Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: A sideband communication system has been developed for a conveyor system. A controller card controls the operation of a conveyor zone and communicates information about each conveyor in the conveyor zone. The controller card is assigned to control and monitor the operation of one or more of these zones of conveyors. The cards of adjacent zones are daisy-chained together to facilitate communication with one another and with other systems like a programmable logic controller (PLC). In addition to the standard controller area network (CAN) communication protocol, the controller cards further communicate amongst themselves using a sideband communication protocol that is outside the realm of the standard CAN communication protocol. The sideband communication protocol allows the cards to communicate with each other without interfering with normal network communications which provides additional capabilities such as automatic card self-identification.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Provided is a fuel design configured to have a thickness that is equal to or less than a mean-free path of electrons emitted by a radioactive energy source to prevent electrons produced thereby from being stopped within the fuel design and thus decreasing the intensity of bremsstrahlung radiation generated within the fuel design. Additionally provided is a two-phase shielding system including a first shield formed of a first material having a thickness exceeding a mean-free path of an electron emitted from a radioactive source material so as to prevent the electron from passing through the first shield, and a second shield formed of a second material configured to prevent bremsstrahlung radiation generated by the electron from passing through the second shield.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Systems and methods are provided to monitor vital signs from a plurality of subjects simultaneously and in real-time. The systems and methods can utilize visible video signal or infrared (IR) video signals, or both, defining respective sequences of frames representative of a scene including the plurality of subjects. The systems and methods can analyze digital images corresponding to respective frames in a sequence of frames to generate a time series of image values. In an aspect, the systems and methods can analyze the time series to identify a characteristic frequency representing a value of a vital signal that is oscillatory in nature.

Abstract: Systems and methods for generating one or more candidate maintenance windows of at least one cell site of a telecommunications network include a user device and a cell site communicatively coupled to a service management system. The service management system is structured to receive a maintenance request to upgrade the cell site, the maintenance request including a maintenance requirement. The service management system is structured to aggregate one or more network parameters based on the cell site and generate one or more candidate maintenance windows based on the one or more network parameters aggregated and the maintenance requirement. The one or more candidate maintenance windows identify one or more downtime upgrade periods correlating to the cell site.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Technologies for identifying prospective marketing targets based on payment vehicle-based payment transactions processed over electronic payment networks are disclosed. Payment vehicle-based payment transactions are analyzed to determine historical purchase activity progressions. Consumer behavior can be mapped to a historical purchase activity progression so that future spend behavior of the consumer can be identified.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Systems and methods are disclosed for providing an account holder with an incentive-consent matrix at a point-of-sale device of a merchant. The account holder can provide consent to store transaction related data and obtain an incentive in exchange. The incentive out be a coupon or other offering associated with the merchant. Varying levels of consent can be offered, with each level associated with an incentive having a different relative value. The transaction data can subsequently be provided to a recipient in accordance with the consent received from the account holder.

Abstract: Technologies for determining spending behavior of a consumer in a category of interest are disclosed. The spending behavior is based on tracking payment vehicle transactions across a number of merchants. Temporal and geographic parameters are considered to determine if a payment vehicle transaction falls within the category of interest. Based on the payment vehicle transactions and the temporal and geographic parameters, Share of Wallet (SOW) can be determined.

Abstract: Provided herein is a method for fabricating a heat source for a radioisotope thermoelectric generator (RTG). The method may include reducing a particle size in a strontium compound by powdering and sieving the strontium compound and/or dissolving the strontium compound into an aqueous solution; mixing the strontium compound with graphite to obtain a strontium-graphite mixture; performing a press to the strontium-graphite mixture; and encapsulating the pressed strontium-graphite mixture into an x-ray shielding to obtain the heat source.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are compounds that inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HDAC6-related diseases and disorders (e.g., Alzheimer's disease, cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: The disclosed computer-implemented method may include a process for monitoring and improving end-to-end video quality based on scaled and/or interpolated perceptual quality scores across various video views. The method may also include a process for improving search experience for user expectations. Additionally, the method may include a process for providing hardware virtualization and simulation for server hosting. Furthermore, the method may include a process for filtering network traffic in a hosting environment. The method may additionally include a process for testing applications in a hosting environment. The method may further include a process for supporting multi-touch applications. The method may also include a process for optimized graphics rendering. Various other related methods and systems are also disclosed.

Abstract: Systems and methods for applying a promotion to a payment transaction originating at a point of sale system of a merchant are described. Transactional information is provided to an acquirer computing system of the merchant. Based on identifying indicia associated with the transactional information, the acquirer computing system determines whether to modify the payment transaction messaging before communicating it along to an issuer computing system.