Abstract: Devices, methods and systems are provided for occluding a left atrial appendage. In one embodiment, a medical device includes a cover portion and a foam anchor portion with a flexible member coupled therebetween. The cover portion is configured to be positioned over an ostium of the left atrial appendage. The foam anchor portion extends between a proximal end and a distal end to define a length and an axis defined along the length of the foam anchor portion. The foam anchor portion defines a curved external surface radially extending relative to the axis such that the curved external surface extends between the proximal and distal ends of the foam anchor portion. The foam anchor portion is configured to self-expand to provide an outward biasing force from the curved external surface such that a circumferential surface area of the curved external surface biases against tissue of the left atrial appendage.

Abstract: Embodiments of golf club heads having adjustable weighting systems with a plurality of discrete attachment locations capable of receiving one or more weights are described herein. The golf club heads described herein provide user adjustability of club head center of gravity to adjust ball flight while maintaining a high moment of inertia and low and back center of gravity position.

Abstract: A vehicle, system, and method provide determining whether a thermal risk exists for an occupant of a passenger compartment of a vehicle based on: identifying, via the temperature sensor, that the temperature within the passenger compartment is outside of a safe temperature range, identifying, via an electronic control module, that an engine of the vehicle is not running, and identifying, via the occupant sensor, that an occupant is in the passenger compartment. In response to determining that the thermal risk exists, a controller starts starting the engine via an ignition locking system, closes power-actuated windows of the passenger compartment, locks power-locked doors of the passenger compartment, and activates a heating, ventilation and air conditioning system of the vehicle via a climate control unit. The HVAC maintains the temperature of the passenger compartment within the safe temperature range to safeguard the occupant until return of a responsible party.

Abstract: Disclosed herein are methods and compositions for inactivating MHC genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart are provided. In one embodiment, the medical device includes an occluder portion and an anchor portion that are pivotably coupled to each other with hinge components. The hinge components each include a base with arms extending from the base such that the arms of each one of the hinge components extend through and capture a first eyelet of the occluder portion and a second eyelet of the anchor portion to facilitate pivotably coupling the anchor portion to the occluder portion.

Abstract: Compositions are provided including an uncrosslinked thermoplastic nitrogen-containing matrix material and composite particles distributed in the matrix material. The composite particles each include a chemical blowing agent particle encapsulated within a shell including an uncrosslinked thermoplastic material. The uncrosslinked thermoplastic material exhibits at least a certain minimum complex viscosity at a decomposition temperature of the chemical blowing agent particle. Also described are foam compositions and particles including the foam compositions, such as a sheet or multilayer construction. Composite particles are further provided. Methods of making the foam compositions are additionally described herein. Also, polishing pads, polishing systems, and methods of polishing a substrate are provided.

Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.

Abstract: A radio frequency (RF) communications system may include an RF transmitter having multicarrier transmitter circuitry that transmits frequency bands over a frequency range. A controller may selectively transmit real information over at least one of the frequency bands and selectively transmits fake information within the frequency range. The controller's operation is based on embedded machine learning model and real-time effectiveness feedback from built-in spectral analyzer. An RF receiver receives the real information from the RF transmitter.

Abstract: Certain aspects of the present disclosure provide techniques for maintaining an application through an execution platform. An example method generally includes receiving a first workflow definition of a plurality of workflow definitions associated with an application. The first workflow definition may be a workflow defining a build operation for building the application. The first workflow definition is executed to build the application by retrieving an executable binary from a binary repository, retrieving source code for the application binary from an application source code repository, building the application binary by executing the executable binary on the retrieved source code, and storing the application binary in the binary repository. A second workflow definition is received to execute the application. The second workflow is executed to execute the application by retrieving the application binary from the binary repository, and executing the retrieved application binary to run the application.

Abstract: An ultrasonic transducer and generator (TAG) assembly of a surgical instrument includes generator components and transducer components. The generator components are disposed within a first cavity cooperatively defined by a body portion and a cover. The generator components are covered in a thermally insulative material. The transducer components are disposed within a second cavity cooperatively defined by a proximal housing and a spinner housing.

Abstract: An optical connector assembly (100) includes a housing (110), an optical ferrule (140); and an optical fiber array (150). The housing (110) has a mating end (111) and an opposite cable end (112) and includes: a first housing portion (120) including a front support (122) proximate the mating end (111) and a rear support (124) disposed between the front support (122) and the cable end (112); and a second housing portion (130) assembled to the first housing portion (120) and including a middle support (133) disposed between the front and rear supports (122,124). The ferrule (140) is supported by the front support (122). Front ends of optical fibers of the optical fiber array (150) are received by and attached to an attachment area of the ferrule (140). When the second housing portion (130) is assembled to the first housing portion (120), the middle support (133) of the second housing portion (130) contacts and bends the optical fiber array (150) about the middle support (133).

Abstract: An apparatus for disrupting tissue in the intervertebral disc space that includes a barrier member having a first configuration for insertion into the disc space and a second configuration when deployed within the disc space. The second configuration of the barrier member is adapted to at least partially define a perimeter of a working region within the disc space. The apparatus also includes a tissue disruption tool configured for insertion into the working region.

Abstract: A method includes receiving first metrics describing first behaviors of applications having a fault, and second metrics describing second behaviors of an enterprise system in which the applications are executing. The first and second metrics are ingested. Ingesting includes assigning a first cardinality score to first metrics related to the fault. Ingesting also includes assigning a second, lower cardinality score to second metrics that are unrelated to the fault. Tumbling window processing is performed on the ingested metrics by sorting the first metrics and the second metrics into time slices. Each of the time slices includes a corresponding data structure for storing the data in the different time periods. Tumbling window processing is also performed on the ingested metrics by storing more data in the time slices for the first metrics having the first cardinality score relative to the second metrics having the second cardinality score.

Abstract: Embodiments of golf club heads having adjustable weighting systems with a plurality of discrete attachment locations capable of receiving one or more weights are described herein. The golf club heads described herein provide user adjustability of club head center of gravity to adjust ball flight while maintaining a high moment of inertia and low and back center of gravity position.

Abstract: Disclosed herein are methods and compositions for inactivating MEW genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

Abstract: A system including a data repository storing metrics describing operational behavior of software programs executing in an enterprise system. The system also includes an application programming interface (API) gateway configured to receive the metrics. The system also includes an ingestion layer configured to ingest the metrics to form the ingested metrics. The system also includes a tumbling window processor configured to process the ingested metrics and the events into heat maps, sort the heat maps into the time slices, and populate the time slices with the ingested metrics.

Abstract: Analyte-insensitive materials comprising polymerizable monomers suitable for use in forming a hydrophilic, cross-linked gel comprising on the surface of a substrate for an electrode.

Abstract: An apparatus for disrupting tissue in the intervertebral disc space that includes a barrier member having a first configuration for insertion into the disc space and a second configuration when deployed within the disc space. The second configuration of the barrier member is adapted to at least partially define a perimeter of a working region within the disc space. The apparatus also includes a tissue disruption tool configured for insertion into the working region.