Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: A furniture system has a longitudinally extending member (2), a component (4) comprising a mounting member (10) and a component mounting system for mounting the component (4) on the longitudinally extending member (2). The component mounting system includes a support member (7), a clamp member (11) and a fixing member (12). In use, the support member (7) is adapted to be located between the component (4) and the longitudinally extending member (2). The fixing member (12) extends through the clamp member (11) and the support member (7) to engage with the component mounting member (10). Engaging the fixing member (12) with the component mounting member (10) causes the clamp member (11) to engage with an engagement formation (24) on the longitudinally extending member (2) to clamp the support member (7) between the longitudinally extending member (2) and the component (4) to mount the component (4) on the longitudinally extending member (2).

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

Abstract: Described herein are techniques for generating a compiled shader program. The techniques include identifying input features of a shader program, providing the identified input features of the shader program to a trained model for selecting compiler operation values for shader programs, receiving, as output from the trained model, a compiler operation value for the shader program, and generating a compiled shader program based on the compiler operation value for execution on one or more compute units.

Abstract: The disclosure relates to compounds and compositions for sustained release of ocular therapeutics.

Abstract: The present disclosure provides intelligent lighting control systems.

Abstract: A multi-way circuit having a plurality of base modules may be used in multi-way schemes for lighting control devices. The multi-way circuit may operate with a controller and the base modules of a lighting control system to provide a fully functional, multi-way toggle circuit, even when the switches installed in the base module are not paired or in their off modes. The multi-way toggle circuit can be defined as follows: if any button in the circuit is pressed (indicating a desire to change the load state), then the load toggles its state between on and off.

Abstract: The invention relates to a liquid crystal mixture characterised in that it comprises one or more photoreactive mesogens of formula I wherein the parameters and groups occurring are defined as indicated in claim 1, to a process for the fabrication of liquid crystal displays using these liquid crystal mixtures and to a liquid crystal display obtainable by this process. The invention further relates to new compounds of formula I.

Abstract: The present invention relates to a transaction processing and method. A device associated with a payer, which may be a suitably adapted mobile telephone is involved in the payment transaction process. The transaction processing is information, such as goods to be purchased and amount, is provided from the payer electronic device to a transaction processing system. A transaction processing system then advises a payee (e.g. merchant) that goods have been ordered from the payee and provides the payee with the information on the ordered goods, and also confirms that payment has been made. The merchant subsequently provides the goods to the payer.

Abstract: At least one computer readable medium encoded with instructions that, when executed on a computer system, perform a method for determining one or more fluency characteristics of a writer from a piece of their prepared text and providing data to enable characterisation of the writer fluency. The method includes the steps of receiving text data carrying information on the piece of writing to be characterised; enumerating a set of sentences in the piece of writing, wherein each sentence is identified by applying a set of stored rules to the text data; determining a sentence type for each sentence within the piece of text by relating data carrying information on each sentence to stored rules and/or type data; aggregating a data set dependent on the sentence types identified and dependent on a defined aggregation operation; Characterisation data carrying information writer fluency measured dependent on the data set is generated.

Abstract: A computer-implemented method for advertisement placement. The method comprises (a) receiving a request of a media buyer to place an advertisement in a requested advertising slot associated with a media owner; (b) automatically determining whether the received request satisfies one or more booking rules to either accept or reject the request, wherein the booking rules are specified by the media owner and associated with the requested advertising slot; and (c) if the request is accepted, sending a request confirmation to the media buyer, but otherwise, determining an alternative advertising slot based on the rejected request and sending an offer of the alternative advertising slot to the media buyer. In other aspects, there are provided computer programs, a media owner system, a media buyer system, a computerized trading platform and a computer system for advertisement placement.

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: The invention relates to a method of manufacturing a liquid crystal display device wherein a liquid crystal mixture having positive dielectric anisotropy or negative dielectric anisotropy is interposed between a first substrate and a second substrate, the liquid crystal mixture comprising liquid crystal molecules, a self assembling photoalignment agent, a polymerisable compound, and wherein said LC mixture is photoaligned by irradiation with linearly polarised ultraviolet light and then cured by irradiation with ultraviolet light.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: To determine a location of a client device in a wireless network having at least first and second network devices, with known locations, one of the network devices transmits a message to the other network device and the other network device responds with an acknowledgement message. A client device receives the message and the acknowledgement message as well as respective times indicating actual times at which the message and the acknowledgement message were processed by one of the first and second network devices. The client device determines its location based on the times at which it received the message and the acknowledgement message and the difference between the actual processing times. This location may be refined by determining an angle between the client device and at least one of the network devices having multiple antennas and being configured for steered beam communications.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: The present invention discloses an adjuvant treatment of node-positive, early stage, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2?) breast cancer comprising administering an effective amount of an endocrine therapy in combination with an effective amount of abemaciclib or a pharmaceutically acceptable salt thereof.