Abstract: Methods of using phosphotetrahydropyran compounds for treatment of fibrotic and scarring disorders, e.g. pulmonary fibrosis, fibrosis associated with surgical procedures, wound healing disorders, scar formation, sclerotic disorders, ocular fibrotic disorders, ocular healing disorders, ocular fibrosis after surgery, glaucoma, tendon scarring disorders, joint scarring disorders, kidney interstitial fibrosis and glomerular fibrosis and tubular fibrosis of the kidney.

Abstract: A method of calibrating an optical detector arrangement (38,42) comprises simultaneously generating a plurality of entangled photon pairs, such that one photon from each pair traverses a first path (36-38-42) and the other photon from each pair traverses a second path (36-40-44). The number of photons received along the first path is calculated using the detector arrangement (38,42), while the number of simultaneously-generated photons received along the second path is calculated using a second detector arrangement (40,44). These photon numbers are used to calculated an estimate of the detection efficiency (50) of the first detector arrangement (38,42).

Abstract: An apparatus for restraining an object in a vehicle may have an elongated frame, a clamp member mounted to the frame at or near one end thereof, and an elongated base member movably mounted to the frame between the clamp member and an opposite end of the frame. The base member may include a curved portion having a support surface defining a curvature and a linear portion between the curved portion and the clamp member. The base member may be movable relative to the frame to an object transition position in which a free end of the linear portion extends outwardly away from the frame and the curved portion retracts upwardly toward the clamp member along a path defined by the curvature to allow the object to be received between, and removed from between, the clamp member and the support surface of the base member.

Abstract: This invention relates to the use of an antagonist of a G protein-coupled receptor in the prevention and/or treatment of fibrosis, such as the treatment of fibrosis associated with myocardial infarction or diabetes or certain pulmonary conditions. In a preferred embodiment, the antagonist is a C5a receptor antagonist, more preferably a cyclic peptide antagonist of the C5a receptor. In particular, the invention provides a method of prevention, treatment or alleviation of a fibrotic condition, comprising the step of administering an effective amount of an antagonist of a G protein-coupled receptor to a subject in need of such treatment.

Abstract: We describe a plant and plant cell which is modified to enhance the production of plant-derived oil in particular in non-seed tissue and including methods for the processing of plant derived biomass materials.

Abstract: An operating system in a virtual environment can obtain the current time of the processor that the OS is utilizing through a method for synchronizing timers on multiple processors with a standard reference time, such as the Coordinated Universal Time (UTC). A hypervisor controlling the processors obtains a number of synchronization values that, together with a local timer counter value, are utilized by the guest operating system to determine the physical processor time.

Abstract: The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.

Abstract: This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.

Abstract: A waste storage device includes a container (21) in which a cassette (1) is mounted. Tubing (2) is pulled through the center of the cassette (1) to store packages (35) separated by twists. The cassette (1) is rotated relative to the container (21) to provide the twists between packages (35) by virtue of a rotatable disk (100) and user grip portion (102). The package is gripped against rotation by a gripper diaphragm (120) and is guided towards a wall of the container by a guide diaphragm (122) to prevent untwisting between packages.

Abstract: An architecture for resource management in a telecommunications network includes two or more nodes connected over a logically direct path in a peer-to-peer manner. At each node, local events typically trigger the node to transmit a broadcast to every other node. Broadcast information comprises a status of the local node's resources. Remote nodes receive the local node's broadcast and independently transmit their own broadcasts with similar information. Each node stores the received broadcast information in a local storage for future retrieval. When a session is desired with a remote node, the local node simply retrieves the remote node's resource status information from its local storage and determines if a session can occur. In this manner, every node of the network is aware of the nodal addresses of the other nodes, remote node's resource status, and can quickly retrieve, from its own local storage, the availability of the remote node's resources.

Abstract: This invention relates to nucleic acid molecules which comprise nucleic acid sequences which encode enzymes involved in the biosynthesis of n-3 fatty acids, particularly docosahexanoic acid (DHA), or variants thereof; polypeptides encoded by said nucleic acids; cells transfected with said nucleic acid sequences and products comprising said nucleic acid sequences, polypeptides and/or cells.

Abstract: This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.

Abstract: A system is described that includes a data warehouse and a platform independent data warehouse load application operable to run on the system. The load application includes a sequencing unit configured to utilize timestamp data from incoming data to be stored in the data warehouse and a relational algebra of set operators to identify and sequence net changes between the incoming data and data previously stored within the data warehouse. The load application is configured to non-intrusively load the identified and sequenced net changes into the data warehouse.

Abstract: The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.

Abstract: A gas turbine engine including a gas generator module and a reduction gearbox module. The gas generator module has an axis which extends longitudinally along a centreline of the gas generator module, and the reduction gearbox module has an axis which extending longitudinally along the centreline of the reduction gearbox and is offset from said generator axis. The reduction gearbox is driven by an intermediate shaft angled relative to the turbine output shaft.

Abstract: A method includes making coiled tubing at a coiled tubing manufacturing unit coupled to a coiled tubing transportation system. One or more coiled tubing reels are transported from the coiled tubing manufacturing unit to one or more moveable well drilling systems using the coiled tubing transportation system. The coiled tubing transportation system runs from the tubing manufacturing unit to one or more movable well drilling systems, and then back to the coiled tubing manufacturing unit.

Abstract: We describe a transgenic plant with altered expression of a gene that encodes a sequence variant of a transcription factor and which has altered seed dormancy.

Abstract: We describe a method for the detection of triacylglycerols (TAGs) in a biological sample.

Abstract: A vibration analysing device for determining the vibrational response of a structural element, comprising: a vibration sensor for providing an output in response to a force input imparted to the structural element; processing means adapted to determine one of a plurality of classifications in response to the output, each classification corresponding to a condition of the structural element; and display means for displaying the determined classification.

Abstract: A centrifuge (10) is provided with improved flying-lead mounting. The centrifuge comprises a cantilevered shaft (18) upon which the main drive rotor (26) is located. A bobbin (62) is attached to the planetary gear shaft (44), which is driven in planetary motion by the rotation of the rotor (26) and its toothed engagement with the shaft (18) of the cantilevered rotor. A flying lead section (72) extends from the bobbin (62) through an aperture in the cantilevered rotor (26) and is provided with a sheath or supporting tube(s) within which at least a portion of inlet and outlet leads are located.