Patents by Inventor J. Simons

J. Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11304977
    Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: April 19, 2022
    Assignee: ImmunityBio. Inc.
    Inventors: Hans G. Klingemann, Barry J. Simon
  • Patent number: 11298535
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that applies an electrical impulse transcutaneously through an outer skin surface of the patient. The electrical impulse includes pulses having a frequency of about 1 kHz to about 20 kHz. The device housing may transmit data to or from a patient interface device, such as a mobile phone or computer, relating to the stimulation parameters. The interface device in turn may communicate with a database contained within other computers, via a network or the internet.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: April 12, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11297445
    Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 5, 2022
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11287423
    Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 29, 2022
    Assignee: Biogen MA Inc.
    Inventors: Leonid Gorelik, Kenneth J. Simon, Meena Subramanyam, Mia Marie Rushe
  • Publication number: 20220088382
    Abstract: Devices, systems and methods are disclosed for treating seizures, such as epileptic seizures, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface, such as an electrode, for contacting an outer skin surface of a patient. The stimulator is configured for coupling to a mobile device configured to receive a wireless signal. The stimulator is configured to transmit the electrical impulse through the contact surface and the outer skin surface sufficient to modulate a nerve within a patient and to ameliorate one or more symptoms of a seizure in the patient.
    Type: Application
    Filed: December 4, 2021
    Publication date: March 24, 2022
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20220079502
    Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
    Type: Application
    Filed: October 29, 2021
    Publication date: March 17, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20220062622
    Abstract: Devices, systems and methods are provided for treating post-operative symptoms following major surgery and/or for treating patients in critical or intensive care. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 60 seconds to about 5 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms are reduced. A stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. The doses may be administered before and after the patient's surgery, or while the patient is being treating in intensive care.
    Type: Application
    Filed: September 30, 2021
    Publication date: March 3, 2022
    Inventors: J. P. Errico, Bruce J. Simon, Peter Staats
  • Publication number: 20220062343
    Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 3, 2022
    Inventors: Tien Lee, Hans G. Klingemann, Barry J. Simon, Laurent Boissel
  • Publication number: 20220070042
    Abstract: According to some embodiments, a method includes selecting a length for an advanced television system committee (ATSC) 3.0 frame for transmission by a single frequency network (SFN) transmitter and aligning the SFN transmitter with a global positioning system (GPS) epoch. The method further includes storing geographical coordinates of the SFN transmitter and a corresponding SFN transmitter identification (TX ID) in a database. The method also includes encoding the SFN TX ID in a non-coherent symbol of a plurality of positioning navigation timing (PNT) symbols comprising a plurality of coherent symbols and the non-coherent symbol with orthogonal frequency-division multiplexing (OFDM) numerology to support positioning. The method further includes prepending the plurality of PNT symbols to the ATSC 3.0 frame to generate a modified ATSC 3.0 frame and transmitting the modified ATSC 3.0 using a SFN transmitter antenna of the SFN transmitter.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 3, 2022
    Applicant: Sinclair Broadcast Group, Inc.
    Inventors: Michael J. SIMON, Mark A. AITKEN, Ebenezer K. KOFI, Louis Herbert LIBIN
  • Patent number: 11260225
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: March 1, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20220046937
    Abstract: Embodiments of an outdoor cooking station with a cooking chamber configured to be heated with smoke. The outdoor cooking station includes a pivoting hood to move the hood between closed and open positions. In one embodiment, upon the hood being in the closed position, the hood includes a vertically oriented surface with openings to vent the heated smoke.
    Type: Application
    Filed: July 26, 2021
    Publication date: February 17, 2022
    Inventors: Paul J. Simon, Michael R. Giebel
  • Publication number: 20220046948
    Abstract: Described herein are egg white protein formulations, dosage containers containing the egg white protein formulations, methods of making the egg white protein formulations and dosage containers, and methods of controlling the quality of the egg white protein formulations, materials for manufacturing the egg white protein formulation (such as dried egg white protein powder), and the dosage containers. Further described herein are oral immunotherapy methods for treating an egg allergy. The method includes orally administering to the patient doses of a pharmaceutical composition comprising egg white protein according to an oral immunotherapy schedule. Also described herein are methods of adjusting a dosage of the pharmaceutical composition during oral immunotherapy if the patient experiences an adverse event related to the administration of a dose or a concurrent factor associated with increased sensitivity to an allergen that is not related to the administration of the dose.
    Type: Application
    Filed: December 17, 2019
    Publication date: February 17, 2022
    Inventors: Reyna J. SIMON, Nicholas William BIRRINGER, Matthew SANDER, Christina CAPULE, Kari Rose BROWN, Stephen G. DILLY, Daniel ADELMAN
  • Patent number: 11248040
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 15, 2022
    Assignee: TRELLIS BIOSCIENCE, LLC
    Inventors: Lawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
  • Publication number: 20220044828
    Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
    Type: Application
    Filed: September 10, 2021
    Publication date: February 10, 2022
    Inventors: Joseph P. Errico, Bruce J. Simon, Peter Staats, Thomas Errico
  • Publication number: 20220040473
    Abstract: Systems and methods for treating and/or averting cardiac arrhythmias, such as atrial fibrillation, are provided. A device comprises a housing including an energy source, a contact surface and an electrode. The energy source is configured to transmit an electrical impulse to the electrode through the outer skin surface to a vagus nerve of the patient. The electrical impulse comprises bursts of about 2 pulses to about 20 pulses with each of the bursts having a frequency of about 3 Hz to about 100 Hz. The electrical impulse modulates the vagus nerve to treat a cardiac arrhythmia of the patient. A system includes a sensor for detecting a physiological parameter of a patient's heart, such as heart rate variability, and a controller configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220023619
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent symptoms of headache in a patient. The headache may include primary headache, such as migraine and cluster headache, or secondary headache resulting from an underlying medical condition, such as post-concussion headache. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of between about 30 seconds to about 5 minutes. The electrical impulses may have a frequency of about 1 kHz to about 20 kHz.
    Type: Application
    Filed: August 16, 2021
    Publication date: January 27, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 11230601
    Abstract: Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-?1 and are characterized by particular functional features, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: January 25, 2022
    Assignee: Tilos Therapeutics, Inc.
    Inventors: Barbara S. Fox, Randall Burton, Stavros Kopsiaftis, Xiufeng Song, Patricia Rao, Kenneth J. Simon, Jessie M. English
  • Patent number: 11229790
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat epileptic seizures by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 25, 2022
    Assignee: electroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20220017612
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 20, 2022
    Inventors: Randall Burton, Jessie M. English, Barbara S. Fox, Stavros Kopsiaftis, Yacob Gomez Llorente, Renee Moore, Patricia Rao, Giovanna Scapin, Kenneth J. Simon, Haihong Zhou
  • Patent number: 11224310
    Abstract: Disclosed is an induction burner ignition system that implements an induction burner located external to the fire pot. The induction burner can be controlled by a controller to start and stop according to a predetermined heating algorithm, and can further provide heat via heat sinks in contact with the induction burner. Because the induction burner is located external to the fire pot, it is easily repairable or replaceable and avoids the harmful atmosphere of the fire pot. The induction burner also provides more uniform heating than conventional hot rod technology to improve the pellet heating process.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: January 18, 2022
    Assignee: Dansons US, LLC
    Inventors: Paul J. Simon, Michael R. Giebel