Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts of about 2 to about 20 pulses and the pulses oscillate between a positive voltage and a negative voltage within each burst.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: Provided herein are methods, tools, devices and systems for treating, enhancing and improving spatial and temporal neurocognitive processing abilities and associated neuromotor activities of a subject, including a subject suffering from a neurocognitive disorder or condition such as a stroke, brain injury or genetic disorder.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a vagus nerve. The system comprises a handheld stimulator including a housing having a contact surface for contacting an outer skin surface of a patient. The housing is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal. An energy source is coupled to the stimulator and the mobile device. The energy source is configured to generate an electric field that transmits an electric current through the contact surface and the outer skin surface to modulate a nerve within the patient and thereby treat a medical condition of the patient.

Abstract: An example method of mapping a plurality of modulation symbols of a plurality of physical layer pipes present in a frame to a resource grid of data cells for the frame is described. The modulation symbols of the plurality of physical layer pipes are represented by a two-dimensional array comprising the modulation symbol values for the plurality of physical layer pipes and the resource grid of data cells is represented by a one-dimensional sequentially indexed array.

Abstract: An extensible communication system is described herein. The system includes a first module for receiving a root index value and for generating a constant amplitude zero auto-correlation sequence based on the root value. The system further includes a second module for receiving a seed value and for generating a Pseudo-Noise sequence based on the seed value. The system further includes a third module for modulating the constant amplitude zero auto-correlation sequence by the Pseudo-Noise sequence and for generating a complex sequence. The system further includes a fourth module for translating the complex sequence to a time domain sequence, wherein the fourth module applies a cyclic shift to the time domain sequence to obtain a shifted time domain sequence.

Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.

Abstract: Techniques are disclosed relating to generating and receiving radio frames with multiple portions that have different encoding schemes. An apparatus may include one or more processing elements configured to receive, via a wireless radio, wireless data that includes a plurality of portions that each include multiple orthogonal frequency-division multiplexing (OFDM) symbols. Different ones of the portions have different frequency transform sizes and different sampling rates. The wireless data may also include control data that indicates the frequency transform sizes and sampling rates for the ones of the portions. The apparatus may select, based on the control data and a determined velocity of the apparatus, one or more but not all of the plurality of portions and may decode the selected one or more portions to determine data represented by the OFDM symbols in the selected one or more portions. Different portions of the wireless data may be adapted for decoding by devices moving at different maximum velocities.

Abstract: Systems, methods, and storage media for operating a wireless device are disclosed. Exemplary implementations may: select a consumer to provide feedback related to one or more transactions associated with the consumer; transmit, for display on a wireless device of the consumer, a survey comprising one or more questions related to the one or more transactions associated with the consumer; select an incentive offer from an incentive offer database; transmit, for display on the wireless device of the consumer, information related to the incentive offer; receive one or more responses to the survey; and fulfil the incentive offer.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that applies an electrical impulse transcutaneously through an outer skin surface of the patient. The electrical impulse includes pulses having a frequency of about 1 kHz to about 20 kHz. The device housing may transmit data to or from a patient interface device, such as a mobile phone or computer, relating to the stimulation parameters. The interface device in turn may communicate with a database contained within other computers, via a network or the internet.

Abstract: Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.

Abstract: Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface for contacting an outer skin surface of a patient and a pulse generator coupled to the contact surface. The pulse generator is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The pulse generator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: An extensible communication system is described herein. The system includes a first module for receiving a root index value and for generating a constant amplitude zero auto-correlation sequence based on the root value. The system further includes a second module for receiving a seed value and for generating a Pseudo-Noise sequence based on the seed value. The system further includes a third module for modulating the constant amplitude zero auto-correlation sequence by the Pseudo-Noise sequence and for generating a complex sequence. The system further includes a fourth module for translating the complex sequence to a time domain sequence, wherein the fourth module applies a cyclic shift to the time domain sequence to obtain a shifted time domain sequence.

Abstract: A method for operating a transmitting device to communicate with a receiving device is described herein. The method includes the step of the transmitting device selecting a root index value from a set of root index values. The method further includes the step of the transmitting device generating a frequency domain Constant Amplitude Zero Auto-Correlation sequence based on the selected root index value. The method further includes the step of the transmitting device modulating the Constant Amplitude Zero Auto-Correlation sequence by a pseudo-noise sequence. The method further includes the step of the transmitting device generating an Orthogonal Frequency Division Multiplexing symbol, wherein the frequency domain Constant Amplitude Zero Auto-Correlation sequence modulated by the pseudo-noise sequence defines subcarrier values for the Orthogonal Frequency Division Multiplexing symbol.

Abstract: This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

Abstract: Systems, methods, and storage media for operating a wireless device are disclosed. Exemplary implementations may: select a consumer to provide feedback related to one or more transactions associated with the consumer; transmit, for display on a wireless device of the consumer, a survey comprising one or more questions related to the one or more transactions associated with the consumer; select an incentive offer from an incentive offer database; transmit, for display on the wireless device of the consumer, information related to the incentive offer; receive one or more responses to the survey; and fulfil the incentive offer.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a vagus nerve. The system comprises a handheld stimulator including a housing having a contact surface for contacting an outer skin surface of a patient. The housing is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal. An energy source is coupled to the stimulator and the mobile device. The energy source is configured to generate an electric field that transmits an electric current through the contact surface and the outer skin surface to modulate a nerve within the patient and thereby treat a medical condition of the patient.