Abstract: The present disclosure relates to systems, methods, and computer-readable media for determining instances of parity drift in target cloud computing systems as well as determining when instances of parity drift require addressing. For example, in various implementations, a cloud parity drift detection system compiles information about services, configurations, versions, etc. along with additional data from a reference cloud system into a job package and provides the job package to one or more target cloud computing systems. The cloud parity drift detection system can then utilize the job package to compare corresponding information on the reference cloud system to a target data set of the target cloud system to determine instances of parity drift at the target cloud system. Additionally, the cloud parity drift detection system can determine and act when instances of parity drift require addressing.

Abstract: Apparatuses, systems, and methods for compensated sense amplifier with crosscoupled n-type transistors. A sense amplifier has a pair of p-type transistors coupled between a system voltage and respective first and second gut nodes. When a command signal is active, the p-type transistors are coupled in a diode fashion from the system voltage to the respective gut nodes. The amplifier also has a pair of n-type transistors which are cross coupled, where a first n-type transistor has a node coupled to the first gut node and a gate coupled to the second gut node and the second n-type transistor has a node coupled to the second gut node and a gate coupled to the first gut node. Each of the n-type transistors may have a separate current flowing through them and respective one of a pair of feedback transistors to a ground voltage.

Abstract: A sense amplifier can be formed outside of/horizontally adjacent to an array of vertically stacked tiers of memory cells. Memory cells can be sensed via multiplexors formed under the array that can operate to couple vertical sense lines (to which the memory cells are coupled) to horizontal sense lines (to which the sense amplifier is coupled).

Abstract: The disclosure provides methods for detecting a RAS pathway mutation in a subject. The methods include obtaining a biological sample from the subject, isolating nucleic acids from the biological sample, and analyzing the expression level of noncoding RNAs in the nucleic acids in conjunction with a corresponding reference level in a control sample, wherein a differential expression level of the noncoding RNAs compared to the corresponding reference level in the control sample indicates that the subject has a RAS pathway mutation.

Abstract: The present invention provides novel full-length human antibodies that bind to human Fc epsilon-R1 alpha (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both Fc epsilon-R1 alpha and CD3 and activate T cells via the CD3 complex in the presence of Fc epsilon-R1 alpha-expressing cells. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced Fc epsilon-R1 alpha-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of allergies, including anaphylaxis.

Abstract: Systems and methods according to present principles meet the needs of the above in several ways, and in particular provide a product that can continuously monitor and remove air from the stomach without removing liquid from a premature neonate's stomach. The device works by providing suction pressure of, e.g., 10±0.1 mmHg through the feeding tube to continuously remove air from the stomach. In this way the device prevents the problem of gastric distension all together. The pressure may be regulated by using an electronic control valve.

Abstract: The present disclosure relates to molecules capable of binding to both CD20 and PD1, as well as pharmaceutical compositions comprising such molecules and methods of use thereof.

Abstract: In some implementations, a computing device can guide a user of the computing device through creation of media content using storyboard templates. For example, the user may invoke a media editing application on the computing device. The media editing application can be configured with a plurality of different storyboard templates to be used for the creation of different types or categories of content. A storyboard template corresponding to a particular type of content can include suggested media segments and suggested media clips for the particular type, or topic, of content. Thus, a particular storyboard template can include suggested media segments and suggested media clips that are different from other storyboard templates. The media editing application can include features that allow the user to edit the storyboard template and/or the media content corresponding to a storyboard project created by the user.

Abstract: A memory array comprising strings of memory cells comprises a vertical stack comprising alternating insulative tiers and conductive tiers. The strings of memory cells in the stack comprise channel-material strings and storage-material strings extending through the insulative tiers and the conductive tiers. At least some of the storage material of the storage-material strings in individual of the insulative tiers are intrinsically less charge-transmissive than is the storage material in the storage-material strings in individual of the conductive tiers. Other aspects, including method, are disclosed.

Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

Abstract: Methods and systems for managing inventory at a retail facility include an image capture device having a field of view that includes a product display shelf of the retail facility, an electronic database that stores a planogram of product display shelves at the retail facility and a computing device. The computing device obtains an image of a product display shelf, detects the individual packages of each of the different products captured in the image, defines different product display areas for the different products on the product display shelf captured in the image, and generates virtual boundary lines that surround each of the defined product display areas. The computing device also determines an identity of a product contained located in each defined product display area, and associates the virtual boundary lines surrounding each defined product display area with an identifier unique to the product contained in the defined product display area.

Abstract: Providing access to an external application includes receiving login credentials to access a client instance, wherein the login credentials are associated with a user account, causing the client instance to provide a link to an external application in the client instance, detecting a request to navigate to the external application from the link, generating a authentication record for the user account and the external application, storing information for the user account based on the authentication record, and generating a URL for the external application based on the authentication record. Providing access to the external application also includes receiving, from a remote client device hosting the external application, an authorization request comprising nonce information, determining that the user account is authorized to access the external application based on the authentication table, and providing access to the external application.

Abstract: A FX phase driver for a memory device having a first driver circuit including a first pull-up circuit configured to drive a first phase signal to a first high state value and a first pull-down circuit configured to drive the first phase signal to a first low state value. The phase driver also including a second driver circuit including a second pull-up circuit configured to drive a second phase signal to a second high state value that is higher than an active state voltage level of a word line in the memory device and a second pull-down circuit configured to drive the second phase signal to a second low state value. The second pull-down circuit includes a stabilization circuit configured to provide a resistive path for a leakage current in the second pull-down circuit when the second pull-up circuit drives the second phase signal to the second high state value.

Abstract: Disclosed here are metal coils conjugated to TGF-beta ligand(s) or TGF-beta activator(s) to improve the outcome of existing surgical treatments on intracranial aneurysm patients and methods for using the same.

Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.

Abstract: Disclosed here are uses of anti-podosome therapies for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that endothelial podosomes plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.