Abstract: A networkable device is coupled to a wireless IP gateway or paired to a personal area network (PAN) via the use of a sonic tone, which may be a human audible tone, which encodes a symbol sequence representing a binary message useful for implementing connection to a wireless IP gateway or pairing with a PAN. In one embodiment the sonic tone conveys a media access controller (MAC) address, to facilitate connection and/or pairing. Alternatively, or in addition, the sonic tone may encode a Service Set Identifier (SSID) and password for connection to a wireless network (Wi-Fi), or a BLUETOOTH (IEEE 802.15.1) identifier and/or PIN for connection to a BLUETOOTH (IEEE 802.15.1) PAN. In particular implementation of this embodiment the tone is produced by the IP gateway and used to initiate Wi-Fi connection, and/or the tone is produced by the master device of a PAN to initiate BLUETOOTH (IEEE 802.15.1) connection.

Abstract: Display systems, such as near eye display systems or wearable heads up displays, may include a laser projection system having an optical engine and an optical scanner. Light output by the optical engine may be directed into the optical scanner as two angularly separated laser light beams. The angularly separated laser light beams may overlap at an entrance pupil plane along a first dimension at a first scan mirror of the optical scanner, or at a location between the first scan mirror and an optical relay of the optical scanner. The angularly separated laser light beams may overlap at an exit pupil plane along the first dimension at a second scan mirror of the optical scanner or at an incoupler of the laser projection system.

Abstract: A system includes one or more sensors one or more sensors configured to generate data associated with a sleep session of a user. The system also includes a multi-compartment bladder configured to be positioned adjacent to a user during the sleep session. The system also includes a memory storing machine-readable instructions. The system also includes a control system including one or more processors configured to execute the machine-readable instructions to determine, based at least in part on the generated data associated with the sleep session, that the user is experiencing or has experienced an event and responsive to determining that the user is experiencing or has experienced the event, cause the multi-compartment bladder to be modified to aid in causing the user to move.

Abstract: Systems, devices, and assemblies for implementing multi-focal lens portions in wearable heads-up displays are described. Multi-focal lens portions may include at least two regions having different optical power, and at least one transition region between regions having different optical power. If display light is directed through a transition region, aberrations or distortion may be visible in the display presented to the user. The present systems, devices, and assemblies address this issue through shaping, positioning, and orienting of regions of a multi-focal lens portion, through positioning, orientation, and aiming of display optics, and/or through arrangements of lens assemblies which prevent display light from travelling through a multi-focal lens portion.

Abstract: Systems and methods of separating the input light path from the output light path of a scanning mirror in a laser projector system while keeping the overall footprint of the laser projector system to a minimum. The system includes a scanning mirror, an optical engine, and an input/output (1/0) separator disposed between the optical engine and the scanning mirror to direct light from the optical engine towards the scanning mirror along an input path and to direct light reflected from the scanning mirror along an output path. The I/O separator, disposed to intersect both the input and output paths, can be implemented as a prism or a combination of a polarizing beam splitter and a quarter wave plate.

Abstract: A laser projection system utilizes a waveguide having a narrow incoupler for double-bounce mitigation and form factor reduction. An optical scanner includes an optical relay positioned in between two scan mirrors. The first scan mirror scans laser light into the optical relay in a first dimension, and the optical relay and converges the scanned laser light towards a second scan mirror. The second scan mirror scans laser light along a second dimension substantially perpendicular to a path over which the laser light is scanned across the second scan mirror, and the convergence introduced by the optical relay causes the laser light to be scanned as a line or arc path of an exit pupil plane that is coincident with the incoupler. The optical relay may include one or more lenses or may be a monolithic molded structure, which may be an Offner-style relay or a molded reflective relay.

Abstract: In a reclosable folding box (41, 42, 43) having a safety and tamper-evident closure (84), the side wall surfaces (2 to 6, 64, 65) of which are formed by a one-piece blank (1, 1a, 1b) and glued together in such a way that the folding box (41, 42, 43) cannot be opened without destroying a glued joint and/or at least one disconnectable tear line area (16, 17, 16a, 16b, 17a, 17b), a solution for a reclosable medical packaging having a safety and tamper-evident closure is to be created, which provides an improved graspability and visual recognizability of a pull tab forming at least the substantial part of the safety and tamper-evident closure.

Abstract: An optical element for implementation in a heads-up display or other near-eye display system includes a lightguide and an incoupler optically coupled to the lightguide. The incoupler receives a display beam incident upon the lightguide at a first incidence position. The incoupler directs a first portion of the display beam into the lightguide to form an incoupled beam and causes a second portion to remain non-incoupled relative to the lightguide to form a non-incoupled beam. The optical element further includes a reflector to receive the non-incoupled beam and to reflect the non-incoupled beam towards the incoupler to form a reflected beam incident upon the incoupler at a second incidence position. The incoupler direct a corresponding portion of the reflected beam into the lightguide to form a further incoupled beam.

Abstract: Methods and systems are for identifying the cell type of an unknown microorganism. The device includes: an apparatus for culturing unknown organism(s), a diagnostic data acquisition tool and a computer program. The method includes: incubation of the sample with a growth medium (with or without toxins), and an analysis of the metabolites detected in the sample. The computer system compares the results collected from the device to reference metabolite profiles.

Abstract: The present invention relates to dosing regimen of avelumab for the treatment of cancer. In particular, the invention relates to improved dosing regimen of avelumab for the treatment of cancer.

Abstract: The present disclosure provides compositions and methods capable of potentiating the effects of antibiotics against bacterial infections that either have developed, or that possess the potential to develop, antibiotic tolerance. Methods of sensitizing antibiotic tolerant bacteria to antibiotics, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at antibiotic tolerant bacteria are also provided.

Abstract: A head-mounted display system includes a head-mounted display unit and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use. The positioning and stabilising structure includes a rear support structure adapted to contact posterior regions of a user's head and a forehead support connector, which includes a forehead support strap, which extends generally along and in the direction of the sagittal plane and connects the rear support structure to a superior edge region of the head-mounted display unit. The forehead support connector further includes a forehead support rigidiser that provides rigidification to a portion of the forehead support connector.

Abstract: The present invention relates to dosing regimen of avelumab for the treatment of cancer. In particular, the invention relates to improved dosing regimen of avelumab for the treatment of cancer.

Abstract: An example programmable integrated circuit (IC) includes a processor, a plurality of endpoint circuits, a network-on-chip (NoC) having NoC master units (NMUs), NoC slave units (NSUs), NoC programmable switches (NPSs), a plurality of registers, and a NoC programming interface (NPI). The processor is coupled to the NPI and is configured to program the NPSs by loading an image to the registers through the NPI for providing physical channels between NMUs to the NSUs and providing data paths between the plurality of endpoint circuits.

Abstract: A head-mounted display system includes a head-mounted display unit and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use. The positioning and stabilising structure includes a rear support structure adapted to contact posterior regions of a user's head and opposing temporal connectors structured and arranged to interconnect the rear support structure to the head-mounted display unit, the opposing temporal connectors adapted to be disposed on opposing sides of the user's head and extend along the temporal regions of the user's head. At least the rear support structure comprises a textile material configured to conform to the posterior regions of the user's head.

Abstract: A system and method for provisionally authenticating a host moving from one router to another router in a network using border gateway protocol (BGP) is disclosed. A host is initially authenticated at a first BGP router, this discovery is advertised to a second BGP router pursuant to BGP with a new extended community indicating successful authentication (or pre-authentication) of the host at the first BGP router. An indication for re-authentication of the host at the second BGP router is then received, which blocks network traffic from the host to the second BGP router. Due to the notification of a previous authentication of the host, the second BGP router begins a provisional authentication session. In response to a successful completion of the provisional authentication session, the host is authorized to transmit network traffic on the second BGP router and subsequently blocked from doing the same at the first BGP router.

Abstract: A system and method for provisionally authenticating a host moving from a source port of a switch device to a destination port of the switch device is disclosed. The host is initially authenticated at the source port and blocked from forwarding network traffic at the destination port. During a provisional authentication session, an authentication agent executing on the switch intercepts one or more authentication packets sourced by the host and headed for the destination port of the switch device and redirects the authentication packets to an authentication server for validating the host at the destination port of the switch device. The switch device removes the block at the destination port in response to receiving an acknowledgment of successful authentication at the destination port from the authentication server.

Abstract: A head-mounted display system includes a head-mounted display unit and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use. The positioning and stabilising structure includes a rear support structure adapted to contact posterior regions of a user's head and at least one connector structured and arranged to interconnect the rear support structure to the head-mounted display unit. The rear support structure is in the form of a hoop comprising an occipital portion configured and arranged engage the user's head along a portion of the occipital bone adjacent a junction where the neck muscles attach to the occipital bone in use.

Abstract: A head-mounted display system includes a positioning and stabilising structure structured and arranged to hold a display unit in an operational position over a user's face in use and an interfacing structure for the display unit constructed and arranged to be in opposing relation with the user's face. The interfacing structure comprises a substantially continuous face engaging surface adapted to contact the user's face around a periphery of the user's eyes. The interfacing structure comprises silicone. The interfacing structure is configured and arranged such that force applied to the user's face is distributed around the periphery thereof. The interfacing structure comprises a first compliance at a first region and a second compliance at a second region, wherein the first region and the second region are configured around the periphery of the interfacing structure to allow selective distribution of the force onto the user's face.

Abstract: Antigen binding constructs that bind to CD8, as well as formulations and methods of using them, are described herein.