Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize original content from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A method for time-sensitive data files in continuously generated data streams by a server computer comprises receiving user profile information associated with a plurality of different users and generating a dynamic data file that includes a plurality of user-selected metadata attributes, including a source link address to link with content via a universal resource locator file path. The method continues with the server computer receiving a request for a continuous data stream, generating the continuous data stream, inserting the dynamic data file in the continuous data stream and transmitting different content to a computing device associated with each of the plurality of different users.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A processing device implementing a streaming media service determines that a user has logged-in to the streaming media service, and retrieves, from a storage device, a user-specified location preference. The user-specified location preference indicates that a user has selected between receiving perishable content associated with a specified static location and perishable content associated with a current user location. a processing device included in a media delivery platform, obtains perishable content items selected in accordance with the user-specified location preference, assembles the perishable content items into an add-in block, and delivers the add-in block to the streaming media service. The streaming media service inserts the add-in block into a media stream associated with the user, and delivers the media stream to a user device.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: Media consumers can elect to have local news, weather, traffic, or other perishable content inserted into customized media streams. The perishable content is inserted into the media stream as an add-in block containing items associated with a particular locale that matches a user location source preference. The user can specify a static location source preference, or a follow-me, or roaming preference, in which the user's current location is used. The perishable content is selected for inclusion in an add-in block by matching a user's location preference to a locale associated with the perishable content.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: A method includes generating a dynamic audio file configured to be added to a conventional media library as a static asset, but including dynamic primary content. Generating the file includes inserting audio content formatted for processing and playout by conventional media players. The audio content includes an audible preamble at a beginning of the audio content, and primary content. Generating the file also includes inserting a tag associated with the dynamic portion of the primary content and a content start indicator. The tag specifies a source address used by an updater application to retrieve updated primary audio content. The content start indicator specifies a starting point of the primary content within the dynamic audio file, and is used by the updater application to strip the audible preamble from the dynamic audio file during the update process.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A media automation system generates multiple instances of a media broadcast stream, which includes core content common to each of the instances of the media broadcast stream, and multiple spot blocks interspersed within the media broadcast stream. Each stream instance is associated with a particular media playout device. A user notification is received and a packaged user notification is generated for inclusion in a particular instance of the media broadcast stream. Packaging the user notification includes obtaining first account information associated with a media delivery platform account of a user associated with a particular media playout device, and second account information associated with a consumer notification service account of the user. The user notification is mapped to the particular media playout device based on the first and second account information, and the packaged user notification is inserted into a first available spot block of the particular instance of the media broadcast stream.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A method includes a media services system maintaining user preference data, including historical listening patterns associated with situational parameters user preference data from a first wireless receiver in memory. The method continues with the media service system receiving current situational parameters from a second wireless receiver and comparing the situation parameters to the historical listening patterns with situation parameters from the first wireless receiver. The method continues by selecting media selection data for the second wireless receiver and then transmitting the media selection data to the second wireless receiver.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: A live media broadcast includes core content streamed to multiple users. While all consumers can be presented with the same core content, each individual consumer can be provided with individually customized content from various notification services during commercial breaks. For example, while one consumer can be provided with customized banking updates from her bank account during part of a commercial break, during that same commercial break another user might be provided with social media notifications or reminders from his calendar. Notifications or updates can be received in a text format and converted to an audio or other suitable format at an ad server, and delivered to a media automation system for insertion into a media stream in a way that integrates notifications into the listening or viewing experience without interrupting presentation of the core content.