Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5?)ppp(5?)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5?)ppp(5?)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

Abstract: A method and system of screening persons boarding an aircraft to detect a febrile condition of each person are disclosed. According to one aspect, a method includes: detecting an open condition of a door of the aircraft; when the door is in an open condition, detecting a presence of a person entering through the door; thermally and optically imaging the person; determining a febrile condition of the person; and when the person is in a febrile condition, alerting aircraft employees.

Abstract: The following provides an exemplary method. An image is generated. Scan data generated by the sensing of a subject brain is received and a sequence of volumetric-images are accessed. For at least some of the voxels in at least some of the volumetric images, a change value is determined for the voxel by comparing the current-intensity value of the voxel to the adjacent-intensity value of the comparison voxel. For at least some of the plurality volumetric images, a first-aggregate is determined using at least a mean value of change values of the volumetric image and a second-aggregate is determined using at least a median value of change values of the volumetric image. At least one, but not all, of the volumetric images is determined as invalid as a result of the aggregates.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining anomalous brain data. One of the methods includes obtaining brain data characterizing brain activity of a patient; for each of a plurality of pairs of parcellations comprising a first parcellation and a second parcellation, processing the brain data to generate a correlation between the brain activity of the first and second parcellations; obtaining second connectivity data that characterizes, for each of the plurality of pairs of parcellations, a normal range of correlations between the brain activity of the first and second parcellations; identifying one or more of the plurality of pairs of parcellations for which the correlation between brain activity of the first and second parcellations is outside of the corresponding normal range of correlations; and providing data characterizing the one or more identified pairs of parcellations for display to a user on a graphical interface.

Abstract: A method (500) for protection of a vehicle (100), the method comprising: receiving information from a sensor (502); comparing the information with known signatures indicative of a likely attack (504); determining whether a known signature indicative of a likely attack is present (506); and if a known signature indicative of a likely attack is present, placing at least one system of the vehicle into a heightened state of alert (508).

Abstract: Use of the compounds of the formula (I) wherein the substituents are as defined herein as herbicides. Compounds of formula (I) are also claimed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for identifying one or more invalid images characterizing the brain of a patient. One of the methods includes obtaining a data object comprising one or more images characterizing a brain of a patient; processing the data object to determine one or more particular images that are invalid; and providing, for display to a user on a graphical interface, data characterizing i) each particular image and ii) a respective reason that each particular image is invalid selected from a set of possible reasons that an image may be invalid.

Abstract: A constant resistance exercise machine for sprint training or adaptation into exercise equipment having cyclical movements, preferably over a distance. The constant resistance exercise machine includes an exercise cable storage and feed reel, a constant tension spring motor, a resistance generating assembly, a flywheel, and an exercise cable. The constant tension spring motor is in operational communication with the exercise cable reel. The flywheel obtains a rotational resistance from the resistance generating assembly. The flywheel is in unidirectional rotational communication with the exercise cable reel via a one-way clutch bearing. The exercise cable is coiled about the exercise cable reel. The exercise cable is of a length that enables complete extraction of the cable from the exercise cable storage and feed reel and wherein the constant tension spring motor is arranged to retract a partially or completely extracted cable back onto the exercise cable reel.

Abstract: Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides: wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound, N-oxide, salt or composition.

Abstract: Bus mounted surge protection devices are provided that are configured to be positioned in a panelboard alongside one or more similarly sized circuit breaker devices. The bus mounted surge protection device is configured to be received by a same provisional bus as the one or more circuit breaker devices and the bus mounted surge protection device is configured to protect all of the one or more circuit breaker devices in the panelboard.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing brain data using autoencoder neural networks. One of the methods includes obtaining brain data captured by one or more sensors characterizing brain activity of a patient; processing the brain data to generate modified brain data that characterizes a predicted local effect of a future treatment on the brain of the patient; processing the modified brain data using an autoencoder neural network to generate reconstructed brain data; and determining, using the reconstructed brain data, a predicted global effect of the future treatment on the brain of the patient.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for predicted brain data of a patient. One of the methods includes receiving montage configuration data for a specified montage; receiving raw EEG data captured using the specified montage from a brain of a particular subject; generating, using the montage configuration data and the raw EEG data, EEG connectivity data for the specified montage; using a generative neural network to map the EEG connectivity data to predicted fMRI connectivity data, the generative neural network having been trained using training EEG-fMRI connectivity data pairs, each pair comprising EEG connectivity data of a subject and fMRI connectivity data of the same subject; and taking an action based on the predicted fMRI connectivity data.

Abstract: A pre-event connectome of a subject brain is accessed, the pre-event connectome defining i) first functional nodes in the subject brain and ii) first edges that represent connections between the first functional nodes before the subject has undergone an event. A post-event connectome of the subject brain is accessed, the post-event connectome defining i) second functional nodes in the subject brain and ii) second edges that represent connections between the second functional nodes after the subject has undergone the event. A connectome-difference map data is generated that records the difference between the pre-event connectome and the post-event connectome. An action is taken based on the connectome-difference map data.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing aphasia assessment. One of the methods includes receiving a recording, generating a text transcript of the recording, and generating speech quantifying and comprehension scores which can be used to determine an aphasia classification. Another method includes performing an aphasia assessment on a brain image to obtain an aphasia classification.

Abstract: This disclosure covers computer-implemented methods, non-transitory computer readable media, and systems that improve efficiency, accuracy, and flexibility in servicing provider vehicles associated with a transportation matching system. For example, the disclosed systems can match transportation provider vehicles to vehicle services at one or more multi-track vehicle service centers, guide provider vehicles through various tracks and services, and generate user interfaces for accurately and efficiently notifying provider devices and technician devices as vehicles progress through the multi-track vehicle service centers.

Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The present invention provides engineered branched chain ketoacid decarboxylase (KdcA) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered branched chain ketoacid decarboxylase (KdcA) polypeptides. In some embodiments, the engineered KdcA polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis and increased tolerance to storage at elevated temperatures. The present invention also provides methods for the use of the compositions comprising the engineered KdcA polypeptides for therapeutic and industrial purposes.

Abstract: A method for a vehicle is provided. The method comprises: determining a weight and position of an item of cargo being transported by the vehicle; transmitting information comprising the weight and position to a cargo management system remote from the vehicle; receiving a weight distribution instruction from the cargo management system; and communicating the weight distribution instruction to an occupant of the vehicle.