Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by force mitigation assemblies disposed in the shoe sole. A force mitigation assembly adapted for an athletic shoe includes a linkage to a wearer interface responsive to movement based on activity of the wearer. An attachment to a sole surface receives ground forces transmitted from frictional contact between the sole surface and a surface against which the sole is disposed, such as for running, turning, etc. A force mitigation assembly absorbs these forces received from the sole surface for directing the received force in a controlled manner. An elastic field in the force mitigation assembly is defined by a resilient material adapted to deform in response to the received force.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by force mitigation structures disposed in the shoe sole. A footwear article includes a split-sole system that redefines a shoe sole as coplanar surfaces having a force mitigating interface for receiving sudden forces and effectively mitigating these forces by storing kinetic energy and releasing it over time. An elastic field in the force mitigation structure is defined by a resilient material adapted to deform in response to the received force. Frictional engagement between the upper and lower sole may also be augmented by surface characteristics such as dimples, voids and lubricants, in addition to interference engagement with an elastic field.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: In one example, a network entity obtains a network packet including data. The network entity performs a deterministic mathematical computation on the data to produce a string of characters derived from the data and inserts an indication of the string of characters into the network packet. The network entity provides the indication of the string of characters to a distributed ledger based on a secret unique identifier of the network entity. The distributed ledger stores the indication of the string of characters and records an indication of a time at which the indication of the string of characters was stored in the distributed ledger. The network entity obtains, from the distributed ledger, the indication of the time and inserts the indication of the time into the network packet. The network entity provides the network packet towards a destination.

Abstract: A force dissipating device in a footwear appliance includes an actuator responsive to a displacement force from a shoe sole surface, and an elastic field of resilient, compressible material. The elastic field is elongated in a direction aligned with the displacement force, and an inclined surface is attached to the actuator and disposed against the elastic field. The actuator is adapted for movement parallel to the elastic field, while the inclined surface is oriented to compress the elastic field in a direction defined by the inclined surface. The inclined surface is oriented at an angle to compress the elastic field in a direction substantially perpendicular to vertical actuator displacement, thus providing a constant region of opposed, compressive force that is generally constant, rather than increasing with displacement distance.

Abstract: A server compiles a software program with a randomly generated string to produce compiled code. The server also computes a hash of the compiled code to produce a unique identifier for the software program. Upon receiving a request from a user to download the software program, the server generates a transaction for a blockchain that has a transaction identifier and the transaction including a user identifier for the user and the unique identifier. The server embeds the transaction identifier and the unique identifier with the software program, and downloads the software program to a computing device associated with the user.

Abstract: Systems and methods for distributed ledger-based software supply chain management are disclosed. According to one embodiment, in an information processing apparatus comprising at least one computer processor, a method for distributed ledger-based software supply chain management may include: (1) receiving, from a software tool, a metadata artifact for a software development lifecycle event; (2) writing the metadata artifact to a metadata store; and (3) updating a present state database with values for metadata keys referencing the metadata artifact in the metadata store.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed.

Abstract: A safety switching for elevator systems includes a safety function and a safety switch dedicated to the safety function. The safety switch opens or closes a safety circuit between one connection point and a second connection point as a function of a safety state of the safety function. A test function tests whether or not the safety switch opens and closes the safety circuit as a function of the safety state of the safety function. A detection device is provided for the test function. An auxiliary energy function is provided wherein an auxiliary voltage can be temporarily applied via at least the safety switch and an input part of the detection device for performing the test function. Locally between the connection points the auxiliary energy function introduces an auxiliary energy for generating the auxiliary voltage. The safety switching can be used for converting or retrofitting an existing elevator system.

Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: A safety circuit for an elevator system includes a plurality of switch contacts, at least one first switch contact, and a control unit. The at least one first switch contact can be switched electronically and can be bridged using a conductive bridging element, in particular for maintenance or testing purposes. Additionally, the control unit is directly or indirectly connected to the safety circuit. The at least one first switch contact can be switched on the basis of instructions of the control unit in order to change the state of the safety circuit. In the process, the at least one control unit detects the absence of the state change of the safety circuit, in particular when the at least one first switch contact is being bridged by the bridging element.

Abstract: A sealing band arrangement for a gas turbine including first and second adjoining rotor disks each including a disk arm having a slot. The sealing band arrangement includes at least one first seal strip segment located within the slots, wherein the seal strip segment includes first and second ends. The sealing band arrangement also includes a tab section that extends from the first end in order to form an underlap seal with an adjacent second seal strip segment. The underlap seal enables a thickness of the first and second ends to be substantially equivalent to a thickness of the first seal strip segment in order to improve wear life of the seal strip segment. The sealing band arrangement further includes at least one wide portion formed in the first seal strip segment wherein the wide portion is wider than a remaining portion of the first seal strip segment.

Abstract: A server compiles a software program with a randomly generated string to produce compiled code. The server also computes a hash of the compiled code to produce a unique identifier for the software program. Upon receiving a request from a user to download the software program, the server generates a transaction for a blockchain that has a transaction identifier and the transaction including a user identifier for the user and the unique identifier. The server embeds the transaction identifier and the unique identifier with the software program, and downloads the software program to a computing device associated with the user.

Abstract: A system for decentralized tracking of assets (devices (hardware) or software) is provided. One or more servers are configured to execute blockchain software for a blockchain that tracks ownership and usage of devices or software. Each transaction in the blockchain includes an asset identifier that identifies a particular device or instance of software and an owner identifier that identifies a particular owner of a particular device or instance of software. One or more computing devices are configured to run a blockchain client application that communicates with the blockchain software to provide updates to the blockchain as to ownership and usage of devices or software. The blockchain client application configured to add a new transaction to the blockchain to specify a new owner identifier when upon a sale/transfer and to specify when an update or change is made to a particular device or instance of software.

Abstract: A system and method for improved location tracking of a target device based on location estimates for multiple types of location technologies/sensor types. A received signal strength location estimate of a target device based on wireless transmissions made by the target device received at a plurality of receiver devices at known locations in a location region. A first search area for the target device is derived based on the received signal strength location estimate. An ultrasound based area in which the target device is estimated to be is derived based on reception by the target device of a particular ultrasound beacon in the location region. An intersection of the first search area and the ultrasound based area is computed to produce a second search area. A location estimate of the target device in the second search area is computed based at least on the received signal strength location estimate.

Abstract: In an elevator installation, an elevator car is movably arranged alongside guide rails and the elevator car is equipped with a brake system with preferably two safety brakes. A movement monitoring system monitors the movement parameters of the elevator car and triggers corresponding warnings or safety measures, if permissible threshold values are exceeded or it provides determined adjusted movement parameters to an elevator control. The movement monitoring system determines a first movement parameter in a time interval and detects an acceleration of the elevator car. The movement monitoring system determines the time interval for determining the adjusted movement parameter as a function of the detected acceleration.

Abstract: An impact absorbing footwear device employs opposed planar sole portions engaged by a selective resistance coupling that biases the opposed planar sole portions in a non-linear manner in response to forces exerted by the wearer against the sole portion in frictional contact with a floor surface. The planar sole portions are disposed in a footwear appliance that takes the form of an athletic shoe sole. The selective resistance coupling includes a plurality of resilient deformation members that engage the planar sole portions in an opposed circumferentially aligned manner, selectively deform in response to pressure exerted by the wearer for preventing ACL and other impact related injuries, and recover to an undeformed rest position without breakaway to allow the wearer uninterrupted usage while dampening forces that surpass an injury threshold from the resilient deformation that allows the planar sole portions to temporarily misalign.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed.