Abstract: A method for operating a transmitting device to communicate with a receiving device is described herein. The method includes the step of the transmitting device selecting a root index value from a set of root index values. The method further includes the step of the transmitting device generating a frequency domain Constant Amplitude Zero Auto-Correlation sequence based on the selected root index value. The method further includes the step of the transmitting device modulating the Constant Amplitude Zero Auto-Correlation sequence by a pseudo-noise sequence. The method further includes the step of the transmitting device generating an Orthogonal Frequency Division Multiplexing symbol, wherein the frequency domain Constant Amplitude Zero Auto-Correlation sequence modulated by the pseudo-noise sequence defines subcarrier values for the Orthogonal Frequency Division Multiplexing symbol.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface for contacting an outer skin surface of a patient and a pulse generator coupled to the contact surface. The pulse generator is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The pulse generator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: The present invention provides novel peptides, compositions, and methods for creating quantitative novel compositions, as well as methods for creating quantitative standards to calibrate analytes. These peptides, compositions, and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers (e.g., Tau). Also provided are kits comprising the peptides or compositions described herein, for use in assays (e.g., sandwich immunoassays).

Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.

Abstract: A system for assessing brain health of a user includes an electronics module including an active brainwave sensor that collects channels of electroencephalography (EEG) brainwave data, a plurality of biological sensors, and a stimulation device. The biological sensors include a microphone that captures verbal responses of the subject during a battery of tasks, an image sensor that records eye positions, eye saccade and other biometric identification information, an accelerometer, a gyrometer, a thermometer, a pulse oximetry sensor, a dermal skin conductance sensor, and key strokes, mouse clicks or touch events to measure cognitive data of the user. The stimulation device applies a battery of tasks including a visual or photic stimulant, an auditory stimulant, a gastronomic stimulant, an olfactory stimulant, a touch stimulant, and a cognitive challenge stimulant to the user. The plurality of biological sensors simultaneously measure the body's response to stimulants for recordation by the electronics module.

Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.

Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.

Abstract: Systems and methods for reducing or inhibiting an inflammatory response in a patient include a source of energy and one or more electrodes coupled to the source of energy and positionable near a vagus nerve of the patient to deliver the electrical impulse to the vagus nerve. The electrical impulse is sufficient to either inhibit a release of a pro-inflammatory cytokine, such as TNF-alpha, or increase an anti-inflammatory competence of a cytokine, such as TGF-beta, in the patient, thereby inhibiting the inflammatory response. The electrical impulse may be delivered transcutaneously and non-invasively through an outer skin surface of the patient to the vagus nerve.

Abstract: A base station may generate and transmit a transport stream including a sequence of frames. A frame may include a plurality of partitions, where each partition includes a corresponding set of OFDM symbols. For each partition, the OFDM symbols in that partition may have a corresponding cyclic prefix size and a corresponding FFT size, allowing different partitions to be targeted for different collections of user devices, e.g., user devices having different expected values of maximum delay spread and/or different ranges of mobility. The base station may also dynamically re-configure the sample rate of each frame, allowing further resolution in control of subcarrier spacing. By allowing the cyclic prefixes of different OFDM symbols to have different lengths, it is feasible to construct a frame that confirms to a set payload duration and has arbitrary values of cyclic prefix size per partition and FFT size per partition. The partitions may be multiplexed in time and/or frequency.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts with a frequency of 1 to 100 Hz. Each of the bursts has 2 to 20 pulses with a duration of about 50 microseconds to about 1000 microseconds.

Abstract: Devices and methods are provided for treating a patient that include delivering an electrical signal to a target nerve within the patient. The electrical signal has parameters selected to modulate the target nerve for therapeutic purposes to treat a disease or disorder in the patient.

Abstract: Techniques are disclosed relating to generating and receiving radio frames with multiple portions that have different encoding schemes. An apparatus may include one or more processing elements configured to receive, via a wireless radio, wireless data that includes a plurality of portions that each include multiple orthogonal frequency-division multiplexing (OFDM) symbols. Different ones of the portions have different frequency transform sizes and different sampling rates. The wireless data may also include control data that indicates the frequency transform sizes and sampling rates for the ones of the portions. The apparatus may select, based on the control data and a determined velocity of the apparatus, one or more but not all of the plurality of portions and may decode the selected one or more portions to determine data represented by the OFDM symbols in the selected one or more portions. Different portions of the wireless data may be adapted for decoding by devices moving at different maximum velocities.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient. The systems and methods of the present invention reduce the expression of inflammatory mediators that are elevated in ARDS and other inflammatory or allergic disorders, thereby ameliorating the overactivity of the immune reaction in patient's suffering from certain disorders, such as the coronavirus. This therapy may include a feedback mechanism to provide potent anti-inflammatory benefits without the negative side effects of conventional immune suppression techniques and drugs, such as steroids and other nebulized drugs.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts of about 2 to about 20 pulses and the pulses oscillate between a positive voltage and a negative voltage within each burst.

Abstract: Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods incluce positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The the electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

Abstract: An example method of mapping a plurality of modulation symbols of a plurality of physical layer pipes present in a frame to a resource grid of data cells for the frame is described. The modulation symbols of the plurality of physical layer pipes are represented by a two-dimensional array comprising the modulation symbol values for the plurality of physical layer pipes and the resource grid of data cells is represented by a one-dimensional sequentially indexed array.

Abstract: The ATSC 3.0 physical layer broadcast standard is extended with new OFDM numerology, L1 signaling and frame structure aligned with 5G. This is done to enable improved broadcast mobility and convergence 5G release 16 as a Non-3GPP access network. The 5G core network and Broadcast core network interwork over defined interfaces to enable convergence layer 3. This enables improvements of broadcast physical layer for physics of broadcast. The 5G unicast physical layer is enhanced for physics of unicast, and then both are converged at layer 3. This is novel and has many benefits compared to the legacy LTE broadcast method (e.g., Evolved Multimedia Broadcast Multicast Services (eMBMS)), which combines both broadcast and unicast into a single shared LTE frame at layer 1. The eMBMS method is then improved for dominate unicast mode in shared L1 frame. The result is the broadcast performance and efficiency in eMBMS are less than optimal.

Abstract: Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of treating lower urinary tract disorders using energy that is delivered noninvasively by the devices. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In embodiments of the disclosed methods, a posterior tibial nerve of a patient is stimulated non-invasively. Methods are disclosed for selecting protocol parameters for a nerve stimulation session for treating each individual patient, wherein modules of the bladder of the patient are represented as coupled non-linear oscillators.

Abstract: A Next Generation Broadcast Platform (NGBP) is disclosed that utilizes 5G software-defined networking (SDN) and network function virtualization (NFV) technologies. The NGBP is designed to enable a new paradigm for broadcasters, wherein the model of fixed wireless spectrum access granted only to the licensees of the spectrum is replaced by a flexible model in which licensed spectrum is pooled together and allocated dynamically to broadcast licensees as well as outside tenants. The NGBP is implemented using SDN/NFV technology, and includes a broadcast market exchange (BMX) entity that allocates the spectrum between tenants based on service level agreements (SLAs) with those users. The NGBP also includes an internet protocol (IP) core and a broadcast centralized radio access network (BC-RAN) which apply the major network functions to broadcaster content in accordance with the determinations of the BMX.