Abstract: There is described a two-terminal multi-level memristor element synthesised from binary memristors, which is configured to implement a variable resistance based on unary or binary code words. There is further described a circuit such as a synapse circuit implemented using a multi-level memristor element.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting a structure of a protein that comprises a plurality of amino acid chains.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: There is described a two-terminal multi-level memristor element synthesised from binary memristors, which is configured to implement a variable resistance based on unary or binary code words. There is further described a circuit such as a synapse circuit implemented using a multi-level memristor element.

Abstract: This application relates to computing circuitry (200, 500, 600) for analogue computing. A plurality of current generators (201) are each configured to generate a defined current (ID1, ID2, . . . IDj) based on a respective input data value (D1, D2, . . . Dj). A memory array (202), having at least one set (204) of programmable-resistance memory cells (203), is arranged to receive the defined currents from each of the current generators at a respective signal line (206). Each set (204) of programmable-resistance memory cells (203) includes a memory cell associated with each signal line that, in use, can be connected between the relevant signal line and a reference voltage so as to generate a voltage on the signal line. An adder module (207) is coupled to each of the signal lines to generate a voltage at an output node (210) based on the sum of the voltages on each of the signal lines.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting a structure of a protein comprising one or more chains. In one aspect, a method comprises: obtaining an initial multiple sequence alignment (MSA) representation; obtaining a respective initial pair embedding for each pair of amino acids in the protein; processing an input comprising the initial MSA representation and the initial pair embeddings using an embedding neural network to generate an output that comprises a final MSA representation and a respective final pair embedding for each pair of amino acids in the protein; and determining a predicted structure of the protein using the final MSA representation, the final pair embeddings, or both.

Abstract: This application relates to methods and apparatus for computing, especially to circuitry for performing computing, at least partly, in the analogue domain. The circuitry (200) comprises a plurality of memory cells (201), each memory cell having first and second paths between an electrode (202) for receiving an input current and respective positive and negative electrodes (203) for outputting a differential-current output. Memristors (101) are located in the first and second paths. The memory cells are configured into sets (205) of memory cells, the memory cells of each said set being connected so as to provide a differential current set output that corresponds to a combination of the cell outputs of all of the memory cells of that set. For each set, at least some of the memory cells of that set are configured to receive a different input current to other memory cells of that set.

Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

Abstract: There is described a two-terminal multi-level memristor element synthesised from binary memristors, which is configured to implement a variable resistance based on unary or binary code words. There is further described a circuit such as a synapse circuit implemented using a multi-level memristor element.

Abstract: A beverage brewing device includes a brew chamber and a plunger. The brew chamber includes at least one water permeable portion and an openable base. The plunger includes a plunger face corresponding to an internal shape of the brew chamber. The openable base is openable by action of the plunger.

Abstract: The invention relates to a microarray structure that may include a substrate material layer, a continuous three-dimensional (3D) surface layer on the substrate material layer that is capable of functionalisation for use as an array, and an inert material. The structure may include accurately defined and functionalisable isolated areas which are millimeter to nanometer in size. The functionalisable areas may be part of the continuous 3D surface layer and may be isolated by the inert material but interconnected within the structure by the continuous 3D surface layer.

Abstract: This application relates to methods and apparatus for temperature monitoring for integrated circuits, and in particular to temperature monitoring using a locked-loop circuits, e.g. FLLs, PLLs or DLLs. According to embodiments a locked-loop circuit includes a controlled signal timing module, wherein the timing properties of an output signal (SOUT, SFB) are dependent on a value of a control signal and on temperature. A controller compares a feedback signal (SFB) output from the timing module to a reference signal (SREF) and generates a control signal (SC) to maintain a desired timing relationship. A temperature monitor monitors temperature based on the value of the control signal. For FLLs and PLLs the signal timing module may be a controlled oscillator.

Abstract: A sensor for the detection of an analyte in a fluid includes an electrode having a detection surface, a polydopamine layer adhered to the electrode detection surface; and optionally a receptor chemically functionalized to the polydopamine of the detection surface of the electrode. The receptor selectively binds to the analyte of interest and the analyte once bound is detectable by measuring the change of capacitance of the electrode.

Abstract: A high pressure delivery system for delivering a medicament, comprising a first chamber for storing a supply of the medicament, a gear pump assembly in fluid communication with the first chamber, said gear pump assembly having a dose inlet and a dose discharge, said dose inlet having a larger diameter than said dose discharge to provide a high pressure discharge, and a fluid connection path in fluid communication with the gear pump assembly for delivering the medicament to a high pressure area.

Abstract: A disposable pen needle, comprising a hub having a needle situated thereon having a patient end and a non-patient end, a removable patient end cap attached at the distal end of the hub, a removable non-patient end cap attached at the proximal end of the hub, wherein greater force is required to detach the patient end cap than is required to detach the non-patient end cap.

Abstract: A pen needle, comprising a reusable adapter configured for attachment to a distal end of a medication pen, the adapter having a proximal needle for accessing the interior of the pen injector and a fitting on the distal side for mating with a patient end needle assembly, and a disposable patient-end needle assembly having a base configured for mating with the fitting on the distal side of the adapter and a patient-end needle extending from a distal end of the base.

Abstract: A handheld vacuum cleaner includes a pistol grip which is positioned generally transverse to a longitudinal axis of the vacuum cleaner that runs from a front end to a rear end thereof. It also includes an air inlet positioned forward of the pistol grip, and a vacuum motor configured to draw dirty air into a dirt separator of the vacuum cleaner through the air inlet and exhaust clean air from the vacuum cleaner through an air outlet. The handheld vacuum cleaner further includes an electronic visual display which faces generally rearwards. The handheld vacuum cleaner may be part of a stick vacuum cleaner.