Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death Ligand 1 receptor (PD-L1) and another therapeutic agent, and the use of the combination therapies for the treatment of cancer.

Abstract: Disclosed are apparatus and methods for providing images of memory objects. A computing device can receive a plurality of memory objects for one or more executable software components. The computing device can classify the plurality of memory objects in accord with a plurality of object classifications. A particular object classification can represent a probability that a memory object classified with the particular object classification is to be written to during execution of the one or more executable software components. The computing device can order the plurality of memory objects based on the plurality of object classifications. The computing device can provide an image for the one or more executable software components using the computing device, where the image includes the ordered plurality of memory objects.

Abstract: A catalyst has a modified silica support and comprises a modifier metal, zirconium and/or hafnium, and a catalytic metal on the modified support. The catalyst has at least a proportion, typically, at least 25%, of modifier metal present in moieties having a total of up to 2 modifier metal atoms. The moieties may be derived from a monomeric and/or dimeric cation source. A method of production:— provides a silica support with isolated silanol groups with optional treatment to provide isolated silanol groups (—SiOH) at a level of <2.5 groups per nm2; contacting the optionally treated silica support with a monomeric zirconium or hafnium modifier metal compound to effect adsorption onto the support; optionally calcining the modified support for a time and temperature sufficient to convert the monomeric zirconium or hafnium compound adsorbed on the surface to an oxide or hydroxide of zirconium or hafnium in preparation for catalyst impregnation.

Abstract: This invention relates to lentiviral gene transfer vectors pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Abstract: This invention relates to compositions, and methods of use thereof, for (i) enhancing executive cognitive function(s) (for example, decision making, planning, working memory, multitasking, judgment, numerical problem-solving, reading comprehension), and/or (ii) increasing blood flow in brain vasculature, comprising administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.

Abstract: A lithium ion battery pack includes a plurality of prismatic lithium polymer cells and one or more graphite heat spreaders. Each spreader has at least two major surfaces and is made of one of a sheet of a compressed mass of exfoliated graphite particles, a graphitized polyimide sheet, or combinations thereof.

Abstract: A pallet moulded from plastics material for supporting a flexible intermediate bulk container. It has a generally planar central panel portion, a pair of parallel inverted open channels extending across the pallet to form a respective pair of open-ended tunnels each tunnel having an upper wall and two side walls, and a pair of edge panel portions generally co-planar with the central panel. An array of raised elongate hump portions bulges upwards from the upper walls of the tunnels, each hump portion extending laterally across an upper wall. The two ends of the hump portions abut respective buttresses which extend up the side walls.

Abstract: Systems, devices, and methods for eyebox expansion in wearable heads-up displays (WHUD) are described. A WHUD includes a support structure, a scanning laser projector (SLP), a split mirror, an optical splitter, and a holographic combiner. When the WHUD is worn on the head of a user the holographic combiner is positioned in a field of view of the user. The SLP scans light signals onto the split mirror which reflects the light signals onto the optical splitter. The optical splitter redirects the light signals towards the holographic combiner such that subsets of the light signals originate from spatially-separated virtual positions. The holographic combiner redirects the light to the eye resulting in spatially-separated exit pupils. The spatial separation of the exit pupils results in an expanded eyebox. The indirect path of light from SLP to optical splitter enables a smaller and therefore more aesthetically desirable design for the WHUD.

Abstract: The present invention relates to dosing regimen of avelumab for the treatment of cancer. In particular, the invention relates to improved dosing regimen of avelumab for the treatment of cancer.

Abstract: This invention relates to compositions, and methods of use thereof, for (i) enhancing executive cognitive function(s) (for example, decision making, planning, working memory, multitasking, judgment, numerical problem-solving, reading comprehension), and/or (ii) increasing blood flow in brain vasculature, comprising administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.

Abstract: A hydrogen fueling system and method comprises a container, a first tank, second tank, and third tank disposed within the container, and a nozzle coupled to the second tank and the third tank. One or more computer-readable storage media storing instructions executable by one or more processors may control flow of liquid hydrogen and hydrogen gas in the system, adjust temperature of the tanks, control pressure in the tanks, and transfer hydrogen gas from the second tank, the third tank, or a combination thereof to one or more target vessels. The system may also comprise flow control assemblies and flow control valves to manage the transfer of liquid hydrogen and hydrogen gas in the system.

Abstract: A method of producing an ethylenically unsaturated carboxylic acid or ester, preferably an ?, ? ethylenically unsaturated carboxylic acid or ester. The method includes contacting formaldehyde or a suitable source thereof with a carboxylic acid or ester in the presence of a catalyst and optionally in the presence of an alcohol. The catalyst includes a nitrided metal oxide having at least two types of metal cations, M1 and M2, wherein M1 is selected from the metals of group 2, 3, 4, 13 (called also IIIA) or 14 (called also IVA) of the periodic table and M2 is selected from the metals of groups 5 or 15 (called also VA) of the periodic table.

Abstract: In a reclosable folding box (41, 42, 43) having a safety and tamper-evident closure (84), the side wall surfaces (2 to 6, 64, 65) of which are formed by a one-piece blank (1, 1a, 1b) and glued together in such a way that the folding box (41, 42, 43) cannot be opened without destroying a glued joint and/or at least one disconnectable tear line area (16, 17, 16a, 16b, 17a, 17b), a solution for a reclosable medical packaging having a safety and tamper-evident closure is to be created, which provides an improved graspability and visual recognizability of a pull tab forming at least the substantial part of the safety and tamper-evident closure.

Abstract: A machine learning model for predicting a size fit satisfaction for a variable size component is trained using at least sizing profiles of a plurality of items and feedbacks of subjects regarding sizing of the plurality of items. The machine learning model is used to determine a value for the variable size component that corresponds to an optimal predicted size fit satisfaction. The determined value of the variable size component is provided for use in creating a new item with a sizing variation based on the determined value.

Abstract: A turbomachine fan blade preform (10) comprising a pair of mutually opposing panels (12), and a membrane (20) sandwiched between the pair of panels (12). The membrane (20) is of a non-uniform thickness. The thickness of at least a portion of the membrane tapers along its length and/or width, between a relative thicker first region and relatively thinner second region.

Abstract: A process for regenerating a silica-supported depleted alkali metal catalyst is described. The level of alkali metal on the depleted catalyst is at least 0.5 mol % and the silica support is a zero-gel. The process comprises the steps of contacting the silica supported depleted alkali metal catalyst with a solution of a salt of the alkali metal in a solvent system that has a polar organic solvent as the majority component. A re-impregnated catalyst prepared by the process of the invention any comprising a silica zero-gel support and a catalytic metal selected from an alkali metal in the range 0.5-5 mol % on the catalyst, wherein the surface area of the silica support is <180 m2/g is also described. The invention is applicable to a process for preparing an ethylenically unsaturated acid or ester comprising contacting an alkanoic acid or ester of the formula R1—CH2—COOR3, with formaldehyde or a suitable source of formaldehyde.