Abstract: A compound of formula (I): for use in the prevention or treatment of a bacterial infection wherein: A is either S or Se; RA is selected from: wherein: each of Y1, Y2, Y3, Y4 and Y9 is independently selected from CH or N, wherein at least three of Y1, Y2, Y3, Y4 and Y9 is CH; V is selected from O, CH—OR01, N—CO2—RC2 or N—RN2; one of Y5, Y6, Y7 and Y8 is selected from CH and N, and the others are CH; X is selected from NH, S or O; RC1 is selected from O—RO2 or NHRN1; RO1 is selected from H and C1-3 unbranched alkyl; RO2 is C1-3 unbranched alkyl; RN1 is selected from H and C1-3 unbranched alkyl; RN2 is C1-3 unbranched alkyl; RC2 is either C1-3 unbranched alkyl or C3-4 branched alkyl; RC3 is selected from C1-3 unbranched alkyl and C2H4CO2H; RC4 is either H or Me; RC5 is either H or Me; RC6 represents one or two optional methyl substituents; and n is an integer from 2 to 8.

Abstract: A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein RP1 is either methyl, ethyl, isopropyl, cyclohexyl or phenyl; RP2 is selected from methyl, ethyl, isopropyl, cyclohexyl and phenyl; RP3 is either ethyl, isopropyl, cyclohexyl, phenyl or pyridyl; A is either S or Se; RA is selected from wherein each of Y1, Y2, Y3, Y4 and Y9 is independently selected from CH or N, wherein at least three of Y1, Y2, Y3, Y4 and Y9 are CH; V is selected from O, CH—ORO1, N—CO2—RC2 or N—RN2; one of V, Y6, Y7 and Y8 is selected from CH and N, and the others are CH; X is selected from NH, S or O; RC1 is selected from O—RO2 or NHRN1; RO1 is selected from H and C1-3 unbranched alkyl; RO2 is C1-3 unbranched alkyl; RN1 is selected from H and C1-3 unbranched alkyl; RN2 is C1-3 unbranched alkyl; RC2 is either C1-3 unbranched alkyl or C3-4 branched alkyl; RC3 is selected from C1-3 unbranched alkyl and C2H4CO2H; RC4 is either H or Me; RC5 is either H or Me; RC6 represents one or two optional methy

Abstract: An autoinjector including a housing, in which can be mounted a syringe having a plunger, a barrel and needle at one end thereof through which medicament can be delivered to an injection site; a syringe support means capable of causing said syringe to move therewith along an axial path with respect to said housing; biasing means capable of biasing said syringe support means so that said needle is normally inside said housing, blocking means selectively moveable by a user from a first position in which rearward movement of the syringe along said axial path is substantially prevented, to a second position in which rearward movement of the syringe along said axial path relative to said housing is possible and said biasing means causes said needle to retract inside said housing.

Abstract: A computer-implemented method for advertisement placement. The method comprises (a) receiving a request of a media buyer to place an advertisement in a requested advertising slot associated with a media owner; (b) automatically determining whether the received request satisfies one or more booking rules to either accept or reject the request, wherein the booking rules are specified by the media owner and associated with the requested advertising slot; and (c) if the request is accepted, sending a request confirmation to the media buyer, but otherwise, determining an alternative advertising slot based on the rejected request and sending an offer of the alternative advertising slot to the media buyer. In other aspects, there are provided computer programs, a media owner system, a media buyer system, a computerized trading platform and a computer system for advertisement placement.

Abstract: A multilayered circuit board having a metal-free region vertically extending through at least a portion of a conductive layer, which lies generally parallel to a horizontal plane, vertically spaced from an outer surface. Heat-emitting and heat-sensitive components are mounted on the outer surface. The heat-emitting component is vertically and laterally spaced from the metal-free region, whereas the heat-sensitive component is vertically spaced and laterally aligned within the metal-free region such that the metal-free region is a thermal barrier that shields heat-sensitive component from radial heat flowing from the heat-emitting component.

Abstract: The present invention relates to a transaction processing and method. A device associated with a payer, which may be a suitably adapted mobile telephone is involved in the payment transaction process. The transaction processing is information, such as goods to be purchased and amount, is provided from the payer electronic device to a transaction processing system. A transaction processing system then advises a payee (e.g. merchant) that goods have been ordered from the payee and provides the payee with the information on the ordered goods, and also confirms that payment has been made. The merchant subsequently provides the goods to the payer.

Abstract: The present invention relates to an electro-rheological fluid comprising particles of at least one inorganic or organic material suspended in a polar liquid crystalline medium, the use of such electro-rheological fluid in an haptic device, an haptic device itself, a method of the production of such haptic device and the use of such haptic device in electro-optical devices.

Abstract: Systems, methods, and devices for hazard detection are described. A hazard detection device may include a printed circuit board. The hazard detection device may further include a chassis that provides a housing for components of the hazard detection device; a smoke chamber that is mid-mounted; a carbon monoxide sensor that is mounted with the circuit board; and a speaker assembly that partially encircles the mid-mounted smoke chamber.

Abstract: A multilayered circuit board having a metal-free region vertically extending through at least a portion of a conductive layer, which lies generally parallel to a horizontal plane, vertically spaced from an outer surface. Heat-emitting and heat-sensitive components are mounted on the outer surface. The heat-emitting component is vertically and laterally spaced from the metal-free region, whereas the heat-sensitive component is vertically spaced and laterally aligned within the metal-free region such that the metal-free region is a thermal barrier that shields heat-sensitive component from radial heat flowing from the heat-emitting component.

Abstract: Systems, methods, and devices are included for providing hazard detection. For example, a hazard detection device may include a printed circuit board. The hazard detection device may further include a chassis that provides a housing for components of the hazard detection device; a smoke chamber that at least partially houses a photoelectric diode; a carbon monoxide sensor that at least partially encased in a metallic covering; a first wireless interface component that comprising a first radio antenna configured to transmit and receive data according to a first wireless communication protocol; and a second wireless interface component that comprises a second radio antenna configured to transmit and receive data using a second wireless communication protocol.

Abstract: This disclosure is directed to a test fixture to test a robustness of a connection port of an electronic device, a cable connector coupled to the connection port, or both. The test fixture may enable repeatable testing using predetermined test parameters. The test fixture may secure the electronic device using a clamp. A pendulum may be mounted in the test fixture and rotatable to cause an impact of a weight against a cable connector coupled to the connection port of an electronic device. After the impact, the integrity and/or functionality of the cable connector, the connection port, or both may be inspected. In accordance with one or more embodiments, the test fixture may be under at least partial control of a controller. The controller may enable creation or control of test parameters, repeat testing, cycle testing, and/or inspection (e.g., determining whether the connection is maintained and/or functional, etc.).

Abstract: A human-powered positive-displacement single dual-action cylinder treadle pump for use in pumping and distributing water from wells and other water sources, as well as methods of manufacturing and operating such a pump. The pump offers rural farmers a portable device for pumping water for use in irrigating fields and crops that is powerful, low-cost, modular and portable. The modularity of the pump allows for easy access to any of the components of the pump should they require maintenance, repair or replacement.

Abstract: The invention relates to a flexible coupling comprising a lower assembly (10) having a spigot member (20), and an upper assembly (60) having a recess adapted to receive the spigot member, thereby allowing articulation of the upper assembly (60) with respect to the lower assembly (10) in any direction. A complementary indexing means is adapted to circumferentially align the lower assembly (10) and the upper assembly (60), and a single resilient member (65) interconnects the lower and upper assemblies, wherein the lower and upper assemblies are urged into mutual engagement against said articulation.

Abstract: The present invention relates to a transaction processing and method. A device associated with a payer, which may be a suitably adapted mobile telephone is involved in the payment transaction process. The transaction processing is information, such as goods to be purchased and amount, is provided from the payer electronic device to a transaction processing system. A transaction processing system then advises a payee (e.g. merchant) that goods have been ordered from the payee and provides the payee with the information on the ordered goods, and also confirms that payment has been made. The merchant subsequently provides the goods to the payer.

Abstract: Spinal rod approximator for seating a stabilizing rod in a rod-receiving portion of a spinal implant and inserting closure mechanism is provided. In one embodiment, a spinal rod approximator is provided including a body with gripping branches, inserter shaft, threaded collar, and outer sleeve.

Abstract: The present invention relates to a transaction processing and method. A device associated with a payer, which may be a suitably adapted mobile telephone is involved in the payment transaction process. The transaction processing is information, such as goods to be purchased and amount, is provided from the payer electronic device to a transaction processing system. A transaction processing system then advises a payee (e.g. merchant) that goods have been ordered from the payee and provides the payee with the information on the ordered goods, and also confirms that payment has been made. The merchant subsequently provides the goods to the payer.

Abstract: A human-powered positive-displacement single dual-action cylinder treadle pump for use in pumping and distributing water from wells and other water sources, as well as methods of manufacturing and operating such a pump. The pump offers rural farmers a portable device for pumping water for use in irrigating fields and crops that is powerful, low-cost, modular and portable. The modularity of the pump allows for easy access to any of the components of the pump should they require maintenance, repair or replacement.

Abstract: The present invention relates to a transaction processing and method. A device associated with a payer, which may be a suitably adapted mobile telephone is involved in the payment transaction process. The transaction processing is information, such as goods to be purchased and amount, is provided from the payer electronic device to a transaction processing system. A transaction processing system then advises a payee (e.g. merchant) that goods have been ordered from the payee and provides the payee with the information on the ordered goods, and also confirms that payment has been made. The merchant subsequently provides the goods to the payer.

Abstract: To determine a location of a client device in a wireless network having at least first and second network devices, with known locations, one of the network devices transmits a message to the other network device and the other network device responds with an acknowledgement message. A client device receives the message and the acknowledgement message as well as respective times indicating actual times at which the message and the acknowledgement message were processed by one of the first and second network devices. The client device determines its location based on the times at which it received the message and the acknowledgement message and the difference between the actual processing times. This location may be refined by determining an angle between the client device and at least one of the network devices having multiple antennas and being configured for steered beam communications.

Abstract: An autoinjector comprising an outer housing in which can be mounted a syringe for holding a volume of medicament, the syringe for holding medicament having a needle at one end thereof, a syringe holder for supporting the syringe in an axial position relative to the outer housing, and an intermediate housing at least part of which is located within said outer housing, characterised in that said intermediate housing is provided with a blocking means capable of abutting the syringe or the syringe holder so as to be capable of preventing forward axial movement of the syringe when a forward axial force is applied to said needle before actuation of the autoinjector to deliver an injection, but incapable of preventing forward axial movement of the syringe during actuation of the autoinjector to deliver an injection.