Abstract: Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

Abstract: Embodiments relate to multi-cycle signal identification for static timing analysis. An aspect includes identifying, in a circuit under test, a multi-cycle signal, the multi-cycle signal having a longer period than a main clock signal of the circuit under test. Another aspect includes mapping a plurality of additional signals of the circuit under test onto the multi-cycle signal, the plurality of additional signals each having a shorter period than the multi-cycle signal. Yet another aspect includes performing static timing analysis of the circuit under test based on the multi-cycle signal.

Abstract: Immunogenic compositions and vaccines against Plasmodial infection comprising an Rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are Rh5 polypeptides or fragments or variants thereof capable of binding CD147 and conferring protection against infection and/or disease caused by multiple Plasmodial strains or Plasmodial species, inhibitors of the interaction between Rh5 and CD147 and methods for producing polypeptides in a mammalian expression system.

Abstract: Systems and methods are disclosed for parallel match processing of network packets to identify data for masking or other actions. In part, the disclosed embodiments receive packets and identify packet data, such as sensitive data, by rapid parallel matching of packet data being communicated in multi-byte wide data paths to match parameters in order to generate match vectors. The match vectors are then used to generate control vectors that are subsequently used by packet processing circuitry to perform desired actions for this packet data (e.g., mask data) and/or for related packets (e.g., drop packets). For example, data identified through the match processing can be masked, and control vectors can be mask control vectors applied to parallel multiplexers. In certain embodiments, the parallel data multiplexers are controlled by the mask control vectors to selectively output either original packet data or mask data that obscures original packet data.

Abstract: This disclosure relates to a block copolymer composition comprising a tetra-branched block copolymer (IV) having a true number average molecular weight of 40,000 to 120,000 represented by the general formula (A-B)4X; a tri-branched block copolymer (III) having a true number average molecular weight of from 30,000 to 90,000 represented by the general formula (A-B)3X; di-branched block copolymer (II) having a true number average molecular weight of from 20,000 to 60,000 represented by the general formula (A-B)2X; and a linear diblock copolymer (I) having a true number average molecular weight of from 10,000 to 30,000 represented by the general formula A-B; where A represents a polymer block of a mono alkenyl arene; B represents a polymer block of a conjugated diene, wherein the B has a true number average molecular weight ranging from 7,000 to 20,000 g/mol; and X represents the residue of an alkoxy silane coupling agent.

Abstract: An apparatus includes acoustic equipment and an enclosure to support the acoustic equipment. The enclosure includes a front cover member, a middle cover member, a back cover member, and a hinge to connect the front cover member to the back cover member. The hinge enables the movement of the front cover member and the back cover member between an open position and a closed position. The middle cover member is disposed between the front cover member and the back cover member, with the middle cover member being connected to the hinge to enable movement of the middle cover member and the back cover member between an open position and a closed position. The enclosure further includes a first latch configured to releasably secure the middle cover member to the back cover member, and a second latch configured to releasably secure the front cover member to the back cover member.

Abstract: A multistage syringe includes a first barrel, a second barrel, a second barrel seal assembly, and a plunger assembly. The first barrel includes a first barrel channel and the second barrel includes a second barrel channel. The first barrel couples to the second barrel such that the first barrel channel aligns with the second barrel channel along a central axis. The plunger assembly includes a plunger coupled to a plunger handle. The plunger slidably couples with the first barrel channel along the central axis and the second barrel seal assembly slidably couples with the second barrel channel along the central axis. The plunger and the second barrel seal assembly cooperate to maintain a seal as the plunger transitions between a distal end of the multistage syringe and a proximal end of the multistage syringe.

Abstract: Methods, apparatus, computer programs, and non-transitory computer readable storage mediums for repairing an aerofoil of a gas turbine engine A method of repairing an aerofoil of a gas turbine engine, the method comprising: controlling machining of at least one of: a first aerofoil and a second aerofoil; the machining causing an increase in a throat area defined by the first aerofoil, the second aerofoil, a first platform and a second platform, the first aerofoil and the second aerofoil being arranged to couple to the first platform and to the second platform; and controlling provision of a coating to at least one of the first platform and the second platform subsequent to controlling machining to reduce the throat area.

Abstract: Certain embodiments of the present invention provide an apparatus for closing off an opening above, below, or between electronic equipment in a rack. The rack includes a pair of equipment rails. The electronic equipment is mounted to the equipment rails. The apparatus includes a base, a roller shade, and a handle. The roller shade is rotatably connected to the base and includes a free end extending from the base when the roller shade is rotated. The handle is connected to the free end of the roller shade. The base is removably connected to the equipment rails at a first position. The handle is removably connected to the equipment rails at a second position spaced apart from the first position such that the free end of the roller shade is extended to close off the opening in the rack.

Abstract: In some aspects, the invention relates to a porous implant, comprising a resorbable or bio-erodible porous silicon-based carrier material; a reservoir formed within the body of the porous silicon-based carrier material; and a beneficial substance disposed within the reservoir.

Abstract: A cap configured to cover a terminal of a battery includes a base and a top having a plug and a cavity. The cavity is configured to receive the terminal and the plug is configured to retain the top on the terminal. A tether has a first end fixed to the base and a second end fixed to the top and connects the top to the base. The base is configured to retain the top to the terminal when the top is both connected to the terminal and separate from the terminal.

Abstract: A method for managing data communication between a communication device (102) and another device (112) in a communication network, comprises providing (500) data for transmission by the communication device (102), and controlling by at least one secure management element (300, 304) operating in a secure environment (218) in the communication device the transmission of the provided data by the communication device so as to manage data transmitted by the communication device. The step of controlling may include at least one of controlling an amount of data transmitted, controlling a time of transmission of data and controlling a periodicity of transmission of data. A communication device and a method of managing data received by a communication device are also described.

Abstract: Multiple LRSWs are launched to place at least one follower LRSW in a trailing position to at least one lead LRSW in a lead wave. Knowledge of the target space and particularly the primary target gained by the lead LRSWs is transmitted to the follower LRSWs (either directly or via another communication platform such as a satellite or UAV) and incorporated by the follower LRSWs to inform target selection. The follower LRSWs in the following wave trail the lead LRSWs in the lead wave with sufficient spacing in time and distance to inform target selection and with range remaining to maneuver to the selected target. This knowledge may be transmitted back to another follower LRSW (together with any data acquired the initial follower LRSW) and so forth in a “string” of LRSWs to inform target selection and maneuver the LRSWs to the primary target or an alternate target.

Abstract: An apparatus and method for attaching a crawler vehicle to the surface of an object. The crawler vehicle may comprise a frame, a number of moveable surface-engaging components attached to the frame, a number of actuators, and an electro-permanent magnet. The number of actuators is operable to move the frame with respect to the object when the number of moveable surface-engaging components is in contact with the surface of the object. The electro-permanent magnet is operable to hold the number of moveable surface-engaging components in contact with the surface of the object by a magnetic force between the electro-permanent magnet and the object when the electro-permanent magnet is activated and to remove the magnetic force when the electro-permanent magnet is deactivated to release the number of moveable surface-engaging components from the surface of the object.

Abstract: Systems and methods are described for enabling a user to bias the type of media content made available to a user account through a localized content dashboard. In one implementation, a method for adjusting media content availability associated with a user account configured to receive media content from a server system over a network, includes displaying on a content playback system a localized content dashboard, including: a summary of attributes of media content accessed by the user account, where the summary of the attributes is based on metadata associated with the accessed media content; and controls for biasing the attributes of media content delivered to the user account. The content playback system receives data corresponding to user input actuating one of the controls; and in response to receiving the data, transmits over the network to the server system data associated with the media content attribute biased by the user input.

Abstract: A cylindrical lockset comprises a multiple-compartment lock cage subassembly. A retractor is housed within a middle lock cage compartment. Spindle return torsion springs, for biasing corresponding handle-carrying spindles to their default positions, are housed within axially adjacent lock cage compartments. A torque plate transfers torque from the lock cage subassembly to relatively radially distal trim posts. A knob catch assembly seated in each handle-carrying spindle comprises a generally elliptically-shaped wrap around catch spring and a knob catch backup washer to resist axial loads produced by efforts to pull a handle off of the spindle. A key spindle provides a dog travel window defined by a closed, continuous edge of the key spindle, which window is positioned opposite of an axially-extending seam of the key spindle.

Abstract: Systems and methods for dynamically and automatically generating short-form versions of long-form media content are provided. The long-form media content may be tagged with metadata indicating objects or actions in frames, scenes, portions of scenes, or other units of the media content. The systems and methods may receive a user-specified time limit and use the metadata to create a short-form version of the long-form media content (using one or more of the scenes, portions of scenes, or other units of the media content), which preserves one or more story arcs within the media content.

Abstract: A software and hardware facility persistently maintains metrics on directories at different levels within a tree of a filesystem. The facility hierarchically aggregates attributes of files contained by directories and stores them as metric values in each directory within a tree. The stored values represent summed or otherwise aggregated data from the descendant directories and files. The metric values represent aggregated attributes such as checksums, MIN and/or MAX aggregates, sameness bits, bloom filter aggregates, queryable user tags, moving average aggregates, b-tree aggregates, etc. The facility provides mechanisms for efficiently sampling activities performed by the filesystem and visually representing these activities.

Abstract: A composition is disclosed, comprising a block copolymer, at least one homopolymer or copolymer of butene, and at least one olefin homopolymer or copolymer, wherein said block copolymer has hydrogenated low-vinyl polybutadiene end blocks with a specific gravity>0.85 g/cc, and a controlled distribution midblock of polyalkenyl arene/hydrogenated diene. Although the block copolymer has a preferred linear structure as a triblock copolymer, it may also be branched or radial coupled copolymer that has at least 2 arms or more. The composition is useful for rotational molding, slush molding, injection molding, extrusion or compression molding, or thermoforming or calendering for making articles that are resistant to chemicals such as diesel fuel, for the automotive market, for example. The MFR of the block copolymer is 1 to about 50 g/10 min. at 230° C., with a wt. of 2.16 kg.

Abstract: An integrated circuit (IC) device can include at least one phase or delay lock loop (P/DLL) circuit comprising a plurality of circuit sections, at least one of the circuit sections responsive to digital calibration values to alter at least one periodic output signal; a nonvolatile memory (NVM) circuit formed in the same IC package as the at least one P/DLL circuit and configured to store the calibration values; and a processing circuit formed in the same IC package as the at least one P/DLL circuit and the NVM circuit, the processing circuit configured to generate the calibration values in response to target values and output values from the at least one P/DLL circuit, and to store the calibration values in the NVM circuit.