Abstract: In one aspect, an improved ankle joint device provides two stages of dorsiflexion resistance biasing a first splint member (or other attachment member that follows the angular displacement of a wearer's lower leg or foot) against dorsiflexion movement within an active angular range of dorsiflexion, corresponding to second and third rocker phases of a wearer's gait; in addition to a phase of plantarflexion resistance biasing the first splint/attachment member against plantarflexion movement within an active angular range of plantarflexion, corresponding to a first rocker phase. In another aspect, an equilibrium or neutral angle between a wearer's foot and tibia at which the device applies no biasing forces is adjustable by adjusting the angle at which a second splint/attachment member is fixed relative to a joint body. Typically, the second splint member is secured to a wearer's lower leg, and the first splint member is secured to a wearer's foot.

Abstract: A method and cell line for producing polyketides in yeast. The method applies, and the cell line includes, a yeast cell transformed with a polyketide synthase coding sequence. The polyketide synthase enzyme catalyzes synthesis of olivetol or methyl-olivetol, and may include Dictyostelium discoideum polyketide synthase (“DiPKS”). Wild type DiPKS produces methyl-olivetol only. DiPKS may be modified to produce olivetol only or a mixture of both olivetol and methyl-olivetol. The yeast cell may be modified to include a phosphopantethienyl transferase for increased activity of DiPKS. The yeast cell may be modified to mitigate mitochondrial acetaldehyde catabolism for increasing malonyl-CoA available for synthesizing olivetol or methyl-olivetol.

Abstract: A system for tracking position of objects in an industrial environment includes an interrogator, a transponder, and a processor. The interrogator transmits a signal and provides a first reference signal corresponding to the transmitted signal. The transponder provides a response signal. The interrogator receives the response signal and provides a second reference signal corresponding to the response signal. The processor determines a location of either the interrogator or the transponder, relative to the other, based on the two reference signals.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: A scanning apparatus for measuring the attenuation of radiation passing from a radiation source along a radiation path to a radiation detector includes a source of radiation; at least one radiation detector capable of detecting radiation emitted by the source a data processor associated with the at least one radiation detector for calculating a property of material present in a linear radiation path between the source and the at least one detector; and a spacer arranged between the source and the at least one detector. The spacer defines a space which is capable of excluding water and having an average density which is less than 1 gcm?3. The provision of a spacer in the radiation path enables more radiation to be passed along the radiation path because water can be replaced with a material which is less attenuating to radiation.

Abstract: A spreader includes a frame having wheels mounted on an axle. A gear assembly on the axle is coupled with a shaft. A hopper is mounted on the frame and holds particulate that empties through an opening within the bottom wall. An impeller is mounted on the shaft and receives the particulate emptied from the hopper. A controlled-release assembly is mounted about the shaft and includes a drive housing secured to the hopper. The drive housing has a funnel opening to dispense the particulate therethrough. A transfer wheel within the drive housing is rotatably coupled to the shaft. When the shaft is rotating, the transfer wheel rotates whereby the particulate is delivered to the funnel. When the shaft is stationary, the transfer wheel is stationary whereby particulate is not delivered to the funnel.

Abstract: A method for determining the availability of at least one target user for a specific type of communication is described.

Abstract: Disclosed are compounds of Formula 1, including all N-oxides, stereoisomers, and salts thereof, wherein Q1, Q2, R1, R2, Y, J and R7 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Abstract: A system for tracking position of objects in an industrial environment includes an interrogator, a transponder, and a processor. The interrogator transmits a signal and provides a first reference signal corresponding to the transmitted signal. The transponder provides a response signal. The interrogator receives the response signal and provides a second reference signal corresponding to the response signal. The processor determines a location of either the interrogator or the transponder, relative to the other, based on the two reference signals.

Abstract: A compound of formula (I): being 4-(3-Fluoro-3-(2-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.

Abstract: Disclosed is an artists' watercolor paint composition comprising, at least one pigment; one or more humectants; a binder selected from one or more alkali soluble polymers; and a pH stabilizer in an amount effective to adjust the mixture to an alkali pH so that the watercolor paint composition is water soluble. Also disclosed are uses of the paint composition in providing watercolor paintings.

Abstract: A system and method for optimizing power consumption of energy harvesting nodes in a wireless sensor network. In one embodiment, a system includes a network coordinator. The network coordinator includes a wireless transceiver and a controller. The wireless transceiver is configured to provide access to the wireless sensor network. The controller is configured to determine whether a wireless device that is wirelessly communicating with the network coordinator is powered via energy harvesting. The controller is also configured to schedule, based on a determination that the wireless device is powered via energy harvesting, the wireless device to communicate via the wireless sensor network using a priority timeslot of a superframe of the wireless sensor network. The priority timeslot is a timeslot occurring in an initial portion of the superframe.

Abstract: Techniques for dynamically building documentation based on installed services are described herein. In an embodiment, a plurality of different electronic documents are stored in a data repository. A server computer system identifies one or more service software components of an application program that have been installed as part of a particular application instance. The server computer identifies a subset of one or more particular documents from the plurality of documents stored in the data repository that correspond to the identified one or more services. Using the subset of one or more particular documents, the server generates a particular customized document which is then stored in association with the particular application instance.

Abstract: A compound of formula (I): being 4-(3-Fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.

Abstract: A cosmetic composition includes water in an amount of from 20% to 70% by weight of the total composition; saturated fats in an amount of 6% to 15% by weight of the total composition; and an emulsifier. The cosmetic composition may be free from preservatives.

Abstract: A method of managing identities for use in a mobile telecommunications device in a telecommunications network has the following features. The identity management process is triggered and one or more parameters of a currently available mobile telecommunications network detected. An identity database is searched—each record in the identity database comprises an identity and additional identity information for each identity. The additional identity information includes the one or more parameters. The identity management process involves selecting an identity when a first record comprising the one or more parameters detected is found in said searching and modifying an active identity of the mobile telecommunications device to be the selected identity when the active identity is not already the selected identity. This process can be carried out by a subscriber information module of a mobile telecommunications device.

Abstract: A constructional toy comprising a plurality of elements which can be assembled together to form a variety of three dimensional structures. The elements include a triangular prism shaped brick element comprising a plurality of walls. The walls define a male mating side having a male engagement feature which extends from the brick. The walls also define a female mating side which defines a cavity configured for receiving an engagement feature of the same configuration as provided on the male mating side.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: Systems and methods for personalizing dialogs are disclosed. A dialog system can provide a user interface to allow a first user to specify a second user to participate in an automated dialog, a specific response option, and a maximum time period for responding. The dialog system can send a message to the second user with the specific response option. The dialog system can branch the dialog based on the occurrence of an event or combination of events occurring in conjunction the second user. In a first branch, the dialog system is configured to send a second communication to the second user using a second communications channel, the second communication containing the specific response option. In a second branch, the dialog system is further configured to execute a third instruction associated with the dialog.