Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: First account information associated with a media delivery platform account is associated with second account information associated a third-party service provider account. Both the media delivery platform account and the third-party service provider account are associated with a particular consumer, and the first account information includes information indicating whether insertion of converted text-based notifications are enabled for a particular broadcast media stream. A text-based notification, which originates from the third-party service provider account and is directed to the particular consumer, is received. In response to determining, based on the first account information, that insertion of converted text-based notifications is enabled for the particular broadcast media stream: 1) the text-based notification into a converted text-based notification including personalized audio content; and 2) the converted-text-based notification is inserted into the particular broadcast media stream.

Abstract: A method for execution by one or more computing devices includes receiving, by a mobile device, a mobile device instance of a customized station. The method further includes initiating playback of the customized station via the mobile device. The method further includes automatically synchronizing the mobile device instance of the customized station with a non-mobile device instance of the customized station in accordance with synchronization settings associated with the customized station to produce a synchronized mobile device instance of the customized station and a synchronized non-mobile device instance of the customized station, where when the synchronized mobile device instance is switched to the synchronized non-mobile device instance, the playback of the customized station from the synchronized mobile device instance continues uninterrupted via the synchronized non-mobile device instance.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: A first server controls insertion of media content into a media stream, and transmits the media stream from the first server to a media player. The first server also transmits, to a second server, information linking a particular consumer to both a third-party service and to the media player. Control of inserting media content into the media stream is passed from the first server to the second server. The second server receives consumer-specific content associated with the particular consumer from the third-party service, and maps the consumer-specific content to the media player based, at least in part, on the information linking the particular consumer to both the third-party service and to the media player. The second server then inserts the consumer-specific content into the media stream during a time period the second server is in control of inserting media content into the media stream.

Abstract: A user of a mobile device can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel received by the mobile device. The user can customize the station so that wherever the user is currently located, they can receive on their mobile device perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize original content from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A processing device implementing a streaming media service determines that a user has logged-in to the streaming media service, and retrieves, from a storage device, a user-specified location preference. The user-specified location preference indicates that a user has selected between receiving perishable content associated with a specified static location and perishable content associated with a current user location. a processing device included in a media delivery platform, obtains perishable content items selected in accordance with the user-specified location preference, assembles the perishable content items into an add-in block, and delivers the add-in block to the streaming media service. The streaming media service inserts the add-in block into a media stream associated with the user, and delivers the media stream to a user device.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: A first server controls insertion of media content into a media stream, and transmits the media stream from the first server to a media player. The first server also transmits, to a second server, information linking a particular consumer to both a third-party service and to the media player. Control of inserting media content into the media stream is passed from the first server to the second server. The second server receives consumer-specific content associated with the particular consumer from the third-party service, and maps the consumer-specific content to the media player based, at least in part, on the information linking the particular consumer to both the third-party service and to the media player. The second server then inserts the consumer-specific content into the media stream during a time period the second server is in control of inserting media content into the media stream.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: A media automation system generates multiple instances of a media broadcast stream, which includes core content common to each of the instances of the media broadcast stream, and multiple spot blocks interspersed within the media broadcast stream. Each stream instance is associated with a particular media playout device. A user notification is received and a packaged user notification is generated for inclusion in a particular instance of the media broadcast stream. Packaging the user notification includes obtaining first account information associated with a media delivery platform account of a user associated with a particular media playout device, and second account information associated with a consumer notification service account of the user. The user notification is mapped to the particular media playout device based on the first and second account information, and the packaged user notification is inserted into a first available spot block of the particular instance of the media broadcast stream.

Abstract: A user of a mobile device can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel received by the mobile device. The user can customize the station so that wherever the user is currently located, they can receive on their mobile device perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize original content from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.