Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma. The invention provides methods of treating cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma), methods of determining whether a patient suffering from cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma) is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma) to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from cancer (e.g.

Abstract: A workpiece bending press has a vertical ram with a lateral through-hole near the bottom. A first elongated mandrel has an end that mounts in the through-hole. The first mandrel mounting end has a cavity that receives an end of a second mandrel. The first mandrel then extends from a first side of the ram, and the second mandrel extends from the opposite side of the ram. Workpiece forming blocks may be placed under each mandrel, providing two different mandrels and forming blocks on the ram at once for different pressing stages or different workpiece diameters. One or both mandrels may be part of a set of interchangeable mandrels with different outer diameters. The ram may be operated by a lever that is quickly movable to the left or right side of the press for convenient use of mandrels extending from the left and right sides of the ram.

Abstract: Embodiments of the invention provide an apparatus for preparing a surface that includes an elongated handle and a head portion removably securable to the elongated handle via a pivot joint, the head portion being adapted to receive a surface preparation material and being capable of pivotal movement relative to the elongated handle. The apparatus is configured to allow the elongated handle to remain substantially perpendicular to the head portion without any external support.

Abstract: The systems, methods, and apparatuses provided herein disclose interpreting a performance criteria for a vehicle, wherein the performance criteria is indicative of a desired operating parameter for the vehicle; interpreting a good driver definition value indicative of a good driver profile for the interpreted performance criteria; determining a performance value indicative of how an operator of the vehicle is performing with respect to the good driver definition value; and in response to the performance value indicating that the vehicle is not satisfying the performance criteria, managing an actuator output response value for at least one actuator in the vehicle to facilitate achievement of the good driver definition value.

Abstract: A cooling system for cooling electronic aircraft equipment comprises a primary cooling arrangement configured to provide basic cooling energy for cooling the electronic aircraft equipment and a supplemental cooling arrangement configured to provide supplemental cooling energy for cooling the electronic aircraft equipment. The supplemental cooling arrangement comprises a coolant supply system and a coolant distribution system. The coolant supply system is configured to supply a compressed coolant to the electronic aircraft equipment to be cooled, and the coolant distribution system is configured to selectively direct the compressed coolant supplied by the coolant supply system to at least one of a plurality of components of the electronic aircraft equipment.

Abstract: A system includes a ground based area, an electromagnetic (EM) interrogation device having an EM emitter that directs an EM beam at the ground based area. The EM interrogation device includes a detector array that receives reflected EM radiation from the EM beam, and a controller having a ground movement description module that determines a movement profile of the ground based area in response to the reflected EM radiation.

Abstract: A method producing a dynamic single dimensional output image from a two dimensional image is disclosed. A camera captures a digital image. In the method, each row of pixels of the input image may be read progressively to generate lighting instructions corresponding to each row. The instructions are sent to e.g. programmable LEDs. The process continues with a first row of pixels from the input image being processed first, followed by processing of a subsequent row of pixels of the input image. Upon processing of the second row of pixels, LEDs of the LED strip are illuminated correspondingly. This process continues iteratively until the final row of pixels of the input image. If the imaged object varies visually from one side to another or from top down, the LEDs illuminated by processing of each row of pixels will vary, thereby generating a dynamic image.

Abstract: Methods of evaluating tumor mutational burden in a sample, e.g., a tumor sample or a sample derived from a tumor, from a subject, are disclosed.

Abstract: A method includes operating a spark ignition engine and flowing low pressure exhaust gas recirculation (EGR) from an exhaust to an inlet of the spark ignition engine. The method includes interpreting a parameter affecting an operation of the spark ignition engine, and determining a knock index value in response to the parameter. The method further includes reducing a likelihood of engine knock in response to the knock index value exceeding a knock threshold value.

Abstract: The systems, methods, and apparatuses provided herein disclose interpreting a performance criteria for a vehicle, wherein the performance criteria is indicative of a desired operating parameter for the vehicle; interpreting a good driver definition value indicative of a good driver profile for the interpreted performance criteria; determining a performance value indicative of how an operator of the vehicle is performing with respect to the good driver definition value; and in response to the performance value indicating that the vehicle is not satisfying the performance criteria, managing an actuator output response value for at least one actuator in the vehicle to facilitate achievement of the good driver definition value.

Abstract: Systems and methods for coating a metallic component are provided. In one embodiment, a metallic coating may be disposed in a plating bath comprising AlBr3. The metallic coating may be coupled with, or configured as, a working electrode. A counter electrode formed of aluminum may be disposed within the plating bath. An electric current may be applied between the two electrodes resulting in the electrodeposition of aluminum on the metallic component. In one particular embodiment, the plating bath may include LiBr, KBr and CsBr, with AlBr3 being present in an amount of approximately 80 percent or greater by weight. Various types of metals may be coated with aluminum using embodiments of the present disclosure. Additionally, the methods and systems described herein are amenable to coating of complex geometries.

Abstract: A system and method of detecting fueling imbalance(s) in an internal combustion engine is provided. The method includes receiving data regarding an oxygen content of engine exhaust for the engine operating at a cycle rate. Frequency component analysis is performed comprising a filtering operation on the received oxygen content data. The filtering is done at the cycle rate of the engine or harmonics thereof to obtain filtered oxygen content data. Then, the method/system determines at least one of: 1) one or more angles of the engine at which the filtered oxygen content data exhibits a first amplitude value characteristic relative to amplitude values at other angles; and 2) a shape of the filtered oxygen content data obtained by sampling at pre-defined engine angles. The method/system then identifies a cylinder experiencing a fueling imbalance responsive to the determined at least one of one or more angle(s) and shape of the data.

Abstract: A method includes operating a spark ignition engine and flowing low pressure exhaust gas recirculation (EGR) from an exhaust to an inlet of the spark ignition engine. The method includes interpreting a parameter affecting an operation of the spark ignition engine, and determining a knock index value in response to the parameter. The method further includes reducing a likelihood of engine knock in response to the knock index value exceeding a knock threshold value.

Abstract: One exemplary embodiment is a system comprising a multi-fuel engine structured to selectably combust varying proportions of a first type of fuel and a second type of fuel, and an electronic control system structured to control the provision of at least one of the first type of fuel and the second type of fuel to the engine using a multi-factor cost optimization. The multi-factor cost optimization may account for a plurality of factors including one or more environment factors, location factors, mission factors, warranty factors, operator-specified factors and/or fleet-specified factors.

Abstract: A scanner is integrated into a Point-Of-Sale (POS) terminal; the scanner provides scanning information during POS transactions over a POS connection and provides a server interface for connecting and communicating with an external and remote connected device independent of the POS connection.

Abstract: A scanner is integrated into a Point-Of-Sale (POS) terminal; the scanner provides scanning information during POS transactions over a POS connection and provides a server interface for connecting and communicating with an external and remote connected device independent of the POS connection.

Abstract: A scanner is integrated into a Point-Of-Sale (POS) terminal; the scanner provides scanning information during POS transactions over a POS connection and provides video capabilities over a separate and independent network connection.

Abstract: A surgical tissue connector system for moving a first internal body tissue to a position away from a second internal body tissue and then holding the first internal body tissue in the position. Tissue connectors are secured to cords such that the length of cord between the tissue connectors can be easily adjusted in a laparoscopic work space.

Abstract: A cooling system for cooling electronic aircraft equipment comprises a primary cooling arrangement configured to provide basic cooling energy for cooling the electronic aircraft equipment and a supplemental cooling arrangement configured to provide supplemental cooling energy for cooling the electronic aircraft equipment. The supplemental cooling arrangement comprises a coolant supply system and a coolant distribution system. The coolant supply system is configured to supply a compressed coolant to the electronic aircraft equipment to be cooled, and the coolant distribution system is configured to selectively direct the compressed coolant supplied by the coolant supply system to at least one of a plurality of components of the electronic aircraft equipment.

Abstract: An apparatus includes an initial planning module, a tandem implementation module, and a scheduler module. The initial planning module is structured to interpret one or more fleet delivery requirements, assets, drivers, and vehicle descriptions. The tandem implementation module is structured to determine a travel schedule with respect to a first vehicle and a second vehicle that enables the first vehicle and the second vehicle to travel in tandem for a least a portion of a route in response to input from the initial planning module. The scheduler module is structured to provide a fleet delivery schedule to the first vehicle and the second vehicle in response to the determination of the tandem implementation module.