Abstract: The invention provides formulations for oral delivery of a therapeutic wherein the formulation comprises a kappa opioid receptor agonist, an oligosaccharide stabilizing agent and an optional absorption enhancer. The kappa opioid receptor agonist may be coated with, embedded in or mixed with an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists, the oligosaccharide and the absorption enhancer of the invention. The invention further provides methods of manufacture of the formulations and methods of their use for the prophylaxis, inhibition and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation. The methods of use include administering to the mammal the formulation of the kappa opioid receptor agonist, oligosaccharide and optional absorption enhancers.

Abstract: The present disclosure is directed to various ways of improving the functioning of computer systems, information networks, data stores, search engine systems and methods, and other advantages. Among other things, provided herein are methods, systems, components, processes, modules, blocks, circuits, sub-systems, articles, and other elements (collectively referred to in some cases as the “platform” or the “system”) that collectively enable, in a single database and system, the development and maintenance of a set of universal contact objects that relate to the contacts of a business and that have attributes that enable use for a wide range of activities, including sales activities, marketing activities, service activities, content development activities, and others, as well as improved methods and systems for sales, marketing and services that make use of such universal contact objects.

Abstract: Spark plugs are disclosed that include electrode arrangements to improve the charge flow into and out of the annular volume around the insulator nose and a pre-chamber volume of a pre-chamber device, thus directing a purge of exhaust gases trapped in the annular volume to a space formed by the exterior of the spark plug body and the interior of the pre-chamber device.

Abstract: Humidification systems and methods to introduce water vapor to a laser-ablated sample prior to introduction to an ICP torch are described. A system embodiment includes, but is not limited to, a water vapor generator configured to control production of a water vapor stream and to transfer the water vapor stream to at least one of a sample chamber of a laser ablation device or a mixing chamber in fluid communication with the laser ablation device, wherein the mixing chamber is configured to receive a laser-ablated sample from the laser ablation device and direct the laser-ablated sample to an inductively coupled plasma torch.

Abstract: Systems, methods, and computer readable media for monitoring distributed computing events are disclosed. The method includes defining parameters for a plurality of monitored assets, receiving status data for each monitored asset during the event, determining if each monitored asset's status is within the defined parameters during the event, providing an indication to a user if a monitored asset's status is outside the defined parameters, receiving instructions from the user for each monitored asset outside of the defined parameters, transmitting the instructions to the monitored asset outside of the defined parameters, executing the instructions on the monitored asset outside of the defined parameters, and providing an assessment of the event after the event concludes.

Abstract: The present disclosure is directed to various ways of improving the functioning of computer systems, information networks, data stores, search engine systems and methods, and other advantages. Among other things, provided herein are methods, systems, components, processes, modules, blocks, circuits, sub-systems, articles, and other elements (collectively referred to in some cases as the “platform” or the “system”) that collectively enable, in a single database and system, the development and maintenance of a set of universal contact objects that relate to the contacts of a business and that have attributes that enable use for a wide range of activities, including sales activities, marketing activities, service activities, content development activities, and others, as well as improved methods and systems for sales, marketing and services that make use of such universal contact objects.

Abstract: In certain embodiments, machine learning and lineage data may be used to manage data. In some embodiments, a computing system may use lineage data to identify two datasets that may be related. The computing system may determine that a user has access to a derivative dataset but does not have access to an original dataset that was used to create the derivative dataset. In response, the computing system may use a machine learning model to generate a similarity score indicating a level of similarity between the original dataset and the derivative dataset. If the similarity score satisfies a threshold score, the computing system may modify access rights of the user so that the user is unable to access a portion of the data in the derivative dataset.

Abstract: In certain embodiments, machine learning and lineage data may be used to manage data. In some embodiments, a computing system may use lineage data to identify two datasets that may be related. The computing system may determine that a user has access to a derivative dataset but does not have access to an original dataset that was used to create the derivative dataset. In response, the computing system may use a machine learning model to generate a similarity score indicating a level of similarity between the original dataset and the derivative dataset. If the similarity score satisfies a threshold score, the computing system may modify access rights of the user so that the user is unable to access a portion of the data in the derivative dataset.

Abstract: A system for facilitating automated handling using laser ablation system is described that includes a sample generation system. In an embodiment, the sample generation system can include a sample chamber with a sample chamber body, a transmission window and a sealing member coupled to the sample chamber body, an inlet conduit extending through the sample chamber body and intersecting a sidewall of the interior space, and an outlet conduit extending through the sample chamber body and intersecting at least one of the sidewall of the interior or a lower surface of the sample chamber body; a placement system including a frame, and an actuator assembly coupled to the frame, where the actuator assembly is configured to place the sample adjacent to the sample chamber for laser ablation; and a laser configured to produce a laser beam that is propagated along a beam path to irradiate the sample.

Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.

Abstract: An example aspiration system includes an inner member configured to be received within an aspiration catheter lumen and disrupt a thrombus positioned within vasculature of a patient. The inner member includes a distal member at a distal portion of an elongated support member, where the distal member is configured to fit within the aspiration catheter lumen. The distal member defines a larger cross-sectional dimension than the elongated support member, the cross-section being taken in a direction orthogonal to a longitudinal axis of the support member, and is configured to be deployed distally outward from a distal opening of the aspiration catheter lumen to contact and disrupt a thrombus to facilitate the efficiency of a medical aspiration procedure. The distal member may include one or more tapered portions and a surface disruption configured to aid with the thrombus disruption.

Abstract: Systems and methods for multivariate Artificial Intelligence (AI) smart cards are provided. An AI smart card may include, for example, pre-stored policy data that may be utilized as a portion of multivariate input by a suite of AI modules to formulate and analyze a claim of loss.

Abstract: Systems, apparatus, interfaces, methods, and articles of manufacture that provide for Artificial Intelligence (AI) User Interface (UI) and/or Graphical User Interface (GUI) generation.

Abstract: Disclosed are multi-ply tissue products, particularly creped and through-air dried tissue products, having cloth like properties, such as good drapability and durability. For example, the products generally comprise two plies and have a geometric mean slope (GM Slope) less than about 10.0 kg and a geometric mean tensile energy absorption (GM TEA) of about 15 g·cm/cm2 or greater. In certain instances, the tissue products also have a low degree of stiffness, such as a Stiffness Index less than about 5.00. The tissue products may be prepared from webs manufactured by a print-crepe process that deposits a latex polymer on at least one of the outer surfaces of the tissue web.

Abstract: Systems, apparatuses, and methods of controlling an ignitor are disclosed. A method includes: receiving, by a controller, fuel quality data regarding a fuel for a spark-ignition engine; determining, by the controller, a fuel quality metric based on the fuel quality data; and controlling, by the controller, an ignition energy characteristic of an ignitor in response to the fuel quality metric.

Abstract: A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell.

Abstract: Systems and methods for multivariate Artificial Intelligence (AI) smart cards are provided. An AI smart card may include, for example, pre-stored policy data that may be utilized as a portion of multivariate input by a suite of AI modules to formulate and analyze a claim of loss.

Abstract: A multi-fitting rotatable fluid connection apparatus comprising a fluid entry fitting and first and second fluid discharge fittings. The fluid entry fitting comprises a first end connector threaded for attachment to a fluid source, and first and second distribution connectors. The first fluid discharge fitting has a first intake connector which receives fluid from the first distribution connector. A first rotation member is coupled between the first intake connector and the first distribution connector such that the first fluid discharge fitting is rotatable about a first axis of rotation. The second fluid discharge fitting has a second intake connector which receives fluid from the second distribution connector. A second rotation member is coupled between the second intake connector and the second distribution connector such that the second fluid discharge fitting is rotatable about a second axis of rotation.

Abstract: Systems, apparatus, interfaces, methods, and articles of manufacture that provide for Artificial Intelligence (AI) User Interface (UI) and/or Graphical User Interface (GUI) generation.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.