Patents by Inventor J. Simons

J. Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hypoxic NK cells and methods therefor
    Patent number: 11221328
    Abstract: Detection of under-expression of selected genes in NK cells is used to confirm a hypoxic tumor microenvironment that is ordinarily suppressive with respect to ADCC and cytotoxic cell killing of NK cells. Most notably, while hypoxia is known to upregulate HIF-1? and genes under the control of HIF-1?, hypoxia in a tumor microenvironment led to under-expression of selected genes, including HIF-1?. Thus, gene expression analysis of certain genes on NK cells can be used to detect conditions in a tumor that would indicate use of haNK cells.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: January 11, 2022
    Assignee: NantCell, Inc.
    Inventors: Patrick Soon-Shiong, Shahrooz Rabizadeh, Kayvan Niazi, Stephen Charles Benz, Laurent H. Boissel, Hans Klingemann, Barry J. Simon
  • VAGAL NERVE STIMULATION FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS
    Publication number: 20220001166
    Abstract: Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 6, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Tumoricidal and antimicrobial compositions and methods
    Patent number: 11213547
    Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: January 4, 2022
    Assignee: ImmunityBio, Inc.
    Inventors: Hans G. Klingemann, Barry J. Simon
  • DEVICES AND METHODS FOR NERVE STIMULATION
    Publication number: 20210402173
    Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a spinal nerve within the patient. The electrical signal is generated within the housing and comprises bursts of pulses. Each burst of pulses comprises a burst period and a constant period, Each burst period comprises 2 to 20 pulses and at least a portion of each constant period comprises zero pulses. At least one of the pulses has a duration of about 50 microseconds to about 1000 microseconds.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Coordinated multi-prong cancer therapy
    Patent number: 11207392
    Abstract: Cancer is treated using coordinated treatment regimens that uses various compounds and compositions that drive a tumor from the escape phase of cancer immunoediting to the elimination and equilibrium phase of cancer immunoediting.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 28, 2021
    Assignees: NantCell Inc., Nant Holdings IP LLC
    Inventors: Patrick Soon-Shiong, Kayvan Niazi, Shahrooz Rabizadeh, Hans G. Klingemann, Laurent H. Boissel, Barry J. Simon
  • Genetically modified NK-92 cells and monoclonal antibodies for the treatment of cancer
    Patent number: 11207350
    Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: December 28, 2021
    Assignee: ImmunityBio, Inc.
    Inventors: Tien Lee, Hans G. Klingemann, Barry J. Simon, Laurent Boissel
  • Neurotherapeutic video game for improving spatiotemporal cognition
    Patent number: 11207010
    Abstract: The disclosed embodiments relate to a system that uses a video game to improve spatial and/or temporal information-processing capabilities of a user. During operation, the system enables the user to play the video game. During execution of the video game, the system first measures spatial and/or temporal information-processing capabilities of the user during the course of playing the video game. Next, the system uses the measured spatial and/or temporal information-processing capabilities to control a spatial placement and/or a temporal presentation rate of target items that the user is required to respond to during subsequent game play to stimulate enhancement of the user's spatial and/or temporal information-processing capabilities.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: December 28, 2021
    Assignee: The Regents of the University of California
    Inventor: Anthony J. Simon
  • VAGAL NERVE STIMULATION FOR TREATING POST-TRAUMATIC STRESS DISORDER
    Publication number: 20210386992
    Abstract: Devices, systems and methods are disclosed for treating one or more symptoms of post-traumatic stress disorder (PTSD) in a patient. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of PTSD are reduced. For chronic treatment of PTSD, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.
    Type: Application
    Filed: August 30, 2021
    Publication date: December 16, 2021
    Inventors: Bruce J. Simon, Joseph P. Errico
  • VAGAL NERVE STIMULATION DEVICES AND METHODS FOR TREATING MEDICAL CONDITIONS
    Publication number: 20210392447
    Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
    Type: Application
    Filed: August 30, 2021
    Publication date: December 16, 2021
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Medical self-treatment using non-invasive vagus nerve stimulation
    Patent number: 11197998
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: December 14, 2021
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Systems and methods for vagal nerve stimulation
    Patent number: 11191953
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses administered 2 to 5 times per day. The treatment paradigm may further comprise one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and/or serotonin.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: December 7, 2021
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • OUTDOOR COOKING STATION FOR SMOKING FOOD AND METHOD THEREOF
    Publication number: 20210369052
    Abstract: Embodiments of an outdoor cooking station having a main body with a pellet feeding system integrated with the cooking station for feeding heated smoke to a cooking chamber. The pellet feeding system utilizes a paddle wheel for feeding pellets to be burned and generating heated smoke. The heated smoke moves through a ducting system that is adjustable for distributing smoke to the cooking chamber.
    Type: Application
    Filed: June 2, 2021
    Publication date: December 2, 2021
    Inventors: Tyler J. Fullmer, Christopher L. Hanks, David Clark, Michael R. Giebel, Paul J. Simon
  • SYSTEM AND METHOD FOR RECEIVING REAL-TIME CONSUMER TRANSACTIONAL FEEDBACK
    Publication number: 20210374786
    Abstract: Systems, methods, and storage media for operating a wireless device are disclosed. Exemplary implementations may: receive information pertaining to a trigger event, wherein the trigger event relates to a transaction associated with a consumer and the transaction comprises an identifier associated with the consumer; based on the trigger event: generate a survey comprising one or more requests for information related to the transaction, select an incentive offer from an incentive offer database, transmit, for display on a wireless device of the consumer, a notification to the wireless device, wherein the notification comprises the survey and information pertaining to the incentive offer; receive one or more responses to the survey; and responsive to receiving the one or more responses, store the incentive offer in a digital wallet associated with the identifier.
    Type: Application
    Filed: August 16, 2021
    Publication date: December 2, 2021
    Applicant: MBP Insights, Inc.
    Inventor: James J. Simon
  • Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
    Patent number: 11179560
    Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: November 23, 2021
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Non-Invasive Treatment of Parkinson's Disease
    Publication number: 20210353943
    Abstract: Methods and devices are disclosed for the non-invasive treatment of Parkinson's disease through the delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of the vagus nerve to treat one or more symptoms of Parkinson's disease. This modulation may inhibit neuroinflammation and/or increase levels of at least one neurotrophic factor to promote the survival of dopamine producing cells in patients suffering from the conditions of Parkinson's disease.
    Type: Application
    Filed: July 30, 2021
    Publication date: November 18, 2021
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Nant Cancer Vaccine
    Publication number: 20210353730
    Abstract: Cancer is treated using coordinated treatment regimens that uses various compounds and compositions that drive a tumor from the escape phase of cancer immunoediting to the elimination and equilibrium phase of cancer immunoediting.
    Type: Application
    Filed: August 2, 2021
    Publication date: November 18, 2021
    Inventors: Patrick Soon-Shiong, Kayvan NIAZI, Shahrooz RABIZADEH, Hans G. Klingemann, Laurent H. Boissel, Barry J. Simon
  • Centralized data access tool implementing resource governance
    Patent number: 11169997
    Abstract: Methods, systems, apparatus, and non-transitory media are described for governing resources used to execute and retrieve database entries in accordance with an ad-hoc structured query language (SQL) script. Various aspects are described to determine whether a written SQL script is optimized, to execute the SQL script if it is optimized, and to otherwise reject unoptimized SQL scripts. The resources used during the execution of the SQL script may further be monitored to control resource use, and the execution of SQL scripts may be ceased if a processor-based resource limit threshold is exceeded. The SQL script execution system may be implemented in a wide variety of systems, such as database servers. The scripts may be executed in conjunction with scrubbing and encryption scripts to protect sensitive data, and thus the SQL scripts may be received via one or more public APIs.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: November 9, 2021
    Assignee: STATE FARM MUTUAL AUTOMOBILE INSURANCE COMPANY
    Inventors: Gregory James Debo, Richard J. Simon, Larry Koenen, Adam Jelinek, Vaidya Balasubramanian Pillai, Richard Berglund, Jerry Burger
  • Multi-Portion Radio Transmissions
    Publication number: 20210336830
    Abstract: Techniques are disclosed relating to generating and receiving radio frames with multiple portions that have different target geographic areas. A data frame may include a first partition that includes a physical layer encoding of first data to be transmitted in a first geographic area, where the first geographic area is defined by a first threshold distance from the one or more transmitters. The data frame may include a second that includes a physical layer encoding of second data to be transmitted in a second geographic area, where the second geographic area is defined by a second, greater threshold distance from the one or more transmitters.
    Type: Application
    Filed: July 6, 2021
    Publication date: October 28, 2021
    Inventors: Michael J. Simon, Kevin A. Shelby, Mark Earnshaw
  • DEVICES AND METHODS FOR DETERMINING THE EFFECTIVENESS OF ELECTRICAL STIMULATION
    Publication number: 20210330972
    Abstract: Methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by electrical stimulation of a nerve. The method comprises applying a first stimulus to a patient having a medical condition and measuring a first baseline physiological response from the patient. An electrical impulse is applied to a nerve within the patient and second stimulus is applied to the patient. A second physiological response evoked by the second stimulus is measured and compared to the first baseline physiological response. The methods may be used to optimize the placement of a stimulator, to test whether a patient is a suitable candidate for treatment using nerve stimulation, and/or to select the stimulation parameters that optimize acute or chronic treatment.
    Type: Application
    Filed: May 12, 2021
    Publication date: October 28, 2021
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Band segmented bootstraps and partitioned frames
    Patent number: 11153056
    Abstract: An apparatus and a method are provided for generating and transmitting one or more band segmented bootstrap signals. For example, a transmitter may be configured to generate a plurality of sequence numbers and apply cyclic shift to each of the plurality of sequence number. The transmitter is further configured to map each of the shifted sequence numbers to at least one frequency domain subcarrier of a plurality of frequency domain subcarriers, and translate each subcarrier of the plurality of subcarriers to a time domain sequence. Each subcarrier of the plurality of subcarriers may be shifted with respect to other subcarriers of the plurality of subcarriers, thereby aligning each segment of the band segmented bootstrap signals next to each other in the frequency domain.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: October 19, 2021
    Assignee: SINCLAIR BROADCAST GROUP, INC.
    Inventor: Michael J. Simon