Abstract: A laser ablation system, and method, facilitates the execution of user-defined scans (i.e., in which a laser beam is scanned across a sample along a beam trajectory to ablate or dissociate a portion of the sample) and enables the user define additional scans while a scan is being executed.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

Abstract: Systems and methods for multivariate Artificial Intelligence (AI) smart cards are provided. An AI smart card may include, for example, pre-stored policy data that may be utilized as a portion of multivariate input by a suite of AI modules to formulate and analyze a claim of loss.

Abstract: The present disclosure provides an aircraft security door as well as methods, systems and apparatus for handling an aircraft security door. In one implementation, a method for installing an aircraft security door onto an aircraft is disclosed. The method includes transferring the aircraft security door to an aircraft service stair, supporting the aircraft security door by a bridge crane coupled to the aircraft service stair, positioning the aircraft service stair in proximity to a fuselage of the aircraft adjacent to an opening in the fuselage, positioning the aircraft security door relative to the opening using the bridge crane, and securing the aircraft security door to the opening.

Abstract: The present disclosure is directed to various ways of improving the functioning of computer systems, information networks, data stores, search engine systems and methods, and other advantages. Among other things, provided herein are methods, systems, components, processes, modules, blocks, circuits, sub-systems, articles, and other elements (collectively referred to in some cases as the “platform” or the “system”) that collectively enable, in a single database and system, the development and maintenance of a set of universal contact objects that relate to the contacts of a business and that have attributes that enable use for a wide range of activities, including sales activities, marketing activities, service activities, content development activities, and others, as well as improved methods and systems for sales, marketing and services that make use of such universal contact objects.

Abstract: The present disclosure is directed to self-synchronizing devices that can connect and self-synchronizes voltage, frequency and phase of two or more power sources. The disclosed embodiments enable a modular power system to serve as the primary or secondary source of power for applications requiring loads from a few kilowatts (kW) to the scale of megawatts (MW). The modular system is generalized to use either a single or multiple power generation sources at once, with the ability to connect and self-synchronize voltage, frequency, and phase of a variety of different types of power sources. Power control systems designed to function with self-synchronizing technology enable a modular power system to satisfy a wide variety of needs, simplifying the existing method of achieving synchronization and enabling new features of resiliency and expandability. The self-synchronization can be implemented into a wide variety of electronics including but not limited to inverters and generator controllers.

Abstract: Disclosed herein are system, method, and computer program product embodiments for performing in-flight transformations of data streams. Complex event processing (CEP) operating on event records from various data streams can operate by storing the streamed event record data in a database, and then querying the data to perform a data transformation. However, in order to improve the performance of the data transformations and streamline CEP, a serverless architecture is introduced that can perform data transformations directly on streams, using attributes of the streamed record data defined in a schema. The resulting transformed data can then be provided by the serverless architecture to the CEP for direct access of the data most needed by the CEP.

Abstract: The present disclosure is directed to various ways of improving the functioning of computer systems, information networks, data stores, search engine systems and methods, and other advantages. Among other things, provided herein are methods, systems, components, processes, modules, blocks, circuits, sub-systems, articles, and other elements (collectively referred to in some cases as the “platform” or the “system”) that collectively enable, in a single database and system, the development and maintenance of a set of universal contact objects that relate to the contacts of a business and that have attributes that enable use for a wide range of activities, including sales activities, marketing activities, service activities, content development activities, and others, as well as improved methods and systems for sales, marketing and services that make use of such universal contact objects.

Abstract: The present disclosure is directed to self-synchronizing devices that can connect and self-synchronizes voltage, frequency and phase of two or more power sources. The disclosed embodiments enable a modular power system to serve as the primary or secondary source of power for applications requiring loads from a few kilowatts (KW) to the scale of megawatts (MW). The modular system is generalized to use either a single or multiple power generation sources at once, with the ability to connect and self-synchronize voltage, frequency, and phase of a variety of different types of power sources. Power control systems designed to function with self-synchronizing technology enable a modular power system to satisfy a wide variety of needs, simplifying the existing method of achieving synchronization and enabling new features of resiliency and expandability. The self-synchronization can be implemented into a wide variety of electronics including but not limited to inverters and generator controllers.

Abstract: The invention provides methyl-substituted pyridine and pyridazine compounds, derivatives thereof, and methods of their use. The compounds are useful as pharmacological agents to treat a variety of conditions, including various pain states, itch, and cough.

Abstract: A method includes: receiving system data corresponding to an engine system. The system data includes a plurality of remaining useful life (RUL) values with each RUL value associated with a component of the engine system. The method further includes: comparing a first RUL value to a service interval threshold; generating a near-term service recommendation including a first list of components that correspond to each RUL value that are less than or equal to the service interval threshold; generating an extended term service recommendation including a second list of components and a downtime prediction; generating a coordinated service recommendation by dynamically populating one or more fields of the coordinated service recommendation based on the near-term service recommendation and the extended term service recommendation; and providing the combined service recommendation to a user device.

Abstract: In certain embodiments, machine learning and lineage data may be used to manage data. In some embodiments, a computing system may use lineage data to identify two datasets that may be related. The computing system may determine that a user has access to a derivative dataset but does not have access to an original dataset that was used to create the derivative dataset. In response, the computing system may use a machine learning model to generate a similarity score indicating a level of similarity between the original dataset and the derivative dataset. If the similarity score satisfies a threshold score, the computing system may modify access rights of the user so that the user is unable to access a portion of the data in the derivative dataset.

Abstract: Systems and methods for determining a remaining useful life (RUL) of a component of an engine system are provided. A method includes: receiving component data comprising sensor data corresponding to a component and engine data; pre-processing the component data by removing a first set of sensor data values that correspond to a first set of engine data values of the engine data; aggregating the pre-processed component data by grouping a second set of sensor values of the sensor data; determining a RUL for the component based on a RUL model that correlates at least a portion of the aggregated data to RUL values; adjusting the RUL based on at least one of detecting a service event or determining that one or more sensor data values of the sensor data are outside a predetermined range of values; and providing the RUL to a user device.

Abstract: A laser ablation system, and method, facilitates the execution of user-defined scans (i.e., in which a laser beam is scanned across a sample along a beam trajectory to ablate or dissociate a portion of the sample) and enables the user define additional scans while a scan is being executed.

Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.

Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist, an oligosaccharide stabilizing agent and an optional absorption enhancer. The kappa opioid receptor agonist may be coated with, embedded in or mixed with an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists, the oligosaccharide and the absorption enhancer of the invention. The invention further provides methods of manufacture of the formulations and methods of their use for the prophylaxis, inhibition and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation. The methods of use include administering to the mammal the formulation of the kappa opioid receptor agonist, oligosaccharide and optional absorption enhancers.

Abstract: In certain embodiments, machine learning and lineage data may be used to manage data. In some embodiments, a computing system may use lineage data to identify two datasets that may be related. The computing system may determine that a user has access to a derivative dataset but does not have access to an original dataset that was used to create the derivative dataset. In response, the computing system may use a machine learning model to generate a similarity score indicating a level of similarity between the original dataset and the derivative dataset. If the similarity score satisfies a threshold score, the computing system may modify access rights of the user so that the user is unable to access a portion of the data in the derivative dataset.

Abstract: A hermetically sealed electronics module includes a core IC installed on a substrate. A collar surrounds the core IC and is sealed to the substrate and to a lid, forming a sealed chamber. A heat spreader bonded to an internal surface of the lid extends downward into proximal thermal contact with the core IC. A thin layer of TIM can be applied between the heat spreader and core IC. The heat spreader does not overlap any tall components that extend above the core IC, and can extend over regions adjacent to the core IC. Tall components can be limited to a periphery of the chamber, and/or the heat spreader can include openings that surround central tall components. The heat spreader can be soldered or welded to the lid over an entire upper surface of the heat spreader. X-ray and/or CSAM scanning can detect heat spreader bonding flaws.

Abstract: A blade assembly includes a support frame, a cutting blade, a motor to drive the cutting blade, a support shaft operatively coupled to the support frame to permit pivotal movement of the support frame, and an actuator operatively coupled to the support frame to reciprocally move the slicing assembly between an extended position and a retracted position. When the slicing assembly is in the extended position, a plane of the cutting blade is substantially co-planar with a cutting plane of the food product, and the cutting blade slices the food product. Conversely, when the slicing assembly is in the retracted position, the plane of the cutting blade is disposed at a predetermined angle away from the cutting plane of the food product, and the cutting blade does not contact the food product.

Abstract: Systems, methods, and computer readable media for monitoring distributed computing events are disclosed. The method includes defining parameters for a plurality of monitored assets, receiving status data for each monitored asset during the event, determining if each monitored asset's status is within the defined parameters during the event, providing an indication to a user if a monitored asset's status is outside the defined parameters, receiving instructions from the user for each monitored asset outside of the defined parameters, transmitting the instructions to the monitored asset outside of the defined parameters, executing the instructions on the monitored asset outside of the defined parameters, and providing an assessment of the event after the event concludes.