Abstract: This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.

Abstract: A system is described that includes a data warehouse and a platform independent data warehouse load application operable to run on the system. The load application includes a sequencing unit configured to utilize timestamp data from incoming data to be stored in the data warehouse and a relational algebra of set operators to identify and sequence net changes between the incoming data and data previously stored within the data warehouse. The load application is configured to non-intrusively load the identified and sequenced net changes into the data warehouse.

Abstract: The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.

Abstract: A gas turbine engine including a gas generator module and a reduction gearbox module. The gas generator module has an axis which extends longitudinally along a centreline of the gas generator module, and the reduction gearbox module has an axis which extending longitudinally along the centreline of the reduction gearbox and is offset from said generator axis. The reduction gearbox is driven by an intermediate shaft angled relative to the turbine output shaft.

Abstract: A method includes making coiled tubing at a coiled tubing manufacturing unit coupled to a coiled tubing transportation system. One or more coiled tubing reels are transported from the coiled tubing manufacturing unit to one or more moveable well drilling systems using the coiled tubing transportation system. The coiled tubing transportation system runs from the tubing manufacturing unit to one or more movable well drilling systems, and then back to the coiled tubing manufacturing unit.

Abstract: We describe a method for the detection of triacylglycerols (TAGs) in a biological sample.

Abstract: We describe a transgenic plant with altered expression of a gene that encodes a sequence variant of a transcription factor and which has altered seed dormancy.

Abstract: A vibration analysing device for determining the vibrational response of a structural element, comprising: a vibration sensor for providing an output in response to a force input imparted to the structural element; processing means adapted to determine one of a plurality of classifications in response to the output, each classification corresponding to a condition of the structural element; and display means for displaying the determined classification.

Abstract: A centrifuge (10) is provided with improved flying-lead mounting. The centrifuge comprises a cantilevered shaft (18) upon which the main drive rotor (26) is located. A bobbin (62) is attached to the planetary gear shaft (44), which is driven in planetary motion by the rotation of the rotor (26) and its toothed engagement with the shaft (18) of the cantilevered rotor. A flying lead section (72) extends from the bobbin (62) through an aperture in the cantilevered rotor (26) and is provided with a sheath or supporting tube(s) within which at least a portion of inlet and outlet leads are located.

Abstract: A distal component for an interphalangeal prosthesis suitable for insertion into a proximal end of a distal phalangeal bone includes a stem portion shaped to be received within a surgically prepared bore in the proximal end of the distal bone. A head portion has an under-surface and an upper-surface, the under-surface of which in use will bear on the bone into which the stem is implanted.

Abstract: A membrane supported biofilm reactor uses modules having fine, hollow fibres, for example, made from melt spun thermoplastic polymers treated after spinning to increase their permeability to oxygen, used, for example, in tows or formed into a fabric. In one module, one or more sheets of the fabric are potted into a module to enable oxygen containing gas to be supplied to the lumens of the hollow fibres. Various reactors and processes, for example to treat wastewater, using such modules are described. Mechanical, chemical and biological methods, for example endogenous respiration, are used to control the thickness of the biofilm.

Abstract: A membrane supported biofilm reactor uses modules having fine, hollow fibers, for example, made from melt spun thermoplastic polymers treated after spinning to increase their permeability to oxygen, used, for example, in tows or formed into a fabric. In one module, one or more sheets of the fabric are potted into a module to enable oxygen containing gas to be supplied to the lumens of the hollow fibers. Various reactors and processes, for example to treat wastewater, using such modules are described. In one process, oxygen travels through fibers, optionally through an attached biofilm, to oxygenate surrounding water. Mechanical, chemical and biological methods, for example endogenous respiration, are used to control the thickness of the biofilm.

Abstract: A wellstring assembly comprising a tubular first wellstring part with a passageway; a second wellstring part co-operating with the first wellstring part; and a releasable wellstring-interconnecting means for selectively interconnecting the first and second wellstring parts; an auxiliary tool for manipulating the second wellstring part, which auxiliary tool can pass along the passageway in the first wellstring part to the second wellstring part, comprising a tool-connecting means for selectively connecting the auxiliary tool to the second wellstring part, and an operating means for operating the wellstring-interconnecting means.

Abstract: A downhole apparatus such as multi-cycle circulating subs used during downhole drilling operations includes a piston (42) slidably mounted in a body (4) between positions in which at least one aperture (40) in the body is opened and closed. Movement of the piston (42) is controlled by a pin (86) secured to one of the body and a control member, and a control groove (52) in which a portion of the pin is received formed in the other of the body and control member. An arrangement of elements (32,76) respectively connected to the control member and body is such that, as the control member moves axially, increasing lengths of the elements locate adjacent one another so as to provide resistance to relative rotation in at least one direction of the control member and body. The relative rotation is rotation which presses the control member against the control groove. The risk of damage to the control pin is thereby reduced.

Abstract: An object handling device includes a support body, and an elongate anchor body mounted at the inner end thereof to the support body so as to project from the support body for insertion into an undercut cavity in an object to be handled. At least one anchor lug at or adjacent to the outer end of the anchor body is movable with the anchor body between a first position in which the anchor body is able to be inserted into or withdrawn from the cavity, and a second position in which the lug(s) engage respective undercut shoulder portions in the cavity. Means on the anchor body is engagable for moving the anchor body to move the anchor lug(s) between the first and second positions. Lift means on the support body is engagable by a crane to lift the object. Lock means is provided to block movement of the anchor lug(s) from the second position. In one aspect, the anchor body is rotatable to effect said movement of the anchor lug(s).

Abstract: An infant cup includes a cup body 12, a cover 16, a flexible mouthpiece 24 and a valve element 26. The valve element 26 includes a sealing face 70 which closes an orifice 44 in the mouthpiece in a relaxed position. The valve element includes an angled face cooperating with an internal angled face of the mouthpiece such that when pressure is applied the valve element moves downwardly, opening the mouthpiece orifice 44. The valve element is resiliently biased upwards such that when relaxed it springs back to close the mouthpiece orifice 44 once again, and is biased upwards in the closed position.

Abstract: A downhole apparatus permitting separation of one part of downhole equipment from another part thereof includes a first part connected to a second part by a connecting member which limits axial and rotational movement of the first and second parts and has first and second ends connected respectively to the first and second parts. The connecting member includes a cross bar extending between the first and second ends having an aperture therein that results in a region of weakness, a portion of the cross bar spaced from the aperture minimizing stress at the region of weakness when torque is transmitted in use between the first and second parts via the connecting member.

Abstract: A membrane supported biofilm reactor uses modules having fine, hollow fibres, for example, made from dense wall Poly methylpentene (PMP) used in tows or formed into a fabric. In one module, one or more sheets of the fabric are potted into a module to enable oxygen containing gas to be supplied to the lumens of the hollow fibres. Various reactors and processes, for example to treat wastewater, using such modules are described. Mechanical, chemical and biological methods are used to control the thickness of the biofilm.