Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5?)ppp(5?)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for harmonizing diffusion tensor images. One of the methods includes obtaining a diffusion tensor image; determining a set of RISH features for the diffusion tensor image; processing a model input generated from the set of RISH features using a machine learning model to generate a model output identifying an image transformation from a set of image transformations, wherein each image transformation in the set of image transformations corresponds to a respective different first MRI scanner and represents a transformation that, when applied to first diffusion tensor images captured by the first MRI scanner, harmonizes the first diffusion tensor images with second diffusion tensor images captured by a reference MRI scanner; and processing the diffusion tensor image using the identified image transformation to generate a harmonized diffusion tensor image.

Abstract: According to one aspect, a vehicle includes hardware systems configured to support the autonomous or semi-autonomous operation of the vehicle. Hardware systems may include a main compute, a brain stem computer (BSC), and an aggregator/compute arrangement or redundant autonomy compute. Such hardware systems may cooperate to allow the vehicle to operate autonomously, and typically provide capabilities, e.g., redundant and/or backup capabilities, configured to enable the vehicle to continue to operate in the event that a primary system is not functioning as expected. The aggregator/compute arrangement may further be comprised of two substantially identical modules or computing assemblies, each configured to process sensor data and perform backup autonomy functionalities and/or teleoperations functionalities.

Abstract: The present invention relates to herbicidal combinations and their use in controlling plants or inhibiting plant growth. In particular, herbicidal combinations comprising at least one pyridazine derivative of Formula (I) as defined herein, in combination with at least one further herbicide that is a compound of Formula (II) as defined herein.

Abstract: The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient using a centrality ranking of the brain of the patient. One of the methods includes obtaining brain data of a patient, wherein the brain data comprises, for each of a plurality of pairs of parcellations formed from a set of parcellations where each pair comprises a first parcellation and a second parcellation, data characterizing a number of tracts connecting the first parcellation and the second parcellation; determining a network graph from the brain data; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; determining a centrality ranking of the plurality of nodes of the network graph according to the respective measures of centrality; generating a mental health prediction for the patient using the determined centrality ranking.

Abstract: Accessed from memory are i) a first brain image, ii) a second brain image, iii) a difference map, and iv) a connectivity element. A GUI may include: concurrently displaying each of these elements. User input to the GUI is received. A location of the user input is determined. The operations also include responsive to determining that the location of the user input is within the display of the first brain image, modifications are made to the display of the i) second brain image, ii) the difference map, and iii) the connectivity element to highlight elements of the display that correspond to an element of the first brain image that corresponds to the location of the user input.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for displaying hubs in brain data. One of the methods includes receiving hub data, the hub data comprising anatomical data and connectivity data of at least part of a brain, the connectivity data comprising a first plurality of nodes and a second plurality of edges, each edge of the second plurality of edges connecting a pair of nodes among the first plurality of nodes; forwarding the hub data to a user computer for display; receiving a first user indication requesting a display of unexpected hub data; determining, in response to the first user indication, unexpected hub data comprising nodes that have connectivity outside of a specified threshold; and forwarding the unexpected hub data to the user computer for display.

Abstract: Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Abstract: The present invention relates to novel herbicidal combinations and their use in controlling plants or inhibiting plant growth. In particular, herbicidal combinations of the invention comprise at least one pyridazine derivative of Formula (I), in combination with at least one further herbicide that is a non-selective herbicide, a herbicide that acts through the inhibition of protoporphoryinogen oxidase, or a herbicide that inhibits photosystem II in photosynthesis.

Abstract: The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient. One of the methods includes obtaining brain data captured by one or more sensors characterizing a brain of a patient; determining a network graph from the brain data, wherein: a node of the network graph corresponds to a parcellation in the brain of the patient, and a subset of nodes of the network graph corresponds to a particular functional area of the brain; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; generating, for the particular functional area of the brain and using the generated measures of centrality, a health score representing a measure of health of the functional area of the brain; generating a mental health prediction for the patient using the health score.

Abstract: The techniques of this disclosure relate to a system for adjusting a focus of an image. A system includes a phased metalens configured to adjust a focus of an image detected by an imaging substrate of an image sensor to compensate for warpage of the imaging substrate. The phased metalens can achieve a near-diffraction-limited focusing over incoming light wavelengths using precisely defined nanoscale subwavelength resolution structures.

Abstract: The present invention relates to herbicidally active cinnolinium derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants.

Abstract: One or more parking sensors are configured to determine a distance between a vehicle and an obstacle. A controller is configured to determine a threshold parking distance based on an operating mode of the vehicle; compare the determined distance with the threshold parking distance; and provide an indication to a user of the vehicle based on the determined distance being less than or equal to the threshold parking distance.

Abstract: The present invention provides engineered transglutamirase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.

Abstract: The present invention relates to herbicidally active pyridazine derivatives of Formula (I) as defined herein, as well as to herbicidal compositions comprising such derivatives, and the use of such compounds and compositions for controlling undesirable plant growth: in particular the use for controlling weeds, in crops of useful plants.

Abstract: The present invention relates herbicidal combinations and their use in controlling plants or inhibiting plant growth. In particular, herbicidal combinations of the invention comprise at least one pyridazine derivative of Formula (I) as defined herein, in combination with at least one further herbicide that is a pyrrolidinone derivatives of the Formula (II) as defined herein.

Abstract: Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides: wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound, N-oxide, salt or composition.

Abstract: An apparatus includes a plurality of surge protection devices (e.g., multiple metal oxide varistors connected in parallel) configured to be coupled to a power system, a plurality of mechanical actuators associated with respective ones of the surge protection devices and configured to indicate status of the associated surge protection devices, and a detector circuit configured to sense actuation of the actuators and responsively determine a protection status of the plurality of surge protection devices. The detector circuit may include a plurality of switches configured to be actuated by respective ones of the actuators. The detector circuit may further include a processor coupled to the plurality of switches and configured to determine states of switches and to determine the protection status based on the determined status of the switches. The processor may be configured to interpret the status of the switches based on a stored identifier.