Abstract: The present invention relates to methods useful in the selection of cancer patients suitable for treatment with therapies directed at c-Met. The method employs imaging agents which comprise 18F-radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. Also disclosed are methods of treatment, methods of monitoring therapy directed atc-Met and the use of the imaging agents and peptides in the methods of the invention.

Abstract: Disclosed are apparatus and methods for providing images of memory objects. A computing device can receive a plurality of memory objects for one or more executable software components. The computing device can classify the plurality of memory objects in accord with a plurality of object classifications. A particular object classification can represent a probability that a memory object classified with the particular object classification is to be written to during execution of the one or more executable software components. The computing device can order the plurality of memory objects based on the plurality of object classifications. The computing device can provide an image for the one or more executable software components using the computing device, where the image includes the ordered plurality of memory objects.

Abstract: The present invention relates to methods for treating or preventing cancer and metastasis. More particularly, the present invention relates to methods for treating or preventing cancer by decreasing the expression and/or activity of Flightless I. Also provided are methods for inhibiting the growth of a cancerous cell and methods for inhibiting formation and/or growth of a tumor which also rely on decreasing the expression and/or activity of Flightless I. The present invention also extends to methods for diagnosing cancer, methods for determining if a subject is susceptible to developing cancer, and methods for assessing progression of cancer based on the finding that increased expression and/or activity of Flightless I is associated with cancer development, growth and metastasis. The present invention also provides methods for screening for a candidate therapeutic agent useful for treating or preventing cancer, and related pharmaceutical compositions and kits.

Abstract: A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: Disclosed are apparatus and methods for providing images of memory objects. A computing device can receive a plurality of memory objects for one or more executable software components. The computing device can classify the plurality of memory objects in accord with a plurality of object classifications. A particular object classification can represent a probability that a memory object classified with the particular object classification is to be written to during execution of the one or more executable software components. The computing device can order the plurality of memory objects based on the plurality of object classifications. The computing device can provide an image for the one or more executable software components using the computing device, where the image includes the ordered plurality of memory objects.

Abstract: A method of producing an ethylenically unsaturated carboxylic acid or ester such as (meth) acrylic acid or alkyl esters thereof, for example, methyl methacrylate is described. The process comprises the steps of contacting formaldehyde or a suitable source thereof with a carboxylic acid or ester, for example, propionic acid or alkyl esters thereof in the presence of a catalyst and optionally an alcohol. The catalyst comprises group II metal phosphate crystals having rod or needle like morphology or a suitable source thereof. The phosphate may be a hydroxyapatite, pyrophosphate, hydroxyphosphate, PO42? phosphate or mixtures thereof. The group II metal may be selected from Ca, Sr, Ba or mixtures thereof, for example, strontium hydroxyapatite and calcium hydroxyapatite. A catalyst system comprising a crystalline metal phosphate catalyst and a catalyst support is also described. The metal phosphate has rod/needle like morphology.

Abstract: A user interface method is disclosed. For a particular interface, such as a touch input device, the method involves defining an enablement protocol for a function and recording and retaining the enablement protocol of said function, such that a user enables the function by substantially reproducing the enablement protocol in the absence of spatial or temporal indication of at least a portion of the enablement protocol.

Abstract: A lithium ion battery pack includes a plurality of prismatic lithium polymer cells and one or more graphite heat spreaders. Each spreader has at least two major surfaces and is made of one of a sheet of a compressed mass of exfoliated graphite particles, a graphitized polyimide sheet, or combinations thereof.

Abstract: A test cell (10) for containing equipment (12) subject to pressure testing comprises a plurality of metal plate wall panels (14) and a mesh roof panel (16) formed from mesh strands (26) of a high strength material. Each wall panel has a lapped connection (18) with an adjacent wall panel. The mesh panel (16) may be formed from a ballistic fabric, and the mesh strands (26) may be wire, rope and braid of steel, metal, plastic, natural or composite fibre, or a combination thereof. In the event of a pressure failure of the equipment (12) under test, the roof panel (16) captures fragments of the equipment while allowing the dissipation of pressure shock waves through the apertures (28) in the mesh. The lapped connections (18) between wall panels (14) result in increased friction between adjacent wall panels (14) and thus an increase in the strength of the connection when subject to pressure shock waves.

Abstract: A user interface method is disclosed. For a particular interface, such as a touch input device, the method involves defining an enablement protocol for a function and recording and retaining the enablement protocol of said function, such that a user enables the function by substantially reproducing the enablement protocol in the absence of spatial or temporal indication of at least a portion of the enablement protocol.

Abstract: An interconnect for an integrated circuit communicating transactions between initiator Intellectual Property (IP) cores and multiple target IP cores coupled to the interconnect is generally described. The interconnect routes the transactions between the target IP cores and initiator IP cores in the integrated circuit. A first aggregate target of the target IP cores includes two or more memory channels that are interleaved in an address space for the first aggregate target in the address map. Each memory channel is divided up in defined memory interleave segments and then interleaved with memory interleave segments from other memory channels. An address map is divided up into two or more regions. Each interleaved memory interleave segment is assigned to at least one of those regions and populates the address space for that region, and parameters associated with the regions and memory interleave segments are configurable.

Abstract: Embodiments generally relate to an alignment device to assist in drilling or reaming an opening in a structure. The device comprises: a base element, the base element having at least one first fixation element to allow fixation of the device relative to the structure; a positioning element coupled to the base element, wherein a position of the positioning element relative to the base element is adjustable; an alignment element mounted to the positioning element and rotatable in at least two dimensions to allow precise alignment for a drilling or reaming tool with a drilling or reaming site on the structure; at least one second fixation element to allow fixation of the positioning element relative to the base element; and at least one third fixation element to allow fixation of the alignment element relative to the positioning element.

Abstract: This invention relates to lentiviral gene transfer vectors pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Abstract: Certain aspects of the present disclosure support a method and apparatus for fast frequency throttling and re-locking in a phase-locked loop (PLL) device. Aspects of the present disclosure present a method and apparatus for operating in an open loop control (OLC) mode of the PLL device for generating a periodic signal. During the OLC mode, clocking of circuitry interfaced with a digitally-controlled oscillator (DCO) of the PLL device can be disabled. A PLL output frequency associated with the periodic signal generated by the DCO can be controlled directly through a digital control word input into the DCO.

Abstract: A process for regenerating a silica-supported depleted alkali metal catalyst is described. The level of alkali metal on the depleted catalyst is at least 0.5 mol % and the silica support is a zero-gel. The process comprises the steps of contacting the silica supported depleted alkali metal catalyst with a solution of a salt of the alkali metal in a solvent system that has a polar organic solvent as the majority component. A re-impregnated catalyst prepared by the process of the invention any comprising a silica zero-gel support and a catalytic metal selected from an alkali metal in the range 0.5-5 mol % on the catalyst, wherein the surface area of the silica support is <180 m2/g is also described. The invention is applicable to a process for preparing an ethylenically unsaturated acid or ester comprising contacting an alkanoic acid or ester of the formula R1—CH2—COOR3, with formaldehyde or a suitable source of formaldehyde.

Abstract: A process for regenerating a silica-supported depleted alkali metal catalyst is described. The level of alkali metal on the depleted catalyst is at least 0.5 mol % and the silica support is a zero-gel. The process comprises the steps of contacting the silica supported depleted alkali metal catalyst with a solution of a salt of the alkali metal in a solvent system that has a polar organic solvent as the majority component. A re-impregnated catalyst prepared by the process of the invention any comprising a silica zero-gel support and a catalytic metal selected from an alkali metal in the range 0.5-5 mol % on the catalyst, wherein the surface area of the silica support is <180 m2/g is also described. The invention is applicable to a process for preparing an ethylenically unsaturated acid or ester comprising contacting an alkanoic acid or ester of the formula R1—CH2—COOR3, with formaldehyde or a suitable source of formaldehyde.

Abstract: A method, apparatus, and system are described, which generally relate to an integrated circuit having an interconnect that implements internal controls. The interconnect in an integrated circuit communicates transactions between initiator Intellectual Property (IP) cores and target IP cores coupled to the interconnect. The interconnect implements logic configured to support multiple transactions issued from a first initiator IP core to the multiple target IP cores while maintaining an expected execution order within the transactions. The logic supports a second transaction to be issued from the first initiator IP core to a second target IP core before a first transaction issued from the same first initiator IP core to a first target IP core has completed while ensuring that the first transaction completes before the second transaction and while ensuring an expected execution order within the first transaction and second transaction are maintained. The logic does not include any reorder buffering.

Abstract: A computing device can identify, for a placement of a label, a first and second character of the label that have a shortest distance from one another. The placement for the label can define a position at which the label is to be placed in an interactive geographic map and a formatting for that label. The computing device can determine that the first and second identified characters do not overlap. In response to determining that the first and second characters do not overlap, the computing device can select the placement of the label for display in the interactive geographic map.

Abstract: Disclosed are apparatus and methods for providing images of memory objects. A computing device can receive a plurality of memory objects for one or more executable software components. The computing device can classify the plurality of memory objects in accord with a plurality of object classifications. A particular object classification can represent a probability that a memory object classified with the particular object classification is to be written to during execution of the one or more executable software components. The computing device can order the plurality of memory objects based on the plurality of object classifications. The computing device can provide an image for the one or more executable software components using the computing device, where the image includes the ordered plurality of memory objects.

Abstract: The invention relates to a method of producing an ethylenically unsaturated carboxylic acid or ester, preferably an ?, ? ethylenically unsaturated carboxylic acid or ester. The method includes contacting formaldehyde or a suitable source thereof with a carboxylic acid or ester in the presence of a catalyst and optionally in the presence of an alcohol. The catalyst comprises a nitrided metal oxide having at least two types of metal cations, M1 and M2, wherein M1 is selected from the metals of group 2, 3, 4, 13 (called also IIIA) or 14 (called also IVA) of the periodic table and M2 is selected from the metals of groups 5 or 15 (called also VA) of the periodic table. The invention extends to a catalyst system.