Abstract: A radiotherapy device includes an electron source, a first beam corrector, a drift tube, a target with target material that when impacted by an electron beam generates Bremsstrahlung x-ray photons, and a radiosurgical needle. The radiosurgical needle has an elongated radiopaque needle body with a lumen and a pointed tip for piercing a tissue of a patient. The target is positioned within the lumen of the radiosurgical needle. A first beam steering device steers a focused electron beam within the micro drift tube to the target. A radiotherapy system and a method for conducting radiotherapy are also disclosed.

Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose. Instead, a radiation procedure can be weighted to deliver certain amounts of radiation per day through temporal feathering. A target volume for a radiation procedure can be determined based on at least one image. The radiation procedure includes a total dose of radiation to be administered in a time period. An organ outside of the target volume at risk of acute toxicity from the radiation procedure can be determined based on the at least one image. A sequence plan that ensures the total dose of radiation is administered in the time period can be calculated. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation. The sequence accomplishes temporal feathering of the radiation therapy procedure.

Abstract: An automated therapeutic device and methods thereof for heating and extending a patients curled fingers is provided. The device includes a rigid base extending from a patients hand to elbow, a plurality of fingerlets, each operable to attach to a finger of the patient, a plurality of extending elements, each extending element operable to reversibly attach to the rigid base and reversibly attach to one of the plurality of fingerlets, and a heating element operable to reversibly attach to the rigid base and distribute heat along the patient's anterior forearm.

Abstract: An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.

Abstract: Provided herein are compositions, systems, and methods for prediction of a chemosensitivity to cisplatin or other platinum based drugs for cancer. In certain embodiments, the methods comprise receiving results of, or conducting, an mRNA and/or protein expression level analysis of at least one gene (e.g., 1-13 or 1-19 genes) in a tumor sample from a subject, wherein the gene is expressed at higher levels than a control and is selected from: ADA, NPM3, CSTA, KRT5, KRT14, ATP1B3, USP31, MAP7D3, LRRC8C, C15orf41, LY6K, BNC1, SLFN11, ADAT2, CDIN1, C1QBP, CDC7, CDCA7, FKBP14, MMP10, PSAT1, RIOK1, STOML2, WDR3, and ZNF750; and treating said subject with Cisplatin or other platinum based cancer drug.

Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose. Instead, a radiation procedure can be weighted to deliver certain amounts of radiation per day through temporal feathering. A target volume for a radiation procedure can be determined based on at least one image. The radiation procedure includes a total dose of radiation to be administered in a time period. An organ outside of the target volume at risk of acute toxicity from the radiation procedure can be determined based on the at least one image. A sequence plan that ensures the total dose of radiation is administered in the time period can be calculated. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation. The sequence accomplishes temporal feathering of the radiation therapy procedure.

Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose by temporally feathering the radiation procedure. Using temporal feathering, the radiation procedure delivers a total amount of radiation that is weighted amounts of radiation per day. The weighted amounts of radiation can be delivered according to a sequence plan that ensures the total dose of radiation is administered in the time period. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation.

Abstract: An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.

Abstract: A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a method and apparatus is provided for creating data objects from one or more digital images captured by a mobile device. A computing device receives a first digital image file comprising first image metadata, wherein the first image metadata includes one or more image properties each having an image property value. The computing device transforms one or more of the image property values of the one or more image properties into one or more particular values. The computing device populates one or more data object property values of a data object with the one or more particular values. The computing device stores the data object in a data repository.

Abstract: An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.

Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose. Instead, a radiation procedure can be weighted to deliver certain amounts of radiation per day through temporal feathering. A target volume for a radiation procedure can be determined based on at least one image. The radiation procedure includes a total dose of radiation to be administered in a time period. An organ outside of the target volume at risk of acute toxicity from the radiation procedure can be determined based on the at least one image. A sequence plan that ensures the total dose of radiation is administered in the time period can be calculated. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation. The sequence accomplishes temporal feathering of the radiation therapy procedure.

Abstract: A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a method and apparatus is provided for creating data objects from one or more digital images captured by a mobile device. A computing device receives a first digital image file comprising first image metadata, wherein the first image metadata includes one or more image properties each having an image property value. The computing device transforms one or more of the image property values of the one or more image properties into one or more particular values. The computing device populates one or more data object property values of a data object with the one or more particular values. The computing device stores the data object in a data repository.

Abstract: A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a method and apparatus is provided for creating data objects from one or more digital images captured by a mobile device. A computing device receives a first digital image file comprising first image metadata, wherein the first image metadata includes one or more image properties each having an image property value. The computing device transforms one or more of the image property values of the one or more image properties into one or more particular values. The computing device populates one or more data object property values of a data object with the one or more particular values. The computing device stores the data object in a data repository.

Abstract: Systems and methods are provided for analyzing entity performance. In one implementation, a method is provided that includes recognizing an identifier associated with an entity and accessing a data structure comprising information associated with a plurality of interactions. The method also comprises identifying one or more interactions of the plurality of interactions based on the recognized identifier. The method further comprises processing the information of the identified interactions to analyze a performance of the entity and providing the processed information to display the performance of the entity on a user interface.

Abstract: Systems and methods are provided for analyzing entity performance. In one implementation, a method is provided that includes recognizing an identifier associated with an entity and accessing a data structure comprising information associated with a plurality of interactions. The method also comprises identifying one or more interactions of the plurality of interactions based on the recognized identifier. The method further comprises processing the information of the identified interactions to analyze a performance of the entity and providing the processed information to display the performance of the entity on a user interface.

Abstract: An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.

Abstract: A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a method and apparatus is provided for creating data objects from one or more digital images captured by a mobile device. A computing device receives a first digital image file comprising first image metadata, wherein the first image metadata includes one or more image properties each having an image property value. The computing device transforms one or more of the image property values of the one or more image properties into one or more particular values. The computing device populates one or more data object property values of a data object with the one or more particular values. The computing device stores the data object in a data repository.

Abstract: A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a method and apparatus is provided for creating data objects from one or more digital images captured by a mobile device. A computing device receives a first digital image file comprising first image metadata, wherein the first image metadata includes one or more image properties each having an image property value. The computing device transforms one or more of the image property values of the one or more image properties into one or more particular values. The computing device populates one or more data object property values of a data object with the one or more particular values. The computing device stores the data object in a data repository.

Abstract: Systems and methods are provided for analyzing entity performance. In one implementation, a method is provided that includes receiving a request with one or more filter selections and accessing a data structure comprising a plurality of categories of information showing interactions associated with multiple entities. The method also comprises identifying a set of categories of the plurality of categories within the data structure based on the one or more filter selections. The method further comprises processing the information of the identified categories to analyze a performance of one or more entities of the multiple entities in accordance with the one or more filter selections and providing the processed information to display the performance of the one or more entities on a user interface.

Abstract: A computer-based method and system for sharing and deconflicting data changes amongst a plurality of replication sites. In a particular embodiment, data changes at sites to data objects are tracked by each site on a per-data object basis using per-data object version vectors. In another particular embodiment, data changes at sites to links connecting two data objects are tracked by each site on a per-link set basis using per-link set version vectors. In another particular embodiment, per-object version vectors are used to detect a conflict resulting from concurrent changes at two or more sites in which one of the concurrent changes includes an object resolution change.