Abstract: The invention relates to a microarray structure that may include a substrate material layer, a continuous three-dimensional (3D) surface layer on the substrate material layer that is capable of functionalisation for use as an array, and an inert material. The structure may include accurately defined and functionalisable isolated areas which are millimeter to nanometer in size. The functionalisable areas may be part of the continuous 3D surface layer and may be isolated by the inert material but interconnected within the structure by the continuous 3D surface layer.

Abstract: A patient interface is configured to deliver a flow of positive pressure respiratory gas to an entrance of a patients airways. The patient interface includes an elastomeric support wall forming at least part of a plenum chamber configured to receive the flow of positive pressure respiratory gas. The patient interface also includes an elastomeric support flange positioned at an end of the elastomeric support wall and extending radially inward from the support wall. The support flange has a flap portion at a central superior region of the support flange that extends further in the radially inward direction than the rest of the support flange. In addition, a foam cushion is mounted on the support flange. The foam cushion is configured to form a seal with the patients face and includes an attachment surface that is in contact with an outer surface of the support flange.

Abstract: This application relates to methods and apparatus for temperature monitoring for integrated circuits, and in particular to temperature monitoring using a locked-loop circuits, e.g. FLLs, PLLs or DLLs. According to embodiments a locked-loop circuit includes a controlled signal timing module, wherein the timing properties of an output signal (SOUT, SFB) are dependent on a value of a control signal and on temperature. A controller compares a feedback signal (SFB) output from the timing module to a reference signal (SREF) and generates a control signal (SC) to maintain a desired timing relationship. A temperature monitor monitors temperature based on the value of the control signal. For FLLs and PLLs the signal timing module may be a controlled oscillator.

Abstract: A patient interface comprises a plenum chamber and a seal-forming structure. The seal-forming structure comprises a support structure arranged to support a sealing portion that is adapted to sealing engage the patient's face in use. The seal-forming structure may also include a seal biasing portion configured to inflate under pressurization within the cavity in the cushion assembly in use to extend the reach of the sealing portion and decouple the sealing portion from external forces.

Abstract: A patient interface including a positioning and stabilizing structure that is configured to maintain a first seal-forming structure and a second seal-forming structure in a therapeutically effective position. The positioning and stabilizing structure comprises a frame coupled to the plenum chamber. The frame includes a central portion coupled to the plenum chamber outside of the cavity. The frame also includes a pair of arms that extend away from the central portion in a posterior direction past the second seal-forming structure. The pair of arms are more flexible than the central portion. The positioning and stabilizing structure also includes headgear straps coupled to the frame, which configured to provide a tensile force to the first seal-forming structure and to the second seal-forming structure into the patient's face via the frame.

Abstract: A sensor for the detection of an analyte in a fluid includes an electrode having a detection surface, a polydopamine layer adhered to the electrode detection surface; and optionally a receptor chemically functionalized to the polydopamine of the detection surface of the electrode. The receptor selectively binds to the analyte of interest and the analyte once bound is detectable by measuring the change of capacitance of the electrode.

Abstract: A high pressure delivery system for delivering a medicament, comprising a first chamber for storing a supply of the medicament, a gear pump assembly in fluid communication with the first chamber, said gear pump assembly having a dose inlet and a dose discharge, said dose inlet having a larger diameter than said dose discharge to provide a high pressure discharge, and a fluid connection path in fluid communication with the gear pump assembly for delivering the medicament to a high pressure area.

Abstract: A disposable pen needle, comprising a hub having a needle situated thereon having a patient end and a non-patient end, a removable patient end cap attached at the distal end of the hub, a removable non-patient end cap attached at the proximal end of the hub, wherein greater force is required to detach the patient end cap than is required to detach the non-patient end cap.

Abstract: A patient interface may include a plenum chamber and a positioning and stabilising structure. The plenum chamber may include a seal-forming structure and a fascia portion. At least a medial portion of the fascia portion is flexible. In embodiments, the patient interface may include a rigidiser to control flexing of the fascia portion.

Abstract: A patient interface includes a frame assembly including connectors operatively attachable to headgear, a cushion assembly provided to the frame assembly and including a seal-forming structure structured to form a seal with the patient's nose and/or mouth, and an air delivery connector provided to the frame assembly and operatively connected to an air delivery tube for supplying the air at positive pressure along an air flow path. The cushion assembly is structured to releasably connect to the frame assembly independently of the air delivery connector. The air delivery connector is structured to releasably connect to the frame assembly independently of the cushion assembly.

Abstract: A patient interface comprises a plenum chamber and a seal-forming structure. The seal-forming structure comprises a support structure arranged to support a sealing portion that is adapted to sealing engage the patient's face in use. The seal-forming structure may also include a seal biasing portion configured to inflate under pressurization within the cavity in the cushion assembly in use to extend the reach of the sealing portion and decouple the sealing portion from external forces.

Abstract: A patient interface includes a frame assembly (16100) including connectors operatively attachable to headgear, a cushion assembly (16175) including a shell (161800) and a seal-forming structure (16200) structured to form a seal with the patient's nose and/or mouth, and an air delivery connector (16600). The cushion assembly and air delivery connector are structured to releasably connect to the frame assembly independently of each other. A static face seal and separate static diametric seal between the shell (161800) and frame (16100). A dynamic face seal and separate dynamic diametric seal between the air delivery connector (16600) and frame (16100). Separate claims (FIG. 6) to a frame assembly (16100) with upper headgear connector arms (16134) including at least one slot (6146) (claim 17) or flexible portions (claim 22) to form hinges structured and arranged to conform to varying facial profiles.

Abstract: A pen needle, comprising a reusable adapter configured for attachment to a distal end of a medication pen, the adapter having a proximal needle for accessing the interior of the pen injector and a fitting on the distal side for mating with a patient end needle assembly, and a disposable patient-end needle assembly having a base configured for mating with the fitting on the distal side of the adapter and a patient-end needle extending from a distal end of the base.

Abstract: A method of planning a coverage path to cover an area. The method includes a computing arrangement iteratively receiving, generating and displaying. The computing arrangement is configured to receive a range acceptable user-inputs. The receiving includes receiving user-input within the range of acceptable user-inputs. The generating includes generating a feasible coverage path based on the user-input. The displaying includes displaying at least some detail of the feasible coverage path.

Abstract: A handheld vacuum cleaner includes a pistol grip which is positioned generally transverse to a longitudinal axis of the vacuum cleaner that runs from a front end to a rear end thereof. It also includes an air inlet positioned forward of the pistol grip, and a vacuum motor configured to draw dirty air into a dirt separator of the vacuum cleaner through the air inlet and exhaust clean air from the vacuum cleaner through an air outlet. The handheld vacuum cleaner further includes an electronic visual display which faces generally rearwards. The handheld vacuum cleaner may be part of a stick vacuum cleaner.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: This application relates to methods and apparatus for temperature monitoring for integrated circuits, and in particular to temperature monitoring using a locked-loop circuits, e.g. FLLs, PLLs or DLLs. According to embodiments a locked-loop circuit (200, 600) includes a controlled signal timing module (201, 601), wherein the timing properties of an output signal (SOUT, SFB) are dependent on a value of a control signal and on temperature. A controller (201, 601) compares a feedback signal (SFB) output from the timing module to a reference signal (SREF) and generates a control signal (SC) to maintain a desired timing relationship. A temperature monitor (202) monitors temperature based on the value of the control signal. For FLLs and PLLs the signal timing module may be a controlled oscillator (201).

Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

Abstract: This application relates to computing circuitry (200, 500, 600) for analogue computing. A plurality of current generators (201) are each configured to generate a defined current (ID1, ID2, . . . IDj) based on a respective input data value (D1, D2, . . . Dj). A memory array (202), having at least one set (204) of programmable-resistance memory cells (203), is arranged to receive the defined currents from each of the current generators at a respective signal line (206). Each set (204) of programmable-resistance memory cells (203) includes a memory cell associated with each signal line that, in use, can be connected between the relevant signal line and a reference voltage so as to generate a voltage on the signal line. An adder module (207) is coupled to each of the signal lines to generate a voltage at an output node (210) based on the sum of the voltages on each of the signal lines.

Abstract: This application relates to methods and apparatus for temperature monitoring for integrated circuits, and in particular to temperature monitoring using a locked-loop circuits, e.g. FLLs, PLLs or DLLs. According to embodiments a locked-loop circuit (200, 600) includes a controlled signal timing module (201, 601), wherein the timing properties of an output signal (SOUT, SFB) are dependent on a value of a control signal and on temperature. A controller (201, 601) compares a feedback signal (SFB) output from the timing module to a reference signal (SREF) and generates a control signal (SC) to maintain a desired timing relationship. A temperature monitor (202) monitors temperature based on the value of the control signal. For FLLs and PLLs the signal timing module may be a controlled oscillator (201).