Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: A method of allowing listeners to participate in broadcast programming is provided, the method generally comprising one or more of providing a library of media elements accessible by a plurality of listeners; receiving from each of at least two of the listeners a playlist of media elements, wherein at least one of the media elements in each playlist is from the library of media elements; editing the playlists using broadcast scheduling software; providing the edited playlists to the plurality of listeners for playback, and for feedback regarding the playlists; and receiving feedback from at least one of the listeners regarding the playlists. A system and apparatus are similarly provided.

Abstract: A live media broadcast includes core content streamed to multiple users. While all consumers can be presented with the same core content, each individual consumer can be provided with individually customized content from various notification services during commercial breaks. For example, while one consumer can be provided with customized banking updates from her bank account during part of a commercial break, during that same commercial break another user might be provided with social media notifications or reminders from his calendar. Notifications or updates can be received in a text format and converted to an audio or other suitable format at an ad server, and delivered to a media automation system for insertion into a media stream in a way that integrates notifications into the listening or viewing experience without interrupting presentation of the core content.

Abstract: A media receiver identifies attributes of a media station to which the media receiver is currently tuned. The media receiver monitors the signal quality of the media station. If the signal quality of the media station drops below a quality threshold, the receiver chooses an alternate station having similar content, and then tunes to the alternate station until the signal quality of the original station improves. When the signal quality of the original station rises above a re-tune threshold, the receiver can switch back to the original station. The receiver can monitor and record user listening patterns, station-switching patterns, and situational parameters, to identify times or locations at which station switches occur. This information can be used to select appropriate alternative stations, to perform pre-emptive station switches, and to determine when a station's content will be buffered with the expectation that a station's signal will drop below the quality threshold.

Abstract: A radio receiver may comprise a receiver adaptable for receiving a plurality of broadcast streams over a plurality of broadcast channels, wherein the receiver will attempt to receive a selected broadcast stream on a selected broadcast channel, and if the selected broadcast stream is not receivable on the selected broadcast channel, the receiver will attempt to receive the selected broadcast stream on an alternative broadcast channel. A computer readable medium may allow a user of a receiver to create a composite stream comprising at least one portion selected from each of at least two of a plurality of broadcast streams. A method of open interface merge replication may involve comparing data between first and second databases, and if a conflict exists, updating one of the first and second databases with at least a portion of data from the other of the first and second databases to resolve the conflict.

Abstract: A user can specify particular news weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A radio receiver may comprise a receiver adaptable for receiving a plurality of broadcast streams over a plurality of broadcast channels, wherein the receiver will attempt to receive a selected broadcast stream on a selected broadcast channel, and if the selected broadcast stream is not receivable on the selected broadcast channel, the receiver will attempt to receive the selected broadcast stream on an alternative broadcast channel. A computer readable medium may allow a user of a receiver to create a composite stream comprising at least one portion selected from each of at least two of a plurality of broadcast streams. A method of open interface merge replication may involve comparing data between first and second databases, and if a conflict exists, updating one of the first and second databases with at least a portion of data from the other of the first and second databases to resolve the conflict.

Abstract: A system and method for providing a radio-like experience may comprise providing a personal media library (PML)-based playlist, including receiving media elements from a listener's PML, creating a playlist of the media elements using professional broadcast scheduling software and providing the playlist to the listener. A system and method of providing a radio-like experience may also comprise creating a playlist of media elements according to the user preferences for a media genre and for perishable content and providing the playlist to the listener. A method of distributing user-generated content may comprise incorporating user-generated content into a playlist of media elements according to the listener preference and providing the playlist to the listener. A method of distributing user generated content may also comprise receiving user-generated content, incorporating the user-generated content into a playlist of media elements of the recipient and providing the playlist to the recipient.

Abstract: A method of creating a dynamic audio file may comprise associating a tag with an audio file having audio content and the tag may comprise a location file path of a source of the audio content. A method of updating a dynamic audio file may comprise sending a dynamic audio file, receiving a request for updated audio content, and sending the updated audio content in response to the request. In various embodiments, the dynamic audio file may comprise a tag and initial audio content and the tag may comprise a location file path of the audio content.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: An apparatus for manufacturing strengthened glass containers, and more particularly the construction and operation of a bottom cooler in an apparatus for thermally strengthening glass containers in a glass container manufacturing line at a location intermediate the hot end and the cold end. Glass containers formed at an I.S. machine are conveyed through a special tempering Lehr that heats them uniformly to a high temperature that is short of temperatures at which they may become deformed. Subsequently, the glass containers are rapidly thermally strengthened in a cooling station in which the outer and inner surfaces including all areas of the glass containers are simultaneously cooled to a temperature below the Strain Point of the glass used in the glass containers, with the bottom coolers being used to cool the bottoms of the glass containers.

Abstract: Media consumers can elect to have local news, weather, traffic, or other perishable content inserted into customized media streams. The perishable content is inserted into the media stream as an add-in block containing items associated with a particular locale that matches a user location source preference. The user can specify a static location source preference, or a follow-me, or roaming preference, in which the user's current location is used. The perishable content is selected for inclusion in an add-in block by matching a user's location preference to a locale associated with the perishable content.

Abstract: Provided is a method of monitoring the treatment of Gaucher disease with specific pharmacological chaperones using systemic and/or cellular surrogate markers. Also provided is a new biomarker that may be used to monitor the progress of such treatment.

Abstract: A listener participation interface allows listeners to generate playlists that include media elements selected from a library of available media elements. The playlists generated by the listener participation interface are automatically compatible with broadcast automation software used by a broadcaster, so that little, if any, modification of listener-submitted playlists is required before the broadcast automation software incorporates the playlists into an actual broadcast schedule.

Abstract: The method for modeling a dosing regimen for a medicament includes providing a system having at least two biocompartments. The method determines steady state levels in each of the biocompartments. After that, the method provides for modifying values to calculate an amount of at least one protein in one of the biocompartments to which the protein is being transported. Next, the method calculates and integrates a weighted value of the protein to find a weighted area under the curve. Then, the method calculates and integrates a non-drug value of the protein to find a non-drug area under the curve. Finally, the method evaluates one or more dosing regimens by comparing the weighted area under the curve and the non-drug area under the curve of the protein to determine a net effect of the drug over the time period.

Abstract: A radio receiver may comprise a receiver adaptable for receiving a plurality of broadcast streams over a plurality of broadcast channels, wherein the receiver will attempt to receive a selected broadcast stream on a selected broadcast channel, and if the selected broadcast stream is not receivable on the selected broadcast channel, the receiver will attempt to receive the selected broadcast stream on an alternative broadcast channel. A computer readable medium may allow a user of a receiver to create a composite stream comprising at least one portion selected from each of at least two of a plurality of broadcast streams. A method of open interface merge replication may involve comparing data between first and second databases, and if a conflict exists, updating one of the first and second databases with at least a portion of data from the other of the first and second databases to resolve the conflict.

Abstract: A radio receiver may comprise a receiver adaptable for receiving a plurality of broadcast streams over a plurality of broadcast channels, wherein the receiver will attempt to receive a selected broadcast stream on a selected broadcast channel, and if the selected broadcast stream is not receivable on the selected broadcast channel, the receiver will attempt to receive the selected broadcast stream on an alternative broadcast channel. A computer readable medium may allow a user of a receiver to create a composite stream comprising at least one portion selected from each of at least two of a plurality of broadcast streams. A method of open interface merge replication may involve comparing data between first and second databases, and if a conflict exists, updating one of the first and second databases with at least a portion of data from the other of the first and second databases to resolve the conflict.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.