Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize original content from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A history of user listening patterns associating geographic locations with media stations is stored and used to aid in selecting a media station. If a media station associated with a current geographical location is available, that station can be automatically tuned by a wireless media receiver. If a media station associated with the current location is not available, an alternate media station that is available at the current geographical location can be selected, and the receiver tuned to the alternate station. The alternate station can be an over-the-air (OTA) station or an Internet Protocol (IP) station. A user can be allowed to select between alternate stations having comparable content, or the user can designate a default alternate station. User listening patterns can be used to determine whether a media station is associated a particular geographic location.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: Media consumers can elect to have local news, weather, traffic, or other perishable content inserted into customized media streams. The perishable content is inserted into the media stream as an add-in block containing items associated with a particular locale that matches a user location source preference. The user can specify a static location source preference, or a follow-me, or roaming preference, in which the user's current location is used. The perishable content is selected for inclusion in an add-in block by matching a user's location preference to a locale associated with the perishable content.

Abstract: Media consumers can elect to have local news, weather, traffic, or other perishable content inserted into customized media streams. The perishable content is inserted into the media stream as an add-in block containing items associated with a particular locale that matches a user location source preference. The user can specify a static location source preference, or a follow-me, or roaming preference, in which the user's current location is used. The perishable content is selected for inclusion in an add-in block by matching a user's location preference to a locale associated with the perishable content.

Abstract: Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.

Abstract: A media receiver identifies attributes of a media station to which the media receiver is currently tuned. The media receiver monitors the signal quality of the media station. If the signal quality of the media station drops below a quality threshold, the receiver chooses an alternate station having similar content, and then tunes to the alternate station until the signal quality of the original station improves. When the signal quality of the original station rises above a re-tune threshold, the receiver can switch back to the original station. The receiver can monitor and record user listening patterns, station-switching patterns, and situational parameters, to identify times or locations at which station switches occur. This information can be used to select appropriate alternative stations, to perform pre-emptive station switches, and to determine when a station's content will be buffered with the expectation that a station's signal will drop below the quality threshold.

Abstract: The present invention provides dosing regimens for administering pharmacological chaperones to a subject in need thereof. The dosing regimens can be used to treat disorders caused by improper protein misfolding, such as lysosomal storage disorders.

Abstract: A user can specify particular news weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A method of allowing listeners to participate in broadcast programming is provided, the method generally comprising one or more of providing a library of media elements accessible by a plurality of listeners; receiving from each of at least two of the listeners a playlist of media elements, wherein at least one of the media elements in each playlist is from the library of media elements; editing the playlists using broadcast scheduling software; providing the edited playlists to the plurality of listeners for playback, and for feedback regarding the playlists; and receiving feedback from at least one of the listeners regarding the playlists. A system and apparatus are similarly provided.

Abstract: A history of user listening patterns associating geographic locations with media stations is stored and used to aid in selecting a media station. If a media station associated with a current geographical location is available, that station can be automatically tuned by a wireless media receiver. If a media station associated with the current location is not available, an alternate media station that is available at the current geographical location can be selected, and the receiver tuned to the alternate station. The alternate station can be an over-the-air (OTA) station or an Internet Protocol (IP) station. A user can be allowed to select between alternate stations having comparable content, or the user can designate a default alternate station. User listening patterns can be used to determine whether a media station is associated a particular geographic location.

Abstract: A user can specify particular news weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: The invention provides methods for determining the interactions between phage-displayed proteins and test molecules. The phage-displayed proteins are contacted with a reference moiety in the presence and absence of a test molecule; the behavior of the phage-displayed proteins as a function of concentration of the test molecule permits calculation of the binding affinity of the phage-displayed protein for the test molecule.

Abstract: A media receiver identifies attributes of a media station to which the media receiver is currently tuned. The media receiver monitors the signal quality of the media station. If the signal quality of the media station drops below a quality threshold, the receiver chooses an alternate station having similar content, and then tunes to the alternate station until the signal quality of the original station improves. When the signal quality of the original station rises above a re-tune threshold, the receiver can switch back to the original station. The receiver can monitor and record user listening patterns, station-switching patterns, and situational parameters, to identify times or locations at which station switches occur. This information can be used to select appropriate alternative stations, to perform pre-emptive station switches, and to determine when a station's content will be buffered with the expectation that a station's signal will drop below the quality threshold.

Abstract: A media receiver identifies attributes of a media station to which the media receiver is currently tuned. The media receiver monitors the signal quality of the media station. If the signal quality of the media station drops below a quality threshold, the receiver chooses an alternate station having similar content, and then tunes to the alternate station until the signal quality of the original station improves. When the signal quality of the original station rises above a re-tune threshold, the receiver can switch back to the original station. The receiver can monitor and record user listening patterns, station-switching patterns, and situational parameters, to identify times or locations at which station switches occur. This information can be used to select appropriate alternative stations, to perform pre-emptive station switches, and to determine when a station's content will be buffered with the expectation that a station's signal will drop below the quality threshold.

Abstract: A method of allowing listeners to participate in broadcast programming is provided, the method generally comprising one or more of providing a library of media elements accessible by a plurality of listeners; receiving from each of at least two of the listeners a playlist of media elements, wherein at least one of the media elements in each playlist is from the library of media elements; editing the playlists using broadcast scheduling software; providing the edited playlists to the plurality of listeners for playback, and for feedback regarding the playlists; and receiving feedback from at least one of the listeners regarding the playlists. A system and apparatus are similarly provided.

Abstract: A media receiver identifies attributes of a media station to which the media receiver is currently tuned. The media receiver monitors the signal quality of the media station. If the signal quality of the media station drops below a quality threshold, the receiver chooses an alternate station having similar content, and then tunes to the alternate station until the signal quality of the original station improves. When the signal quality of the original station rises above a re-tune threshold, the receiver can switch back to the original station. The receiver can monitor and record user listening patterns, station-switching patterns, and situational parameters, to identify times or locations at which station switches occur. This information can be used to select appropriate alternative stations, to perform pre-emptive station switches, and to determine when a station's content will be buffered with the expectation that a station's signal will drop below the quality threshold.

Abstract: A user can specify particular news, weather, traffic, or other perishable content received on a particular Internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category. In some embodiments, a user can specify that a customized station plays local news from one city at the top of the hour, traffic from another city at 10 minutes past the hour, and music or other content at other times. The user can also customize the station to select the perishable content, or other original content, from the personal libraries of specified users. Thus, a user can customize not only the genre of content or select a particular local station, but can also modify the perishable content provided by the customized station.

Abstract: A method of allowing listeners to participate in broadcast programming is provided, the method generally comprising one or more of providing a library of media elements accessible by a plurality of listeners; receiving from each of at least two of the listeners a playlist of media elements, wherein at least one of the media elements in each playlist is from the library of media elements; editing the playlists using broadcast scheduling software; providing the edited playlists to the plurality of listeners for playback, and for feedback regarding the playlists; and receiving feedback from at least one of the listeners regarding the playlists. A system and apparatus are similarly provided.