Abstract: A compound according to formula (I) wherein R1 is hydrogen, cyclopropyl, or pyrazolyl, wherein said pyrazolyl is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, Ri does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: A bag with integral legs. The bag includes a base with sidewalls forming a main compartment with an interior volume. A pair of legs is attached to a lower side of the base and configured to pivot between a stowed position and an extended position. In the extended position, the bag is supported off of a ground surface at a desired height. Additionally, the bag includes a tray configured to extend outwardly from the bag, providing a convenient work surface for a user. The bag may further include a lower pocket adapted to fully enclose the pair of legs therein when the pair of legs is in the stowed position. Some embodiments include a locking hinge to lock each of the pair of legs either in a stowed or in an extended position, offering additional stability to the bag when in an elevated position.

Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

Abstract: A method of managing identities for use in a mobile telecommunications device in a telecommunications network has the following features. The identity management process is triggered and one or more parameters of a currently available mobile telecommunications network detected. An identity database is searched—each record in the identity database comprises an identity and additional identity information for each identity. The additional identity information includes the one or more parameters. The identity management process involves selecting an identity when a first record comprising the one or more parameters detected is found in said searching and modifying an active identity of the mobile telecommunications device to be the selected identity when the active identity is not already the selected identity. This process can be carried out by a subscriber information module of a mobile telecommunications device.

Abstract: Disclosed is an artists' watercolour paint composition comprising, at least one pigment; one or more humectants; a binder selected from one or more alkali soluble polymers; and a pH stabilizer in an amount effective to adjust the mixture to an alkali pH so that the watercolour paint composition is water soluble. Also disclosed are uses of the paint composition in providing watercolour paintings.

Abstract: According to aspects of the invention there is provided a remote unit comprising a processor and one or more terminal interfaces, the processor being connected to the one or more terminal interfaces, the terminal interfaces configured for coupling with a set of terminals, wherein the processor is configured to perform quality of service network testing using one or more of the set of terminals over one or more communication networks.

Abstract: Various orthotic joint devices, components, and methods are provided. These include orthotic joint alignment devices for adjusting a neutral or fixed angle of an orthotic joint device independently of other parameters, orthotic joint devices providing staged resistance through staged recruitment of separate springs or initiation of staged spring-rate behavior of a single spring retained in a joint body, adapters for converting non-staged resistance orthotic joint devices into orthotic joint devices, and low-noise orthotic joint devices with intermittent normal force-transmitting contact associated with resistive or assistive forces provided by the devices, and methods of using the devices and components.

Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A is a radical selected from the group consisting of A-1 through A-11, L is —C(R12a)R12b—C(R13a)R13b—; or 1,2-phenylene G is a radical selected from the group consisting of and R1, R2, R12a, R12b, R13a, R13b and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

Abstract: Architecture that provides a secure environment in which data (e.g., code, instructions, files, images, etc.) can be opened and run by a client application. Once opened the data can be viewed (in a “protected view”) by the user without incurring risk to other client processing and systems. Accordingly, the architecture mitigates malicious attacks by enabling users to preview untrusted and potentially harmful data (e.g., files) in a low risk manner. Files opened in the protected view are isolated from accessing key resources on the client computer and provides the user a safer way to read files that can contain dangerous content. The protected view also provides a seamless user experience. The user is unaware that the client is operating on data in a different mode and allows for the reduction of security prompts.

Abstract: A method of managing identities for use in a mobile telecommunications device in a telecommunications network has the following features. The identity management process is triggered and one or more parameters of a currently available mobile telecommunications network detected. An identity database is searched—each record in the identity database comprises an identity and additional identity information for each identity. The additional identity information includes the one or more parameters. The identity management process involves selecting an identity when a first record comprising the one or more parameters detected is found in said searching and modifying an active identity of the mobile telecommunications device to be the selected identity when the active identity is not already the selected identity. This process can be carried out by a subscriber information module of a mobile telecommunications device.

Abstract: A method of managing identities for use in a mobile telecommunications device in a telecommunications network is described. First of all, an identity management process is triggered. After this, one or more parameters associated with the mobile telecommunications device is detected. The identity management process than has the following features. An identity management rule determined by the one or more parameters is detected. An identity database is then searched. Each record of the identity database comprises an identity and additional identity information for each identity, wherein the searching prioritises records according to the identity management rule. An identity is then selected when a record conforming to the identity management rule is found in said searching. The active identity of the mobile telecommunications device is then changed to be the selected identity when the active identity is not already the selected identity.

Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof: wherein R1, R2, R3, R2A, R3A, R4, R5, R6, Q1, Q2, Y1 and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Abstract: The present invention relates to a method for managing the automatic provision of a subscriber network identifier from a central network server to a subscribed communication device, the method comprising receiving notification at the central server relating to a change in the current location for the subscribed device, and determining from the notification whether a new subscriber network identifier is to be provisioned from the central server. The method further comprises selecting a subscriber network identifier on the basis of the current location, if the determining step has determined that a new subscriber network identifier is to be provisioned, and outputting the selected subscriber network identifier for transmission to the subscribed device. The present invention also relates to managing the automatic connection of a subscribed communication device to a network, where a preferred network and preferred subscriber network identifier may be used.

Abstract: Architecture that provides a secure environment in which data (e.g., code, instructions, files, images, etc.) can be opened and run by a client application. Once opened the data can be viewed (in a “protected view”) by the user without incurring risk to other client processing and systems. Accordingly, the architecture mitigates malicious attacks by enabling users to preview untrusted and potentially harmful data (e.g., files) in a low risk manner. Files opened in the protected view are isolated from accessing key resources on the client computer and provides the user a safer way to read files that can contain dangerous content. The protected view also provides a seamless user experience. The user is unaware that the client is operating on data in a different mode and allows for the reduction of security prompts.

Abstract: The present invention relates to a method for managing the automatic provision of a subscriber network identifier from a central network server to a subscribed communication device, the method comprising receiving notification at the central server relating to a change in the current location for the subscribed device, and determining from the notification whether a new subscriber network identifier is to be provisioned from the central server. The method further comprises selecting a subscriber network identifier on the basis of the current location, if the determining step has determined that a new subscriber network identifier is to be provisioned, and outputting the selected subscriber network identifier for transmission to the subscribed device. The present invention also relates to managing the automatic connection of a subscribed communication device to a network, where a preferred network and preferred subscriber network identifier may be used.

Abstract: A method of managing identities for use in a mobile telecommunications device in a telecommunications network is described. First of all, an identity management process is triggered. After this, one or more parameters associated with the mobile telecommunications device is detected. The identity management process than has the following features. An identity management rule determined by the one or more parameters is detected. An identity database is then searched. Each record of the identity database comprises an identity and additional identity information for each identity, wherein the searching prioritizes records according to the identity management rule. An identity is then selected when a record conforming to the identity management rule is found in said searching. The active identity of the mobile telecommunications device is then changed to be the selected identity when the active identity is not already the selected identity.

Abstract: A cosmetic composition includes water in an amount of from 20 to 70% by weight of the total composition; saturated fats in an amount of 6% to 15% by weight of the total composition; and an emulsifier. The cosmetic composition may be free from preservatives.

Abstract: A cosmetic composition includes a colloidal dispersion of a clay; water in an amount of 10 to 30% by weight of the total composition; and humectant in an amount of 25 to 60% by weight of the total composition. The cosmetic composition may be free from preservatives.

Abstract: Systems and methods for personalizing dialogues are disclosed. A dialog system can provide a user interface to allow a first user to specify a second user to participate in an automated dialog, a specific response option, and a maximum time period for responding. The dialog system can send a message to the second user with the specific response option. The dialog system can branch the dialog based on the occurrence of an event or combination of events occurring in conjunction the second user. In a first branch, the dialog system is configured to send a second communication to the second user using a second communications channel, the second communication containing the specific response option. In a second branch, the dialog system is further configured to execute a third instruction associated with the dialog.