bullet; and borrowing a magazine as needed from a second core in response to determining that the remaining address pointers in the first core have no capacity to collect or shoot a memory bullet. Such techniques can achieve a balance of magazines among multiple cores, thereby facilitating memory pool allocation.

Abstract: A method for backing up data includes: determining a storage tier for storing the data; determining a data access frequency of the data, where the data access frequency indicates a frequency at which the data is accessed; and taking information of the storage tier and the data access frequency of the data as metadata, and sending the metadata and the data to a backup server. By sending the information including the storage tier for storing the data and the data access frequency as the metadata to the backup server, the computing device is enabled to recover the data by using the information in the metadata during the data recovery process, so that the data tiering layout can be maintained in the storage region to maintain the storage service performance, and thus a seamless storage service is provided to improve the user experience.

Abstract: Techniques for file system recovery involve: running a recovery task for a file system on a first node, and synchronizing task data associated with the recovery task in a memory of the first node to a memory of a second node during the running of the recovery task. Data of the file system is stored in a storage device that is accessible via the first or second node. Such techniques further involve: in response to the recovery task panicking on the first node, resuming the running of the recovery task on the first node by using the task data that has been synchronized to the memory of the second node. Accordingly, the recovery task for the file system can continue even if some problems are encountered without re-running from the beginning.

Abstract: A data processing method includes obtaining an instruction that carries a target virtual address and a target process identification; querying a mapping table based on the target virtual address and the target process identification, where the mapping table includes a correspondence between at least one virtual address, at least one process identification, and at least one physical address; and if a first physical address corresponding to the target virtual address and the target process identification exists in the mapping table, and the first physical address is included in a physical address range corresponding to the storage class memory, prefetching, to the dynamic random access memory, data of a target memory page corresponding to the first physical address.

Abstract: The present application provides virions and uses thereof in the biological field. The present application specifically provides multiple mutants of an adeno-associated virus with high muscle targeting, quite low liver tropism, and better specificity, and applications thereof. Recombinant adeno-associated viral vectors (rAAV) are constructed using the mutants of the AAV capsid protein provided in this application. The rAAV is not only effective in mouse muscles, but also exhibits better muscle targeting and low liver toxicity in non-human primates (NHP), providing better safety and a wide range of applications.

Abstract: The present disclosure provides a mutant of an adeno-associated virus 2 (AAV2) capsid protein, including an amino acid sequence KTINGSGQNQQTLK (SEQ ID NO: 2) or an amino acid sequence having 1, 2, 3, or 4 amino acid changes when compared to SEQ ID NO: 2 in variable region IV; and an amino acid sequence TTVTQ (SEQ ID NO: 3) or an amino acid sequence having 1 or 2 amino acid changes when compared to SEQ ID NO: 3 in variable region V. The mutants of an adeno-associated virus provided herein have low liver tropism and low hepatotoxicity.

Abstract: Techniques are directed to performing a file system check. Such technique involve determining a plurality of unreleased memory pools for a plurality of phases of a file system check by parsing a resource file indicative of an allocation situation of a memory. Such technique further involve determining a list of phases based on the plurality of unreleased memory pools. Such technique further involve performing the file system check based on the list of phases. Accordingly, it is possible to pre-determine an unreleased memory pool based on a resource file and perform a file system check according to the information of the memory pool, which avoids the problems of memory fragmentation and consecutive out-of-memory caused by the unreleased memory pool, thereby solving the out-of-memory error during the execution of the file system check.

Abstract: Techniques perform data detection. Such techniques involve determining, based on a start sector address of a first mapping range composed of sectors in a physical address space, a first mapping region where the start sector address is located, the first mapping range corresponding to a first virtual block. Such techniques further involve comparing the first mapping region with a second mapping region, a second mapping range corresponding to a second virtual block different from the first virtual block at least partially corresponding to the second mapping region. Such techniques further involve comparing the first mapping range with the second mapping range in response to the first mapping region being the same as the second mapping region. Such techniques further involve determining that the first mapping range overlaps the second mapping range in response to that the first mapping range and the second mapping range have a common range.

Abstract: Disclosed are compounds of Formula (I) and Formula (II), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing, or ameliorating diseases or disorders such as cancer or infections.

Abstract: A method for controlling an internal memory bandwidth includes after obtaining a bandwidth required by a to-be-accessed internal memory medium, a processor in a system obtains an occupancy rate of an internal memory bandwidth of the to-be-accessed internal memory medium. If determining, based on the occupancy rate of the internal memory bandwidth, that the to-be-accessed internal memory medium cannot satisfy a bandwidth requirement, the processor adjusts, under an indication of a bandwidth adjustment policy, the occupancy rate of the internal memory bandwidth based on a factor that affects the occupancy rate of the internal memory bandwidth of the to-be-accessed internal memory medium, and the processor uses a first bandwidth that satisfies the bandwidth requirement in an adjusted remaining bandwidth of the to-be-accessed internal memory medium.