Abstract: Kinematic mounts are used frequently to hold objects such as mirrors, lenses, and other optical equipment. To adjust kinematic mounts, adjustment mechanisms are often required. Adjustment mechanisms can be used to make fine adjustments in applications where precision is required (e.g., laser system prototyping). Kinematic mounts that include never-before implemented form factors and structural elements require new adjustment solutions, and those solutions are described in this application. Adjustment mechanisms described in this application include a main body, a control frame, and control screws to adjust the orientation of the control frame. The control frame is coupled with a kinematic mount's housing, which rotates about a center of curvature of a bottom surface of the housing.

Abstract: A system and method for reducing energy consumption in a wireless network. In one embodiment, a system includes a network coordinator configured to manage access to a wireless network. The network coordinator includes a controller. The controller is configured to define a channel hopping list that specifies on which channel a beacon signal is transmitted in each slot frame of the wireless network. The controller is also configured to set a number of time slots in each slot frame based on a length of the channel hopping list. The controller is further configured to transmit a first beacon signal in each slot frame on a channel specified by the channel hopping list. The number of slots in each slot frame causes the first beacon signal to be transmitted on a same channel in each slot frame.

Abstract: Kinematic mounts disclosed in this application are made from three main components: a housing, a footing, and a tightening mechanism. The tightening mechanism includes three parts: a top portion, a bottom portion, and a locking interface mechanism. When the top portion, which includes a hollow tip with interior threading, is screwed down onto the bottom portion, which includes a threaded tip, the locking interface component is pressed against at least one interior surface of the housing that causes the housing to be pressed against the footing. This action holds the housing in place relative to the footing while simultaneously preventing unwanted movement of the housing during tightening.

Abstract: Kinematic mounts are used frequently to hold objects such as mirrors, lenses, and other optical equipment. To adjust kinematic mounts, adjustment mechanisms are often required. Adjustment mechanisms can be used to make fine adjustments in applications where precision is required (e.g., laser system prototyping). Kinematic mounts that include never-before implemented form factors and structural elements require new adjustment solutions. This application describes systems that include both novel kinematic mounts as well as new adjustment mechanisms developed to reorient the new kinematic mounts. Adjustment mechanisms described in this application include a main body, a control frame, and control screws to adjust the orientation of the control frame. The control frame is coupled with a kinematic mount's housing, which rotates about a center of curvature of a bottom surface of the housing.

Abstract: A system and method for optimizing power consumption of energy harvesting nodes in a wireless sensor network. In one embodiment, a system includes a network coordinator. The network coordinator includes a wireless transceiver and a controller. The wireless transceiver is configured to provide access to the wireless sensor network. The controller is configured to determine whether a wireless device that is wirelessly communicating with the network coordinator is powered via energy harvesting. The controller is also configured to schedule, based on a determination that the wireless device is powered via energy harvesting, the wireless device to communicate via the wireless sensor network using a priority timeslot of a superframe of the wireless sensor network. The priority timeslot is a timeslot occurring in an initial portion of the superframe.

Abstract: A method and cell line for producing polyketides in yeast. The method applies, and the cell line includes, a yeast cell transformed with a polyketide synthase coding sequence. The polyketide synthase enzyme catalyzes synthesis of olivetol or methyl-olivetol, and may include Dictyostelium discoideum polyketide synthase (“DiPKS”). Wild type DiPKS produces methyl-olivetol only. DiPKS may be modified to produce olivetol only or a mixture of both olivetol and methyl-olivetol. The yeast cell may be modified to include a phosphopantethienyl transferase for increased activity of DiPKS. The yeast cell may be modified to mitigate mitochondrial acetaldehyde catabolism for increasing malonyl-CoA available for synthesizing olivetol or methyl-olivetol.

Abstract: Techniques for visualizing dependencies in a data analytics system are described. In an embodiment, a visualization system may receive datasets and dataset dependency information for the datasets. The visualization system may receive a first type of analysis objects from a first analysis object system and dataset dependency information from an analysis object dependency service. The visualization system may receive a second type of analysis objects from a second analysis object system. The second type of analysis object may include a JSON representation of a set of operations that are applied during analysis such as a set of programming instructions. The visualization system may traverse and analyze the JSON representation to determine, for a given analysis object, one or more parent dependencies. The visualization system can then generate a graph of the datasets and analysis objects.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: According to aspects of the invention there is provided a remote unit comprising a processor and one or more terminal interfaces, the processor being connected to the one or more terminal interfaces, the terminal interfaces configured for coupling with a set of terminals, wherein the processor is configured to perform quality of service network testing using one or more of the set of terminals over one or more communication networks.

Abstract: Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-?4?7 integrin antibody such as vedolizumab. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-?4?7 integrin antibody.

Abstract: A system and method for reducing energy consumption in a wireless network. In one embodiment, a system includes a network coordinator configured to manage access to a wireless network. The network coordinator includes a controller. The controller is configured to define a channel hopping list that specifies on which channel a beacon signal is transmitted in each slot frame of the wireless network. The controller is also configured to set a number of time slots in each slot frame based on a length of the channel hopping list. The controller is further configured to transmit a first beacon signal in each slot frame on a channel specified by the channel hopping list. The number of slots in each slot frame causes the first beacon signal to be transmitted on a same channel in each slot frame.

Abstract: This disclosure relates, in part, to compounds of Formula 1 (including all stereoisomers), N-oxides of such compounds, and salts of such compounds and N-oxides: wherein L, Y1, R1, J, Q1, R7, Y2, R9 and Q2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Abstract: Described herein are techniques for determining motion characteristics (e.g., position, velocity, acceleration, etc.) of one or more trains traveling along a train track, such that train control systems may have the information needed to safely operate the trains at higher speeds and with shorter separation between trains. In accordance with various embodiments, systems and methods described herein may be configured to determine a position, velocity, and/or acceleration of a train traveling along a train track. In some embodiments, the motion characteristics may be determined one or more radio frequency antennas onboard the train, such as in communication with one or more anchor nodes positioned adjacent the train track. Alternatively or additionally, in some embodiments motion characteristics may be determined using one or more one or more inertial measurement units (IMUs) onboard the train.

Abstract: Described herein are techniques for determining motion characteristics (e.g., position, velocity, acceleration, etc.) of one or more trains traveling along a train track, such that train control systems may have the information needed to safely operate the trains at higher speeds and with shorter separation between trains. In accordance with various embodiments, systems and methods described herein may be configured to determine a position, velocity, and/or acceleration of a train traveling along a train track. In some embodiments, the motion characteristics may be determined one or more radio frequency antennas onboard the train, such as in communication with one or more anchor nodes positioned adjacent the train track. Alternatively or additionally, in some embodiments motion characteristics may be determined using one or more one or more inertial measurement units (IMUs) onboard the train.

Abstract: A method and cell line for producing polyketides in yeast. The method applies, and the cell line includes, a yeast cell transformed with a polyketide synthase coding sequence. The polyketide synthase enzyme catalyzes synthesis of olivetol or methyl-olivetol, and may include Dictyostelium discoideum polyketide synthase (“DiPKS”). Wild type DiPKS produces methyl-olivetol only. DiPKS may be modified to produce olivetol only or a mixture of both olivetol and methyl-olivetol. The yeast cell may be modified to include a phosphopantethienyl transferase for increased activity of DiPKS. The yeast cell may be modified to mitigate mitochondrial acetaldehyde catabolism for increasing malonyl-CoA available for synthesizing olivetol or methyl-olivetol.

Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

Abstract: Electronic note management via a connected entity graph.

Abstract: A system, comprising: a plurality of wayside devices positioned along a train track, the plurality of wayside devices having known positions, each of the plurality of wayside devices comprising at least one first radio-frequency (RF) antenna; a work zone device positioned along the train track, the work zone device comprising at least one second RF antenna configured to transmit RF signals to and/or receive RF signals from the plurality of wayside devices; and at least one processor configured to determine a position of the work zone device using the known positions and using RF signals transmitted between the work zone device and the plurality of wayside devices.

Abstract: A system, comprising: a plurality of wayside devices positioned along a train track, the plurality of wayside devices having known positions, each of the plurality of wayside devices comprising at least one first radio-frequency (RF) antenna; a work zone device positioned along the train track, the work zone device comprising at least one second RF antenna configured to transmit RF signals to and/or receive RF signals from the plurality of wayside devices; and at least one processor configured to determine a position of the work zone device using the known positions and using RF signals transmitted between the work zone device and the plurality of wayside devices.

Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N oxides, and salts thereof, wherein R1, R4, R5, R6, J, Q1, Q2, A, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.